Key gene variants tied to developmental dysplasia of the hip and osteoarthritis
Developmental dysplasia of the hip (DDH) is a polygenetic disorder that increases the risk of hip osteoarthritis. A…
Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth
Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
Scientists map epigenetic changes across aging brain cells
Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer’s to Parkinson’s…
BCAT2 enzyme identified as a target for diabetic foot recovery
Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification…
How DNA and life experiences leave distinct marks on the human immune system
A high-resolution immune cell atlas reveals how inherited DNA and life-long environmental exposures leave separate epigenetic signatures that…
Epigenetic plasticity in germinal center B cells may help explain lymphoma origins
Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
ChronODE method offers precision in timing gene therapy treatments
A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on…
Polyphenols and exercise show promise in fighting gliomas
Scientists reveal how plant-based compounds and targeted workouts could work together to protect the brain, slow tumor progression,…
Scientists reveal how rare gene mutations drive schizophrenia risk
Uncovering how rare genetic changes disrupt brain signaling and structure, this landmark study sheds new light on the…
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy…