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Browsing Tag

Liver

50 posts
HHealth
Shared gene signatures reveal metabolic dysfunction in liver cirrhosis and acute-on-chronic liver failure
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Blocking platelet-activating factor reduces liver damage in cirrhosis

  • December 20, 2025
Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Study: The relationship between serum total alkaline phosphatase and risk of osteoporosis: a cross-sectional study. Image Credit: Javier Regueiro / Shutterstock
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Routine blood test may flag hidden osteoporosis risk, study finds

  • December 9, 2025
Common blood test results may offer an early clue to bone loss, suggesting that alkaline phosphatase levels could…
HHealth
Study: Dietary iron deficiency impairs effector function of memory T cells following influenza infection. Image Credit: Corona Borealis Studio  / Shutterstock
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Poor dietary iron weakens lung memory T cells after flu infection

  • December 8, 2025
Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less…
HHealth
Calcium supplements do not prevent pre-eclampsia, large trials show no meaningful benefit
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Calcium supplements do not prevent pre-eclampsia, large trials show no meaningful benefit

  • December 8, 2025
A new Cochrane systematic review of 10 randomised trials involving over 37,000 pregnant women found that calcium supplementation…
HHealthcare
NewLimit 'close' to clinic-ready epigenetic reprogramming therapy
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NewLimit ‘close’ to clinic-ready epigenetic reprogramming therapy

  • November 29, 2025
Liver rejuvenation program produces a ‘lead payload’ as biotech begins its journey towards human clinical trials. After several…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Understanding leptin’s dual function in MAFLD pathogenesis

  • November 15, 2025
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Study clarifies how biliary atresia overlaps with multiple congenital syndromes

  • November 12, 2025
Biliary atresia (BA) represents one of the leading causes of pediatric liver failure, often requiring surgical intervention or…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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How artificial light interferes with liver health

  • November 4, 2025
People who work against their internal clock over a long period of time increase the risk of fatty…
HHealth
Study: A market and risk assessment of 125 turmeric supplements available in Australia, Germany, India, UK, and USA. Image Credit: shinshila / Shutterstock
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Inconsistent labels and risky doses found in turmeric supplements worldwide

  • November 4, 2025
An new study reveals major gaps in the regulation and transparency of turmeric supplements, highlighting how weak oversight…
HHealth
Genetically-engineered immune cells show promise for preventing organ rejection
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Reducing ketone levels and increasing exercise capacity could help manage diabetic ketoacidosis

  • October 30, 2025
A researcher at the University of Houston finds management of diabetic ketoacidosis may center around reducing ketone levels…
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