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Browsing Tag

Ion

8 posts
SScience
Scientists identify a molecular switch that controls water flow in the gut
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Scientists identify a molecular switch that controls water flow in the gut

  • January 10, 2026
Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how…
HHealth
SN101 iPSC-derived therapy relieves chronic pain and preserves joints
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SN101 iPSC-derived therapy relieves chronic pain and preserves joints

  • December 13, 2025
SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New technique revolutionizes the design of drugs that target ion channels
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New technique revolutionizes the design of drugs that target ion channels

  • November 14, 2025
An international team involving the Institute of Chemical Research, a joint centre of the University of Seville and…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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New NIH grants fuel research in oral cancer treatment and pain relief

  • November 8, 2025
Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University…
HHealth
Researchers unveil drug complex that makes cancer cells self-report to immune system
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Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects

  • November 5, 2025
Recently, a team led by Academician Hongjie Zhang, Researcher Shuyan Song, Associate Researcher Pengpeng Lei, and Dr. Ran An…
HHealth
Study: SLC45A4 is a pain gene encoding a neuronal polyamine transporter. Image Credit: Gorodenkoff / Shutterstock
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How a single gene reshapes pain perception through polyamine signaling

  • August 25, 2025
A breakthrough discovery reveals how the SLC45A4 gene fine-tunes polyamine transport in sensory neurons, reshaping our understanding of…
HHealth
New method enables comprehensive analysis of metabolites in biological samples
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New method enables comprehensive analysis of metabolites in biological samples

  • August 22, 2025
Researchers from the McCullagh Group in Oxford University’s Department of Chemistry have published an innovative method in Nature…
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