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Browsing Tag

pH

42 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Uncovering the secrets of ‘SuperAgers’ and cognitive longevity
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Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

  • December 12, 2025
Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name –…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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AI uncovers how DNA architecture failures trigger blood cancer

  • December 11, 2025
Cancer isn’t just about broken genes-it’s about broken architecture. Imagine a city where roads suddenly vanish, cutting off…
HHealth
Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative
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Van Andel Institute and Cure Parkinson’s extend major Parkinson’s drug trial initiative

  • December 10, 2025
Van Andel Institute and Cure Parkinson’s have renewed a funding agreement to support the International Linked Clinical Trials…
TTechnology
Researchers unveil drug complex that makes cancer cells self-report to immune system
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A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

  • December 9, 2025
It’s not often that a pathologist gets to make a diagnosis that works for the patient by preventing…
HHealth
New expert recommendations redefine exercise as therapy for children with asthma
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Muscle-driven gene therapy shows promise for protecting memory in Alzheimer’s

  • November 18, 2025
Alzheimer’s disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment…
HHealth
Study identifies a promising new strategy for treating alcohol use disorder
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Exploring endogenous retroviruses as hidden drivers of alcohol use disorder

  • November 8, 2025
Alcohol use disorder (AUD), characterized by uncontrollable alcohol consumption due to physical and psychological dependence, affects approximately 14.1…
HHealth
Novel vaccine strategy could solve the challenge of implanted device infections
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Novel vaccine strategy could solve the challenge of implanted device infections

  • November 4, 2025
Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but…
HHealth
Long COVID linked to lasting financial hardship and work disruption
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New BRIGHT Center aims to build resilience after trauma

  • October 24, 2025
The Medical University of South Carolina has been awarded more than $11 million by the National Institute of…
HHealth
PSMA PET/CT improves outcomes for men with recurrent prostate cancer
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Breakthrough combo therapy lowers death risk in recurrent prostate cancer

  • October 24, 2025
Men whose prostate cancer returns after surgery or radiation therapy may now benefit from a new drug combination…
GGolf
Tambalque, Saga lead PH golf squad in Asian Youth Games
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Tambalque, Saga lead PH golf squad in Asian Youth Games

  • October 22, 2025
MANILA, Philippines — Top young Filipino shotmakers begin their bid in the 2025 Asian Youth Games golf competition…
HHealth
OU researchers explore how cannabis use affects recovery after head and neck cancer surgery
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Targeting bacterial communication may offer antibiotic-free wound therapy

  • October 15, 2025
Researchers at University of California San Diego School of Medicine have discovered a previously unrecognized mechanism by which…
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