{"id":190464,"date":"2025-10-04T23:37:52","date_gmt":"2025-10-04T23:37:52","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/190464\/"},"modified":"2025-10-04T23:37:52","modified_gmt":"2025-10-04T23:37:52","slug":"effect-of-tumor-draining-lymph-nodes-in-the-formation-and-maturation-of-tertiary-lymphoid-structure-in-patients-with-lung-adenocarcinoma-bmc-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/190464\/","title":{"rendered":"Effect of tumor draining lymph nodes in the formation and maturation of tertiary lymphoid structure in patients with lung adenocarcinoma | BMC Cancer"},"content":{"rendered":"

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17\u201348. https:\/\/doi.org\/10.3322\/caac.21763<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ribas A, Wolchok JD. Cancer immunotherapy using checkpoint Blockade. Science. 2018;359:1350\u20135. https:\/\/doi.org\/10.1126\/science.aar4060<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schumacher TN, Thommen DS. Tertiary lymphoid structures in cancer. Science. 2022;375:eabf9419. https:\/\/doi.org\/10.1126\/science.abf9419<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hugaboom MB, Wirth LV, Street K, Ruthen N, Jegede OA, Schindler NR, Shah V, Zaemes JP, El Ahmar N, Matar S, et al. Presence of tertiary lymphoid structures and exhausted Tissue-Resident T cells determines clinical response to PD-1 Blockade in renal cell carcinoma. Cancer Discov. 2025;15:948\u201368. https:\/\/doi.org\/10.1158\/2159-8290.CD-24-0991<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang E, Ma Y, Liu Z, Zhang J, Liu W, Chen Y, Liu G, Liu X, Zhang F, Zhu Y, et al. Prognostic implications and characterization of tumor-associated tertiary lymphoid structures genes in pancreatic cancer. J Transl Med. 2025;23:301. https:\/\/doi.org\/10.1186\/s12967-025-06152-8<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pradhan M, Kildal W, Vlatkovic L, Tobin KAR, Lindemann K, Kristensen GB, Kleppe A, Askautrud HA. Prognostic value of tertiary lymphoid structures in molecular subgroups of endometrial carcinoma. Int J Gynecol Cancer. 2025;35:101915. https:\/\/doi.org\/10.1016\/j.ijgc.2025.101915<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mi Z, Chen J, Zhang Z, Liu J, Lei Y, Tan H, Li W, Chen X, Rong P. Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer. Sci Transl Med. 2025;17: eado8395. https:\/\/doi.org\/10.1126\/scitranslmed.ado8395<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Su X, Kang D, Wang J, Li L, Huang R, Zou Z. Tertiary lymphoid structures associated with improved survival and enhanced antitumor immunity in acral melanoma. NPJ Precis Oncol. 2025;9:103. https:\/\/doi.org\/10.1038\/s41698-025-00891-z<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Su J-Y, Li J-R, Pan L-X, Ma Y-L, Tian W, Jiang Y-M, Guo P-P, Li L, Deng Z-J, Li Z-Z, et al. Tertiary lymphoid structures in hepatocellular carcinoma: influence on immune cell profiles in tumors and on efficacy of adjuvant PD-1 inhibitor therapy after hepatectomy. Hepatology. 2025. https:\/\/doi.org\/10.1097\/HEP.0000000000001433<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Guo Z, Feng H, Jia W, Zhang T, Chen M, Xu Z, Zheng F, Huang C, Li Z, Liu K, et al. Tertiary lymphoid structures signature predicts prognosis and clinical benefits from adjuvant chemotherapy and PD-L1 Blockade in colorectal adenocarcinoma. Int J Surg. 2025. https:\/\/doi.org\/10.1097\/JS9.0000000000002568<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Teillaud J-L, Houel A, Panouillot M, Riffard C, Dieu-Nosjean M-C. Tertiary lymphoid structures in anticancer immunity. Nat Rev Cancer. 2024;24:629\u201346. https:\/\/doi.org\/10.1038\/s41568-024-00728-0<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Munoz-Erazo L, Rhodes JL, Marion VC, Kemp RA. Tertiary lymphoid structures in cancer \u2013 considerations for patient prognosis. Cell Mol Immunol. 2020;17:570\u20135. https:\/\/doi.org\/10.1038\/s41423-020-0457-0<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Saut\u00e8s-Fridman C, Petitprez F, Calderaro J, Fridman WH. Tertiary lymphoid structures in the era of cancer immunotherapy. Nat Rev Cancer. 2019;19:307\u201325. https:\/\/doi.org\/10.1038\/s41568-019-0144-6<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sun X, Liu W, Sun L, Mo H, Feng Y, Wu X, Li C, Chen C, Li J, Xin Y, et al. Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer. J Immunother Cancer. 2022;10:e005531. https:\/\/doi.org\/10.1136\/jitc-2022-005531<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xin S, Wen S, He P, Zhao Y, Zhao H. Density of tertiary lymphoid structures and their correlation with prognosis in non-small cell lung cancer. Front Immunol. 2024;15:1423775. https:\/\/doi.org\/10.3389\/fimmu.2024.1423775<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

