Although current guidelines recommend genetic counseling for all patients with early-onset or bilateral renal cell carcinoma (RCC), only 34% of eligible patients received a referral, according to findings from a recent study published in the Urologic Oncology.1<\/p>\n
In a recent interview with Urology Times\u00ae, senior author Hong Truong, MD, MS, broke down the key findings from the study. Truong is a urologic oncologist at Memorial Sloan Kettering Cancer Center in New York, New York.<\/p>\n
For the study, the investigators assessed data from 123 adult patients who received treatment for early-onset (46 years or younger) or bilateral RCC between 2017 and 2022. All patients included in the analysis met the criteria for genetic evaluation.<\/p>\n
Among all patients, 34% (n = 42) were referred for genetic counseling, 26% (n = 32) completed genetic counseling, and 22% (n = 27) underwent germline testing. In total, 24 patients had available genetic test results. Of those, 29% (n = 7) were found to have pathogenic or likely pathogenic variants, which included 2 patients (8%) who had variants in genes known to be associated with RCC.<\/p>\n
According to the authors, \u201cThese findings underscore a critical gap in the implementation of genetic evaluation guidelines and highlight opportunities to improve access and streamline referral pathways for patients with [kidney cancer].\u201d<\/p>\n
REFERENCE<\/p>\n
1. Makarova E, Bakhl K, Demirsoy S, et al. Utilization of genetic evaluation in patients with kidney cancer who meet guidelines for genetic referral. Urol Oncol. 2025:S1078-1439(25)00238-8. doi:10.1016\/j.urolonc.2025.06.009<\/p>\n","protected":false},"excerpt":{"rendered":"Although current guidelines recommend genetic counseling for all patients with early-onset or bilateral renal cell carcinoma (RCC), only…\n","protected":false},"author":2,"featured_media":111347,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[64,63,336,128,65792],"class_list":["post-111346","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-au","tag-australia","tag-genetics","tag-science","tag-urology-times"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/111346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=111346"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/111346\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/111347"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=111346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=111346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=111346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}