Early-life stress rewires brain epigenetics to heighten sensitivity to future stress
Mouse experiments reveal how early-life stress may leave a lasting epigenetic imprint in dopamine-related brain circuitry, priming molecular,…
LMU researchers reveal how different organs customize their internal clocks
LMU researchers have elucidated how different organs adapt the same clock machinery to regulate their individual needs over…
Obscure X chromosome protein emerges as key driver in several cancers
A little-known protein encoded on the X chromosome is attracting growing attention for its potential role in cancer…
Memory B cells reveal how nasal vaccines could stop respiratory infections earlier
New insights into lung-resident memory B cells show why the next generation of vaccines may need to protect…
Scientists say they may be closer than ever to reversing aging
In old age, the liver’s DNA packaging starts to come undone. That breakdown does not change the genetic…
Penn engineers use AI to solve some of science’s most difficult math problems
A ripple tells you something happened, but not exactly what. That is the core problem behind a hard…
Food timing may shape how T cells respond to infection and therapy
A new study reveals how lipids released after a meal can durably boost T cell metabolism, translation, and…
Key gene variants tied to developmental dysplasia of the hip and osteoarthritis
Developmental dysplasia of the hip (DDH) is a polygenetic disorder that increases the risk of hip osteoarthritis. A…
Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth
Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
Scientists map epigenetic changes across aging brain cells
Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer’s to Parkinson’s…
BCAT2 enzyme identified as a target for diabetic foot recovery
Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification…
How DNA and life experiences leave distinct marks on the human immune system
A high-resolution immune cell atlas reveals how inherited DNA and life-long environmental exposures leave separate epigenetic signatures that…