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Browsing Tag

Lungs

22 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

  • December 9, 2025
Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve…
HHealth
Study: Dietary iron deficiency impairs effector function of memory T cells following influenza infection. Image Credit: Corona Borealis Studio  / Shutterstock
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Poor dietary iron weakens lung memory T cells after flu infection

  • December 8, 2025
Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less…
HHealth
Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments
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Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments

  • December 5, 2025
A new multi-site study led by researchers at CU Anschutz shows that people with cystic fibrosis (CF) who…
HHealth
Efficacy of methylprednisolone doses in severe Mycoplasma Pneumonia
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Bacterial enzyme linked to heart complications in pneumonia

  • December 5, 2025
Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each…
HHealth
Long-term exposure to polluted air weakens the health benefits of exercise
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Long-term exposure to polluted air weakens the health benefits of exercise

  • November 29, 2025
Long-term exposure to toxic air can substantially weaken the health benefits of regular exercise, suggests a new study…
HHealth
Wild birds found to be key drivers of H5N1 outbreak in North America
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Fever-resistant bird flu viruses pose a significant threat to humans

  • November 29, 2025
Bird flu viruses are a particular threat to humans because they can replicate at temperatures higher than a…
HHealth
Doctor tripped up by $64K bill for ankle surgery and hospital stay
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Lung to gut movement of hospital-acquired bacterium raises the risk of sepsis

  • November 25, 2025
A hospital-acquired bacterium that causes serious infections can move from the lungs to the gut inside the same…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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What the air you breathe may be doing to your brain

  • November 12, 2025
For years, the two patients had come to the Penn Memory Center at the University of Pennsylvania, where…
HHealth
Simple UV technology reduces the number of respiratory infections in aged care facilities
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Groundbreaking vaccination approach could transform respiratory disease prevention

  • November 10, 2025
A research team from Trinity College Dublin has unveiled a groundbreaking new approach to vaccination that could redefine how…
HHealth
Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors
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Improving diagnosis, treatment and follow-up care for pulmonary embolism

  • October 31, 2025
Pulmonary embolism (PE), a type of blood clot in the lungs, sends more than half a million people…
HHealth
Research: Prenatal Exposure to Fine Particulate Matter Components and Autism Risk in Childhood. Image Credit: chayanuphol / Shutterstock
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Prenatal air pollution exposure tied to higher autism risk in children

  • October 26, 2025
New findings from Ontario’s largest birth cohort reveal that sulfate and ammonium particles in fine air pollution may…
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