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Browsing Tag

Preclinical

15 posts
HHealth
SN101 iPSC-derived therapy relieves chronic pain and preserves joints
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SN101 iPSC-derived therapy relieves chronic pain and preserves joints

  • December 13, 2025
SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach…
HHealth
New computer program mimics cell behavior for faster medical discoveries
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UC Irvine receives funding for clinical trial of neural stem cell therapy for Huntington’s disease

  • December 13, 2025
Leslie M. Thompson, Donald Bren Professor of psychiatry and human behavior as well as neurobiology and behavior at…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
The feet of an elderly woman walking on the sidewalk
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5,000 steps a day may slow Alzheimer’s-related brain changes

  • November 6, 2025
New research reveals that even modest daily walking can slow the buildup of Alzheimer’s-linked proteins and delay cognitive…
HHealth
Intelligent learning can accelerate global efforts to prevent cervical cancer
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Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

  • November 1, 2025
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
SScience
Balancing copper antimicrobials to combat antibiotic resistance
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Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

  • October 30, 2025
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
HHealth
Agricultural dust exposure may pose significant risks to gut health
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Discovery of vascular-associated fibroblastic cells opens new path for diabetes treatment

  • October 9, 2025
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the cells that produce…
GGenetics
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Genetic modification enhances “living drugs” for blood cancers

  • September 25, 2025
CAR T cells are patient-derived, genetically engineered immune cells. They are “living drugs” and constitute a milestone in…
HHealth
Fresh carrots bunch on a grey stone background
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Carrot fiber supplement boosts gut bacteria and immune defenses

  • September 18, 2025
In just four weeks, a daily 500 mg dose of carrot-derived fiber enriched beneficial Bifidobacteria, firmed stools, and…
GGenetics
Study: Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study. Image Credit: Voyagerix / Shutterstock
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Genetic study shows dual GIPR/GLP1R action curbs binge alcohol use

  • September 15, 2025
New genetic evidence suggests that targeting GIPR and GLP1R could reduce harmful drinking patterns while improving liver and…
HHealth
Microplastics and nanoplastics: tiny threats for cardiovascular diseases? Image Credit: Shutterstock
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Experts warn tiny plastics in arteries may raise heart attack risk

  • September 11, 2025
Experts reveal how plastic particles lodged in arteries could heighten heart disease risk, demanding urgent attention from clinicians…
HHealth
Mediterranean-style diet benefits maternal health during pregnancy and breastfeeding
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Mediterranean-style diet benefits maternal health during pregnancy and breastfeeding

  • September 10, 2025
A Mediterranean-style diet, rich in fiber, vegetable proteins and healthy fats, benefits maternal health during pregnancy and breastfeeding.…
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