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Browsing Tag

metformin

8 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealthcare
Yahoo news home
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Scientists Just Discovered a Surprising Side Effect of a Popular Diabetes Drug

  • November 23, 2025
Reviewed by Dietitian Emily Lachtrupp, M.S., RD Getty Images. EatingWell Design. Key Points Metformin may blunt blood vessel…
MMedication
Metformin
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Metformin, Meaning, Uses, Latest News

  • November 14, 2025
Metformin is an anti-diabetic medication (biguanide). Read more about Metformin, Meaning, Uses, Latest News. Metformin Latest News Metformin…
FFitness
Yahoo news home
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Scientists warn common diabetes drug may be cancelling out benefits of exercise

  • November 8, 2025
A widely prescribed diabetes drug may be blunting the beneficial effects of exercise in patients, a new study…
HHealth
New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy
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Diabetes drug blunts exercise-induced health improvements

  • November 7, 2025
A widely prescribed diabetes drug may be sabotaging one of the most trusted strategies for preventing the disease:…
HHealth
Study: Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function. Image Credit: Juan Gaertner / Shutterstock
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Why metformin could protect the brain by rewiring mitochondria

  • September 2, 2025
A new study shows metformin enhances myelin repair in human-based models by tuning mitochondrial metabolism, offering hope for…
HHealth
Study: Low-dose metformin requires brain Rap1 for its antidiabetic action. Image Credit: Kateryna Kon / Shutterstock
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Metformin’s blood sugar control starts in the brain, not just the liver, study finds

  • August 4, 2025
Scientists uncover how low-dose metformin targets brain pathways to lower blood sugar, opening fresh avenues for safer and…
MMedication
Are GLP-1s or metformin linked to lower dementia risk?
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Are GLP-1s or metformin linked to lower dementia risk?

  • July 29, 2025
Share on PinterestGLP-1 agonists vs metformin: Which diabetes drugs are linked to the lowest dementia risk? Image credit:…
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