He M, He Q, Cai X, Liu J, Deng H, Li F, Zhong R, Lu Y, Peng H, Wu X, et al. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer. J Immunother Cancer. 2023;11:e005539. https:\/\/doi.org\/10.1136\/jitc-2022-005539<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hayashi Y, Makino T, Sato E, Ohshima K, Nogi Y, Kanemura T, Honma K, Yamashita K, Saito T, Tanaka K, et al. Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors. Br J Cancer. 2023;128:2175\u201385. https:\/\/doi.org\/10.1038\/s41416-023-02235-9<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xu F, Zhu H, Dong Y, Li L, Liu N, Yuan S. Combined inflammatory parameters and tertiary lymphoid structure predict prognosis in patients with resectable non-small cell lung cancer treated with neoadjuvant chemoimmunotherapy. Front Immunol. 2023;14:1244256. https:\/\/doi.org\/10.3389\/fimmu.2023.1244256<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bod L, Kye Y-C, Shi J, Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023. https:\/\/doi.org\/10.1038\/s41586-023-06231-0<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xie M, Lin X, Bao X, Liang Y, Deng H, Song J, Ma X, Zhang X, Yao J, Pan L, et al. Tertiary lymphoid structure in tumor microenvironment and immunotherapy of lung cancer. Arch Bronconeumol. 2024;60(Suppl 2):S77\u201385. https:\/\/doi.org\/10.1016\/j.arbres.2024.07.020<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang Y, Lin H, Yao N, Chen X, Qiu B, Cui Y, Liu Y, Li B, Han C, Li Z, et al. Computerized tertiary lymphoid structures density on H&E-images is a prognostic biomarker in resectable lung adenocarcinoma. iScience. 2023;26:107635. https:\/\/doi.org\/10.1016\/j.isci.2023.107635<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen Z, Wang X, Jin Z, Li B, Jiang D, Wang Y, Jiang M, Zhang D, Yuan P, Zhao Y, et al. Deep learning on tertiary lymphoid structures in hematoxylin-eosin predicts cancer prognosis and immunotherapy response. NPJ Precis Oncol. 2024;8:73. https:\/\/doi.org\/10.1038\/s41698-024-00579-w<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fukuhara M, Muto S, Inomata S, Yamaguchi H, Mine H, Takagi H, Ozaki Y, Watanabe M, Inoue T, Yamaura T, et al. The clinical significance of tertiary lymphoid structure and its relationship with peripheral blood characteristics in patients with surgically resected non-small cell lung cancer: a single-center, retrospective study. Cancer Immunol Immunother. 2022;71:1129\u201337. https:\/\/doi.org\/10.1007\/s00262-021-03067-3<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dieu-Nosjean M-C, Antoine M, Danel C, Heudes D, Wislez M, Poulot V, Rabbe N, Laurans L, Tartour E, de Chaisemartin L, et al. Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol. 2008;26:4410\u20137. https:\/\/doi.org\/10.1200\/JCO.2007.15.0284<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu X, Huang Q, Chen X, Zhang B, Liang J, Zhang B. B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications. Theranostics. 2025;15:605\u201331. https:\/\/doi.org\/10.7150\/thno.105423<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tian X, Zheng X, Tian D. B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy. Sig Transduct Target Ther. 2023;8:1\u20132. https:\/\/doi.org\/10.1038\/s41392-023-01643-w<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Balan S, Saxena M, Bhardwaj N. Dendritic cell subsets and locations. Int Rev Cell Mol Biol. 2019;348:1\u201368. https:\/\/doi.org\/10.1016\/bs.ircmb.2019.07.004<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Baba T, Ishizu A, Iwasaki S, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M. CD4+\/CD8\u2009+\u2009macrophages infiltrating at inflammatory sites: a population of monocytes\/macrophages with a cytotoxic phenotype. Blood. 2006;107:2004\u201312. https:\/\/doi.org\/10.1182\/blood-2005-06-2345<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17\u201348. https:\/\/doi.org\/10.3322\/caac.21763. Article\u00a0…\n","protected":false},"author":2,"featured_media":190465,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[64,63,5562,5563,1325,137,92009,120689,7407,5311,37704,104526,120688,120691,120690],"class_list":["post-190464","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-au","tag-australia","tag-biomedicine","tag-cancer-research","tag-general","tag-health","tag-health-promotion-and-disease-prevention","tag-maturation","tag-medicine-public-health","tag-oncology","tag-prognosis","tag-surgical-oncology","tag-tertiary-lymphoid-structure","tag-tim-1-b-cell","tag-tumor-immune-microenvironment"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/190464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=190464"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/190464\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/190465"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=190464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=190464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=190464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}