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Browsing Tag

Genes

123 posts
HHealth
Maldives achieves historic triple elimination of mother-to-child transmission of diseases
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Study reveals genetic signatures linked to HIV-related cognitive impairment

  • January 15, 2026
Using participant skin cells reprogrammed into neurons, Weill Cornell Medicine researchers have identified genetic signatures associated with HIV…
SScience
Ancient viral DNA found to regulate human gene expression
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Key protein in the tuberculosis bacterium helps protect itself from foreign DNA

  • January 10, 2026
Researchers at the Indian Institute of Science (IISc), with collaborators from the Institute of Mathematical Sciences (IMSc), have…
HHealth
Light-activated therapy boosts effectiveness of antifungal drugs against Candida albicans
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Plasmid-borne resistance drives global expansion of dangerous Klebsiella strains

  • December 31, 2025
A recent study published in Engineering has shed light on the transmission and epidemiological trends of tmexCD1-toprJ1-positive Klebsiella…
SScience
Griffith University launches groundbreaking treatment trial for spinal cord injury
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New computational method reconstructs how cells decide their fate

  • December 31, 2025
Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics…
HHealth
Excessive amounts of visceral fat tied to faster heart aging
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Imaging-enhanced knowledge graphs reveal new targets for heart disease treatment

  • December 31, 2025
Knowledge graphs are a powerful tool for bringing together information from biological databases and linking what is already known…
HHealth
Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy
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Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

  • December 13, 2025
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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AI uncovers how DNA architecture failures trigger blood cancer

  • December 11, 2025
Cancer isn’t just about broken genes-it’s about broken architecture. Imagine a city where roads suddenly vanish, cutting off…
TTechnology
Researchers unveil drug complex that makes cancer cells self-report to immune system
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A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

  • December 9, 2025
It’s not often that a pathologist gets to make a diagnosis that works for the patient by preventing…
HHealth
Study: Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro. Image Credit: Julien Tromeur / Shutterstock
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Industrial and farm chemicals quietly alter the balance of gut microbes

  • December 9, 2025
A large-scale laboratory screen reveals that widely used chemicals do more than contaminate food and water. They can…
HHealth
UCSF research maps over 600 conditions linked to endometriosis
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Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

  • December 5, 2025
A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common…
HHealth
3D illustration. DNA helix with damaged segment highlighted in red
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AI model popEVE: Prioritizing genetic variants effectively

  • December 3, 2025
By combining deep evolutionary signals with human population data, the popEVE model provides a novel approach to identifying…
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