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Browsing Tag

oxygen

22 posts
SScience
Example photographs of primary, mixed, and secondary halite inclusion assemblages. Image credit: Park et al., doi: 10.1073/pnas.2513030122.
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Scientists Find Ancient Air Bubbles in 1.4 Billion-Year-Old Salt Crystals

  • December 23, 2025
Researchers have found ancient gases and fluids trapped in 1.4-billion-year-old halite crystals from northern Ontario, Canada. Their analyses…
SScience
Study: Acute Impact of Polyphenol-Rich vs. Carbohydrate-Rich Foods and Beverages on Exercise-Induced ROS and FRAP in Healthy Sedentary Female Adults - A Randomized Controlled Trial. Image Credit: Improvisor / Shutterstock
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How specific foods reshape oxidative stress responses during and after high-intensity training

  • December 12, 2025
A new randomized trial reveals how simple food choices before and after fasted HIIT can shift the body’s…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
SScience
Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction
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Collaborative project seeks safer therapies for ischemia and reperfusion injury

  • December 11, 2025
Southwest Research Institute (SwRI) and Trinity University will improve a prodrug, a compound activated in the body, to…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Tiny metal particles can kill cancer cells while leaving healthy cells unharmed

  • December 2, 2025
An international research team led by RMIT University have created tiny particles, known as nanodots, made from a…
SScience
Innate immunity and metabolic stress drive a unique form of cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
HHealth
Earlier blood transfusion reduces heart complications post-surgery in high-risk patients
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Earlier blood transfusion reduces heart complications post-surgery in high-risk patients

  • November 11, 2025
An earlier blood transfusion- done when hemoglobin levels were higher – after major general or vascular surgery among…
TTechnology
Image Credit: FOTOGRIN/Shutterstock.com
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Redefining control in anaerobic microbiome workflows

  • November 5, 2025
In this interview, Sheela Muley, Product Manager at Molecular Devices, and Dr Sushmita Sudarshan, Application Scientist in Assay Development at Molecular Devices,…
HHealth
Old chemistry unlocks safer and stronger mRNA delivery
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Free radicals generated at a specific site in astrocytes may promote dementia

  • November 4, 2025
Researchers have discovered that free radicals generated at a specific site in non-neuronal brain cells called astrocytes, may…
HHealth
Babies living with dogs show better lung function and reduced asthma rates
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Research opens new avenues for treating asthma and other inflammatory diseases

  • October 23, 2025
For decades, scientists have thought they understood the biochemical machinery that causes asthma-inflammation in the lungs that constricts…
HHealth
Study: Dietary Strawberries Improve Serum Antioxidant Profiles in Adults with Prediabetes: A 28-Week Randomized Controlled Crossover Trial. Image Credit: Vidic Bojan / Shutterstock
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Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

  • October 22, 2025
Researchers found that daily freeze-dried strawberry intake enhanced antioxidant biomarkers, lowered inflammation, and improved fasting glucose, suggesting a…
SScience
A dangerous glitch in the carbon cycle could freeze Earth over
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A dangerous glitch in the carbon cycle could freeze Earth over

  • September 27, 2025
In the grand theater of planetary climate, Earth has always played a balancing act, teetering between fire and…
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