lipid - Australia News Beep

A comparative study to evaluate the identification of lipids using untargeted lipidomics analysis. Lipid extracts were prepared from NIST SRM 1950 human plasma, and a 0.5 µl plasma equivalent was analyzed on the ZenoTOF 7600 or 8600 system using CID-based fragmentation. A reversed-phase chromatographic strategy was used to resolve lipids, and they were analyzed in the positive ionization mode. Data were processed using MS-DIAL 5.5 software to identify reference-matched lipids. Data acquired on the ZenoTOF 8600 system enabled the identification of ~1.8-fold more lipids than the ZenoTOF 7600 system with CID-based fragmentation and ~2.4-fold more with EAD-based fragmentation

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Advancing lipid identification in human plasma samples

July 18, 2025

In this article, data-dependent acquisition (DDA) experimental data collected by the ZenoTOF 8600 system was analyzed with MS-DIAL…