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Browsing Tag

Inflammasome

5 posts
HHealth
A common dietary nutrient feeds a gut pathway linked to atrial fibrillation
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A common dietary nutrient feeds a gut pathway linked to atrial fibrillation

  • July 28, 2026
A 5,090-person cohort and complementary mouse experiments trace how a diet-linked microbial pathway could reshape atrial structure, electrical…
TTechnology
Study: Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP. Image Credit: pimpampix / Shutterstock
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Statins may trigger muscle side effects by activating inflammatory danger signals

  • June 23, 2026
New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
SScience
New EASD guideline combines clinical standards with lived experience
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Metformin protects neurons after brain injury by restoring mitochondrial health

  • April 13, 2026
TBI remains a major cause of death and long-term neurological disability worldwide, yet effective treatments for secondary injury…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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New NIH grants fuel research in oral cancer treatment and pain relief

  • November 8, 2025
Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University…
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