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Browsing Tag

Microglia

8 posts
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Immune cells found to actively promote plaque formation in Alzheimer’s disease

  • March 10, 2026
A new study led by researchers from VIB and KU Leuven shows that immune cells called microglia can…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Grant supports research into how microglia may spread toxic tau in Alzheimer’s

  • February 21, 2026
A researcher with the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio has…
HHealth
Brain immune cells drive persistent negative emotions after repeated binge drinking
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Brain immune cells drive persistent negative emotions after repeated binge drinking

  • January 13, 2026
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Disruption of glial circadian rhythms linked to Alzheimer’s disease progression

  • October 23, 2025
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
HHealth
Senior woman by the window smelling yellow daffodil,
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Smell loss emerges as the early behavioural sign of Alzheimer’s

  • September 4, 2025
New research reveals that immune cells attack brainstem nerve fibers linked to smell, making loss of smell the…
HHealth
Participants in the Northwestern University SuperAging study gathered on May 24, 2013, to mingle and socialize. Photograph by Ben Kesling, at the time with The Wall Street Journal. Study: The first 25 years of the Northwestern University SuperAging Program
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Special von Economo neurons may hold key to super-sharp memory in 80+ superagers

  • August 11, 2025
A 25-year study of ‘superagers’ reveals the brain and lifestyle factors that help some older adults defy typical…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Targeted microglia replacement shows promise against fatal neurodegenerative conditions

  • August 6, 2025
Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within…
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