Novel vaccine strategy could solve the challenge of implanted device infections
Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but…
How nerve cells in the gut adapt to microbial and immune challenges
Ramnik Xavier, MD, PhD, of the Department of Molecular Biology at Massachusetts General Hospital, is the senior author…
Study reveals how melanoma evolves to resist immunotherapy
A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer,…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Scripps Research scientists receive NIH grant to unlock long-term HIV protection
Nearly 40 years after HIV was first identified, the virus continues its devastating march across the globe. Today,…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
TROP2 identified as a promising therapeutic target for renal medullary carcinoma
Researchers at The University of Texas MD Anderson Cancer Center, in collaboration with BostonGene, conducted the largest and…
Stem cells show promise in preventing post-heart attack heart failure
Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower…
The role of epigenetics in memory expression
Our experiences leave traces in the brain, stored in small groups of cells called “engrams”. Engrams are thought…
Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding
Researchers found that mothers who ate both peanuts and peanut butter during pregnancy had children with distinct DNA…
New insight into TRPM3 heat sensor reveals how the body detects temperature
The ability to sense heat protects the body from burns and injury. But how the body actually feels…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…