The Week 1 NFL schedule rolls on Friday with Chiefs vs. Chargers in Brazil at 8 p.m. ET. Thirteen games are on the Sunday schedule, with Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Packers at -2 versus the Lions. The Bills, meanwhile, are +1.5 against the Ravens in a Sunday Night Football showdown between AFC contenders. The week concludes with the Vikings (-1.5) visiting the Bears on Monday Night Football.\u00a0<\/p>\n
A set of exact Week 1 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL props you could target as well. Hitting on an exact NFL score prediction could also result in a huge payday. Before making any Week 1 NFL picks, be sure to\u00a0see the exact NFL score predictions from SportsLine expert Eric Cohen<\/a>.<\/p>\n A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight up NFL betting<\/a> picks (69%) and was profitable for bettors. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting<\/a>\u00a0sites and betting apps<\/a>.\u00a0You can only see Cohen’s Week 1 NFL exact score predictions at SportsLine<\/a>.<\/p>\n Also, new users can take advantage of the\u00a0DraftKings promo code<\/a>, which offers\u00a0$300 in bonus bets instantly plus over $200 off NFL Sunday Ticket<\/a>:<\/p>\n Top Week 1 NFL picks<\/p>\n After diving into all 16 games from the NFL’s Week 1, Cohen likes the Bills (+1.5, 50.5) to narrowly win a rematch of their AFC Divisional Playoff Game victory over the Ravens in a 26-23 final. “In my opinion, these are the two best teams in the NFL and we’ll see this matchup again on Sunday, January 25th, 2026 in the AFC Championship Game.”<\/p>\n “I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home field advantage ranking, the passionate Bills crowd would easily be in the top-5, if not No. 1 overall. That’s the difference in a game that should be very similar to last year’s playoff contest narrowly won by Buffalo.” With that score prediction, Cohen likes the Bills on the money line (-104), to cover the small spread and the Over to hit in this matchup, even though it is the highest total on the Week 1 NFL odds board.\u00a0See his other Week 1 football score predictions at SportsLine<\/a>.<\/p>\n How to make Week 1 NFL score predictions<\/p>\n In addition, Cohen is calling for one game to exceed 60 total points this week, making the Over a must bet. Nailing this result is key to making profitable Week 1 NFL picks. You can only see it at SportsLine<\/a>.<\/p>\n