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Browsing Tag

pH

49 posts
TTechnology
Insights into the clinical presentation and management of sellar chondrosarcomas
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Smartwatch data may help detect opioid misuse risk

  • February 6, 2026
Opioid overdoses continue to take a devastating toll across the United States. According to the U.S. Centers for…
HHealth
PSMA PET/CT improves outcomes for men with recurrent prostate cancer
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New trial tests strategies to protect heart health during prostate cancer therapy

  • January 27, 2026
City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States…
HHealth
Cats with dementia show brain changes similar to Alzheimer’s in humans
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Genetic study establishes causal link between obesity and cognitive decline

  • January 23, 2026
People with obesity and high blood pressure may face a higher risk of dementia, according to a new study published in The Journal of Clinical…
HHealth
First comprehensive road map shows how the ovarian reserve forms in primates
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Targeted uterine mRNA treatment boosts fertility outcomes in mice

  • January 23, 2026
Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine – which designs nanotechnology-based platforms for…
SScience
Griffith University launches groundbreaking treatment trial for spinal cord injury
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Stimulating immune cells could offer new treatment for nerve injury pain

  • January 8, 2026
Researchers at The University of Texas MD Anderson Cancer Center have discovered that targeting a specific immune process…
HHealth
New insights reveal persistent genome structure during cell division
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New insights into the global expansion of Candida auris

  • December 31, 2025
The fungal species Candida auris is spreading across the globe, and gaining in virulence, according to a new…
SScience
Middle precentral gyrus plays key role in orchestrating speech movements
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Engineered sensor reveals the brain’s hidden chemical conversations

  • December 24, 2025
Scientists have engineered a protein able to record the incoming chemical signals of brain cells (as opposed to…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Uncovering the secrets of ‘SuperAgers’ and cognitive longevity
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Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

  • December 12, 2025
Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name –…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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AI uncovers how DNA architecture failures trigger blood cancer

  • December 11, 2025
Cancer isn’t just about broken genes-it’s about broken architecture. Imagine a city where roads suddenly vanish, cutting off…
HHealth
Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative
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Van Andel Institute and Cure Parkinson’s extend major Parkinson’s drug trial initiative

  • December 10, 2025
Van Andel Institute and Cure Parkinson’s have renewed a funding agreement to support the International Linked Clinical Trials…
TTechnology
Researchers unveil drug complex that makes cancer cells self-report to immune system
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A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

  • December 9, 2025
It’s not often that a pathologist gets to make a diagnosis that works for the patient by preventing…
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