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Browsing Tag

Transplant

29 posts
HHealth
Targeting lactate metabolism offers new avenues for cancer treatment
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New method identifies key proteins that trigger harmful immune responses

  • April 6, 2026
Mayo Clinic researchers have developed a new method to identify which proteins are most likely to trigger an…
EEnvironment
Hand-raised baby corals bring hope of restoring Great Barrier Reef
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Hand-raised baby corals bring hope of restoring Great Barrier Reef

  • March 29, 2026
Tens of thousands of baby coral, grown on land or settled from wild spawn slicks, have been transplanted…
HHealth
Child holding decorative model intestine.
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New microbiome therapy improves autism symptoms in children

  • March 18, 2026
A novel gut microbiome therapy delivers broad symptom improvements in children with autism, offering early hope for a…
HHealth
Childhood cancer survivor vowing to live 'life to the fullest' after heart transplant
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Childhood cancer survivor vowing to live ‘life to the fullest’ after heart transplant

  • March 1, 2026
Chemotherapy helped save Sienna Howkins’s life as a four-year-old, but it damaged her heart so much, she needed…
HHealth
Light-activated therapy boosts effectiveness of antifungal drugs against Candida albicans
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Engineered Listeria boosts innate immunity against cancer

  • February 14, 2026
After nearly 40 years of research on how Listeria bacteria manipulate our cells and battle our immune system…
HHealth
Lungs and trachea.
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Artificial lung keeps patient alive after lung removal

  • February 5, 2026
By replacing both breathing and circulatory buffering, a novel artificial lung bought critical time after lung removal, revealed…
HHealthcare
Spain achieves the world's first face transplant with a donor who was euthanised
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Spain achieves the world’s first face transplant with a donor who was euthanised

  • February 3, 2026
A hospital in Spain has achieved a significant medical breakthrough by performing the world’s first face transplant using…
HHealth
'Thriving' three year old facing second life-changing transplant
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‘Thriving’ three year old facing second life-changing transplant

  • January 18, 2026
Etta Cartmill has spent much of her young life in hospital, fighting to survive. The toddler and her…
HHealth
Innovative projects funded to improve health outcomes
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Innovative projects funded to improve health outcomes

  • January 14, 2026
Research to improve outcomes for transplant patients, identify osteoporosis risk, protect and strengthen bones and prevent the spread…
HHealth
Australian medical history – the heart donor who still walks the earth 20 years later
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Australian medical history – the heart donor who still walks the earth 20 years later

  • December 26, 2025
It sounds like a fairy tale. A beautiful young woman gives her heart away and goes on to…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New computer program mimics cell behavior for faster medical discoveries
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Young donor age proves critical for survival after stem cell transplantation

  • November 21, 2025
The selection of suitable donors is crucial for the long-term recovery of patients after an allogeneic hematopoietic stem…
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