Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex
Fijarczyk, A. & Babik, W. Detecting balancing selection in genomes: limits and prospects. Mol. Ecol. 24, 3529–3545 (2015).…
US drug pricing shake-up threatens access to medicines in Europe – POLITICO
For European drugmakers there are still many unknowns about how the MFN scheme — and overall tariffs on…
Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory
Neural organoids were differentiated from iPSC-derived Neural Progenitor Cells (NPC) for up to 14 weeks and characterized throughout development…
Isotope analysis of fossil teeth provides insight into the habitat and life histories of the early hominin Paranthropus robustus
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Morphological map of under- and overexpression of genes in human cells
Mattiazzi Usaj, M. et al. High-content screening for quantitative cell biology. Trends Cell Biol. 26, 598–611 (2016). CAS …
Archived natural DNA samplers reveal four decades of biodiversity change across the tree of life
Specimen bank data This research complies with all relevant ethical regulations. All study protocols are approved by the…
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…
Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries
Global Health Data Exchange (GHDx) (Institute of Health Metrics and Evaluation, accessed 1 November 2023); https://vizhub.healthdata.org/gbd-results Mental Health…
GeneAgent: self-verification language agent for gene-set analysis using domain databases
Model setting and data collection In this work, we utilized GPT-4 (version 20230613) as the backend model via…
Recognify’s Phase IIb trial of schizophrenia therapy fails to meet primary goal
atai Life Sciences (ATAI) company Recognify Life Sciences has reported that its Phase IIb trial of oral compound,…