Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering
All the cells in an organism have the exact same genetic sequence. What differs across cell types is…
Study uncovers role of mechanical forces in human gastrulation
Only two weeks after fertilization, the first sign of the formation of the 3 axes of the human…
CRISPR-edited fungus boosts protein production and cuts environmental impact
In a new study publishing November 19 in the Cell Press journal Trends in Biotechnology, researchers used a…
Muscle-driven gene therapy shows promise for protecting memory in Alzheimer’s
Alzheimer’s disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment…
Subtle changes in the composition of short tandem repeats may shape disease risk
Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that…
Pig kidney transplant breakthrough uncovers immune rejection secrets
Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in…
Study clarifies how biliary atresia overlaps with multiple congenital syndromes
Biliary atresia (BA) represents one of the leading causes of pediatric liver failure, often requiring surgical intervention or…
Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes
Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in…
Study finds high intake of ultra-processed foods tied to reduced DNA methylation
Researchers have found that women who consume more ultra-processed foods exhibit widespread differences in DNA methylation, suggesting early…
Scientists uncover new obesity genes that reshape understanding of weight and disease risk
A global research team maps how rare and common gene variants jointly drive obesity and metabolic disease, offering…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
Reducing ketone levels and increasing exercise capacity could help manage diabetic ketoacidosis
A researcher at the University of Houston finds management of diabetic ketoacidosis may center around reducing ketone levels…