Flipping a single DNA letter can trigger complete sex reversal
Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode…
Too many antioxidants may negatively affect future offspring
Antioxidants have been marketed as miracle supplements, touted for preventing chronic diseases and cancers; treating COPD and dementia;…
Real-time molecular recorders expose the inner lives of cells
Illustration: The Project Twins Cells are poor storytellers. They live complex, eventful lives — dividing, migrating, responding to…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
Spatial architecture of development and disease
Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …
Programmable Chromosome Engineering systems enable precise DNA manipulations
A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology…