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Browsing Tag

Fibrosis

11 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

  • December 9, 2025
Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments

  • December 5, 2025
A new multi-site study led by researchers at CU Anschutz shows that people with cystic fibrosis (CF) who…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Understanding leptin’s dual function in MAFLD pathogenesis

  • November 15, 2025
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with…
HHealth
Common dry cleaning chemical linked to liver disease
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Common dry cleaning chemical linked to liver disease

  • October 26, 2025
Liver disease is often linked to heavy drinking, obesity, or viral infections. But new research suggests another hidden…
GGenetics
New genetic discovery could change how Friedreich's ataxia is diagnosed
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New gene-editing method can correct many disease-causing mutations in mammalian cells

  • October 23, 2025
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Antihypertensive and lipid-lowering drugs show efficacy against steatotic liver disease

  • October 6, 2025
Metabolic dysfunction-associated steatotic liver disease is the most common liver disease in the world, affecting about one third…
HHealth
How mechanical changes in lung tissue trigger fibrosis
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How mechanical changes in lung tissue trigger fibrosis

  • September 6, 2025
Fibrosis of the lungs is often a silent disease until it’s too late. By the time patients are…
MMedication
Kiwi family move to Australia to get cystic fibrosis drug Trikafta for daughter
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Kiwi family move to Australia to get cystic fibrosis drug Trikafta for daughter

  • August 18, 2025
Adalyn Delaney was suffering the effects of CF before she was even born, with health staff discovering during…
HHealth
Study reveals how aging alters liver function and structure
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The vicious circle of aging and metabolic dysfunction-associated steatotic liver disease

  • August 1, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of…
HHealth
Review: The role of the gut microbiota and metabolites in heart failure and possible implications for treatment. Image Credit: Alexander_P / Shutterstock
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How a leaky gut could be putting your heart at risk

  • July 29, 2025
Emerging science reveals that an imbalanced gut may do more than upset your stomach; it could be fueling…
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