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Browsing Tag

Ion

14 posts
HHealth
Study identifies Piezo channels as targets for orthodontic care
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Study identifies Piezo channels as targets for orthodontic care

  • October 12, 2026
A new review in Genes & Diseases highlights Piezo channels as important biological links between mechanical forces and…
HHealth
Scorpion venom peptides: Novel therapeutic approaches for inflammatory and hepatic disorders
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Could scorpion venom inspire new treatments for liver disease?

  • September 8, 2026
From blocking inflammatory immune pathways to disrupting hepatitis viruses, scorpion-derived peptides are attracting attention as potential drug candidates,…
TTV
TGL's women's league secures media rights deal with ESPN, ION
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TGL’s women’s league secures media rights deal with ESPN, ION

  • September 2, 2026
TMRW Sports’ WTGL, the women’s version of TGL set to launch this winter, has secured its first media…
AAustralia
ION secures first global partners, advancing Australia's next generation of life sciences innovation
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ION secures first global partners, advancing Australia’s next generation of life sciences innovation

  • May 25, 2026
Sydney’s life sciences sector has reached a major milestone, with Kurraba Group announcing the first confirmed partners for…
SScience
Understanding PIEZO2 mutations and sensory disorders
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Understanding PIEZO2 mutations and sensory disorders

  • March 9, 2026
Every time we feel a gentle tap on the skin, specialized nerve cells convert that physical force into…
AAustralia
Sayer Stunner! Fowler Ends Goal Drought & Kennedy Brace | Matildas 4-0 Iran Highlights
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Sayer Stunner! Fowler Ends Goal Drought & Kennedy Brace | Matildas 4-0 Iran Highlights

  • March 5, 2026
Sayer Stunner! Fowler Ends Goal Drought & Kennedy Brace | Matildas 4-0 Iran Highlights | Matildas Select category…
SScience
Scientists identify a molecular switch that controls water flow in the gut
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Scientists identify a molecular switch that controls water flow in the gut

  • January 10, 2026
Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how…
HHealth
SN101 iPSC-derived therapy relieves chronic pain and preserves joints
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SN101 iPSC-derived therapy relieves chronic pain and preserves joints

  • December 13, 2025
SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New technique revolutionizes the design of drugs that target ion channels
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New technique revolutionizes the design of drugs that target ion channels

  • November 14, 2025
An international team involving the Institute of Chemical Research, a joint centre of the University of Seville and…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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New NIH grants fuel research in oral cancer treatment and pain relief

  • November 8, 2025
Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University…
HHealth
Researchers unveil drug complex that makes cancer cells self-report to immune system
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Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects

  • November 5, 2025
Recently, a team led by Academician Hongjie Zhang, Researcher Shuyan Song, Associate Researcher Pengpeng Lei, and Dr. Ran An…
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