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Browsing Tag

Vascular

25 posts
HHealth
Shared gene signatures reveal metabolic dysfunction in liver cirrhosis and acute-on-chronic liver failure
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Blocking platelet-activating factor reduces liver damage in cirrhosis

  • December 20, 2025
Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural…
HHealth
Cats with dementia show brain changes similar to Alzheimer’s in humans
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Study identifies molecular drivers of cerebral small vessel disease

  • December 16, 2025
A new study identifies molecular factors that promote small vessel disease – and an active drug that can…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Quitting smoking linked to slower memory decline in midlife and older adults
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Smoking fewer cigarettes does not eliminate cardiovascular disease risk

  • December 5, 2025
In a study funded by the National Heart, Lung, and Blood Institute, new research from Johns Hopkins Medicine…
SScience
Study: Multi-ancestry investigation of the genomics of erectile dysfunction. Image Credit: anastasy.a / Shutterstock
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Genetic signals reveal why erectile dysfunction develops and who is most at risk

  • November 26, 2025
New genomic evidence unmasks the biological pathways driving erectile dysfunction, linking cardiometabolic disease and addiction traits to ED…
HHealth
Disrupted brainstem-parahippocampal connectivity identified as a biomarker for delirium
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Stereotactic radiosurgery for craniopharyngioma management

  • November 20, 2025
Craniopharyngiomas account for 2–5% of all primary brain tumors and 5–10% of pediatric brain tumors. Despite their benign…
HHealth
Earlier blood transfusion reduces heart complications post-surgery in high-risk patients
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Earlier blood transfusion reduces heart complications post-surgery in high-risk patients

  • November 11, 2025
An earlier blood transfusion- done when hemoglobin levels were higher – after major general or vascular surgery among…
HHealth
New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy
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Diabetes drug blunts exercise-induced health improvements

  • November 7, 2025
A widely prescribed diabetes drug may be sabotaging one of the most trusted strategies for preventing the disease:…
HHealth
Predictable music phrases found to regulate blood pressure
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Adolescents who experience migraines more likely to have high blood pressure

  • November 6, 2025
A nationwide study from the Hebrew University of Jerusalem has found that adolescents who experience migraines are three…
HHealth
Cats with dementia show brain changes similar to Alzheimer’s in humans
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Survival patterns differ across types of early-onset dementia

  • November 5, 2025
The survival rates of people with early onset dementia-diagnosed before the age of 65-vary considerably by clinical type,…
HHealth
Heated tobacco and cigarettes cause the same gut and vascular damage, study finds
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Heated tobacco and cigarettes cause the same gut and vascular damage, study finds

  • November 4, 2025
Both traditional and heated tobacco exposure, whether active or passive, were linked to intestinal permeability, oxidative stress, and…
HHealth
Role of Circadian Health in Cardiometabolic Health and Disease Risk: A Scientific Statement From the American Heart Association. Credit: Billion Photos / Shutterstock
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Aligning your body clock may protect your heart and metabolism, says AHA

  • October 30, 2025
The American Heart Association warns that disrupted circadian rhythms, from irregular sleep, late-night meals, or shift work, can…
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