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Browsing Tag

Transplant

19 posts
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
New computer program mimics cell behavior for faster medical discoveries
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Young donor age proves critical for survival after stem cell transplantation

  • November 21, 2025
The selection of suitable donors is crucial for the long-term recovery of patients after an allogeneic hematopoietic stem…
HHealthcare
Yahoo news home
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Scientists discover why pig kidneys were being rejected by transplant patients

  • November 15, 2025
Transplanting gene-edited pig kidneys into humans has been hailed as a pioneering procedure and a way to help…
HHealth
Epigenetic editing enables safer and more effective T cell therapies
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Pig kidney transplant breakthrough uncovers immune rejection secrets

  • November 13, 2025
Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in…
HHealth
New approach to kidney transplant listing could improve outcomes and equity
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New approach to kidney transplant listing could improve outcomes and equity

  • November 13, 2025
The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration…
HHealth
Corneas from diabetic donors perform well in vision restoring surgeries
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Corneas from diabetic donors perform well in vision restoring surgeries

  • October 21, 2025
Many eye banks won’t accept corneas from donors with diabetes, concerned they might be harder to prepare for…
HHealth
Breakthrough gene therapy reverses genetic deafness across age groups
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Experimental gene therapy restores immune system function in children with genetic immune disorder

  • October 16, 2025
An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored…
WWildlife
Emergency Butterfly Wing Transplant Is a Success Watched by Millions on Social Media
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Emergency Butterfly Wing Transplant Is a Success Watched by Millions on Social Media

  • October 10, 2025
  Sweetbriar Nature Center – via Storyful With a pioneering procedure, a nature center in New York made…
GGenetics
Newborn genomic screening may detect hundreds of additional childhood conditions
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Newborn genomic screening may detect hundreds of additional childhood conditions

  • October 9, 2025
Adding genomic sequencing to newborn blood screening would detect hundreds of additional childhood conditions, providing much earlier diagnosis…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Study reports the world’s first genetically engineered pig-to-human liver xenotransplantation

  • October 9, 2025
An important new study in the Journal of Hepatology, published by Elsevier, reports the world’s first auxiliary liver…
HHealth
Scientists convert type A kidney to type O for first human transplant
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Scientists convert type A kidney to type O for first human transplant

  • October 4, 2025
For those with kidney failure, a transplant is often the greatest promise of a healthier, longer life. Yet…
HHealth
Early treatment withdrawal offers safety and savings for patients with rare kidney disease
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Breakthrough in building functional synthetic kidneys using assembloids

  • September 17, 2025
A USC Stem Cell-led research team has achieved a major step forward in the effort to build mouse…
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