New genetic screening method unlocks insights into human development
A new genetic screening method allows researchers to efficiently modulate individual genes across entire tissues and provides new…
Engineered scaffold restores skull growth in craniosynostosis mouse models
An engineered triphasic biomaterial scaffold successfully recreated the cranial suture stem cell niche lost in craniosynostosis, a condition…
Scientists Discover a Gene That Boosts Youth – but It Comes With a Cost
Researchers found that vgll3 boosts early-life growth and reproduction but increases aging and cancer risk later, providing strong…
Scientists Just Repeated a Nobel Prize-Winning Experiment in a Creature Older Than Jellyfish
Experiments on comb jelly embryos reveal that a core developmental process shared across animals may trace back to…
New AI tool predicts how cells choose their identity
A cell on its way to becoming skin pigment, blood, or nerve does not make that shift alone.…
Flipping a single DNA letter can trigger complete sex reversal
Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode…
Too many antioxidants may negatively affect future offspring
Antioxidants have been marketed as miracle supplements, touted for preventing chronic diseases and cancers; treating COPD and dementia;…
Real-time molecular recorders expose the inner lives of cells
Illustration: The Project Twins Cells are poor storytellers. They live complex, eventful lives — dividing, migrating, responding to…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
Spatial architecture of development and disease
Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …
Programmable Chromosome Engineering systems enable precise DNA manipulations
A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology…