Blood gene signals reveal Parkinson’s risk years before diagnosis
Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of…
How DNA and life experiences leave distinct marks on the human immune system
A high-resolution immune cell atlas reveals how inherited DNA and life-long environmental exposures leave separate epigenetic signatures that…
Facial wound secrets revealed for scarless repair
Tweaking a pattern of wound healing established millions of years ago may enable scar-free injury repair after surgery…
Study reveals genetic signatures linked to HIV-related cognitive impairment
Using participant skin cells reprogrammed into neurons, Weill Cornell Medicine researchers have identified genetic signatures associated with HIV…
Restoring protein production in motor neuron axons
Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein…
Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering
All the cells in an organism have the exact same genetic sequence. What differs across cell types is…
Study uncovers role of mechanical forces in human gastrulation
Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding
Researchers found that mothers who ate both peanuts and peanut butter during pregnancy had children with distinct DNA…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
Forensic genetics in the omics era
Jeffreys, A. J., Wilson, V. & Thein, S. L. Individual-specific ‘fingerprints’ of human DNA. Nature 316, 76–79 (1985).…
Largest study of African American brain tissue reveals key Alzheimer gene activity
The prevalence of Alzheimer disease (AD) is approximately two times higher in African Americans (AA) compared to White/European-ancestry…