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Browsing Tag

Cytokine

8 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Study: Dietary iron deficiency impairs effector function of memory T cells following influenza infection. Image Credit: Corona Borealis Studio  / Shutterstock
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Poor dietary iron weakens lung memory T cells after flu infection

  • December 8, 2025
Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less…
HHealth
Study: Association of cesarean section with asthma and atopic dermatitis in infants from the Japan Environment and Children’s Study. Image Credit: Roman Fenton / Shutterstock
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Cesarean births do not raise infant allergy risk in major Japanese cohort study

  • November 14, 2025
A nationwide Japanese cohort finds no evidence that cesarean delivery increases early-life risks of eczema, wheezing, asthma, or…
HHealth
ACC Scientific Statement 29 September 2025 Share on Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology
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What clinicians and families can do now

  • September 30, 2025
A new ACC scientific statement shows that cholesterol control alone is not enough; targeting inflammation with lifestyle and…
HHealth
Study: Exploring the In Vitro Anti-Inflammatory Effect of Citrus Fruit Hesperidin Supplementation. Image Credit: kisa2014 / Shutterstock
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Citrus flavonoid hesperidin lowers oxidative damage in cell experiments

  • September 12, 2025
A citrus-derived flavonoid shows potent antioxidant and anti-inflammatory effects in immune cells, hinting at future therapeutic potential. Study:…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Scientists discover molecular brake that limits T cell attack on tumors

  • September 1, 2025
In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School…
HHealth
Study: Blueberry Consumption in Early Life and Its Effects on Allergy, Immune Biomarkers, and Their Association with the Gut Microbiome. Image Credit: SoNelly / Shutterstock 
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Babies fed blueberries show fewer allergy symptoms and boosted immune balance

  • September 1, 2025
Feeding blueberries to infants in the first year of life may help alleviate allergy symptoms and alter immune…
HHealth
Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis
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Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis

  • August 29, 2025
Common, treatable gut-related conditions signal Alzheimer’s and Parkinson’s disease risk long before symptoms, paving the way for earlier,…
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