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Browsing Tag

Metabolism

100 posts
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Reframing the role of MCL1 in cancer signaling and metabolism

  • December 23, 2025
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
SScience
Brighter Side of News
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Living plants and animals emit a faint glow that fades after death

  • December 21, 2025
Living organisms quietly emit light. This glow is real, measurable, and tied to life itself. Researchers at the…
NNutrition
Study: Vitamin B12: A Comprehensive Review of Natural vs Synthetic Forms of Consumption and Supplementation. Image Credit: Fida Olga / Shutterstock
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Why the form of vitamin B12 you take may matter more than your intake

  • December 12, 2025
A new scientific review weighs natural and synthetic forms of vitamin B12, revealing where methylcobalamin may outperform standard…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
SScience
Study: Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency. Image Credit: Julien Tromeur / Shutterstock
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Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

  • December 10, 2025
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
HHealth
Epigenetic editing enables safer and more effective T cell therapies
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Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

  • November 29, 2025
Researchers from the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology…
HHealth
How the gut microbiome links obesity to colorectal cancer
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How the gut microbiome links obesity to colorectal cancer

  • November 28, 2025
Study: From obesity to cancer: Gut microbiome mechanisms, biomarkers, and U.S. public health strategies. Image Credit: Shutterstock AI…
HHealth
Neurocognitive and Neurological Effects of Coffee and Caffeine: A Narrative Review. Image Credit: Igor_83 / Shutterstock
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Does coffee truly boost memory and focus or is it all hype?

  • November 24, 2025
A new narrative review unpacks how coffee may sharpen thinking and protect the brain while highlighting why its…
HHealth
Study: Efficacy and safety of glucagon-like peptide 1 receptor agonists across all health outcomes in type 2 diabetes: An umbrella review and evidence map of randomised controlled trials. Image Credit: zimmytws / Shutterstock
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Study compares GLP-1 drug benefits and finds substantial variation in clinical effects

  • November 20, 2025
A new umbrella review reveals how GLP-1 therapies shape cardiovascular, renal, and metabolic outcomes in type 2 diabetes…
FFitness
Scientists discover molecule that acts like exercise and slows signs of ageing
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Scientists discover molecule that acts like exercise and slows signs of ageing

  • November 17, 2025
For years, scientists have tried to unpack why regular exercise keeps the body young while a single tough…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Understanding leptin’s dual function in MAFLD pathogenesis

  • November 15, 2025
Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Researchers achieve long-term remission with novel T cell therapies for HPV-related cancers

  • November 11, 2025
Researchers from Rutgers Cancer Institute, New Jersey’s only National Cancer Institute (NCI) – designated Comprehensive Cancer Center, and…
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