Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
Gut bacteria linked to how our genes switch on and off
Reading time: 2 minutesProfessor Alika Maunakea and research faculty Riley Wells The trillions of microbes that live in…
Is enhancer-driven gene regulation all wrapped up?
Symmons, O. et al. The Shh topological domain facilitates the action of remote enhancers by reducing the effects…
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity
BRG1 binding exhibits a linear response to its dosage In mES cells, Brg1 encodes the major catalytic subunit…
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases
Single-cell multiome dataset Single-cell multiome (snRNA-seq + snATAC-seq) data of the human left ventricle and lung were processed and clustered…