Spatial architecture of development and disease
Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …
Imaging-based multimodal profiling of single cells with STAMP
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced our ability to dissect complex biological systems at cellular resolution. However,…
Stem-like peripheral helper T cells found to sustain inflammation in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on…
Alzheimer’s research reaches a critical tipping point
One-third of people older than 85 in the United States are estimated to live with Alzheimer’s disease today,…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…
Precisely defining disease variant effects in CRISPR-edited single cells
Cell-line cultures and genomic editing HH cutaneous T cell lines (ATCC, CRL-2105), Jurkat E6-1 (ATCC, TIB-152) and Daudi…