The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…
Type II mechanoreceptors and cuneate spiking neuronal network enable touch localization on a large-area e-skin
Sensitive FBG-based e-skin The experimented e-skin (Extended Data Fig. 5) had size and shape similar to those of…
Reconsidering space-for-time substitution in climate change ecology
Laboratory of Tree-Ring Research, University of Arizona, Tucson, AZ, USA Margaret E. K. Evans Department of Wildland Resources,…
Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries
Global Health Data Exchange (GHDx) (Institute of Health Metrics and Evaluation, accessed 1 November 2023); https://vizhub.healthdata.org/gbd-results Mental Health…
Contrasting biological production trends over land and ocean
Steffen, W. et al. The emergence and evolution of Earth System Science. Nat. Rev. Earth Environ. 1, 54–63…
Digital twins and Big AI: the future of truly individualised healthcare
Foundational Research Gaps and Future Directions for Digital Twins | National Academies. https://www.nationalacademies.org/our-work/foundational-research-gaps-and-future-directions-for-digital-twins. Coveney, P. V. & Highfield…
Predicting resistance to chemotherapy using chromosomal instability signatures
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
GeneAgent: self-verification language agent for gene-set analysis using domain databases
Model setting and data collection In this work, we utilized GPT-4 (version 20230613) as the backend model via…
Shifting hotspot of tropical cyclone clusters in a warming climate
Probabilistic TC cluster model To statistically analyse the climatology of TC clusters, we design a probabilistic TC cluster…
Rapid deployment of large language model DeepSeek in Chinese hospitals demands a regulatory response
Gibney, E. Nature 638, 13–14 (2025). CAS PubMed Google Scholar DeepSeek-AI et al. Preprint at http://arxiv.org/abs/2501.12948 (2025). Thirunavukarasu,…
Bridging psychiatry and rare genetic diseases: a scoping review of therapeutic strategies and diagnostic delay paired with healthcare economic burden analysis | Orphanet Journal of Rare Diseases
Nguengang Wakap S, Lambert DM, Olry A, Rodwell C, Gueydan C, Lanneau V, Murphy D, Le Cam Y,…