{"id":193266,"date":"2025-10-06T12:07:08","date_gmt":"2025-10-06T12:07:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/193266\/"},"modified":"2025-10-06T12:07:08","modified_gmt":"2025-10-06T12:07:08","slug":"trio-of-scientists-win-nobel-prize-in-medicine-for-discoveries-concerning-peripheral-immune-tolerance","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/193266\/","title":{"rendered":"Trio of scientists win Nobel Prize in Medicine for &#8216;discoveries concerning peripheral immune tolerance&#8217;"},"content":{"rendered":"<p class=\"paragraph_paragraph__iYReA\">Scientists Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have won the 2025 Nobel Prize in Physiology or Medicine for &#8220;their discoveries concerning peripheral immune tolerance&#8221;, the award-giving body said on Monday.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">The winners for medicine are selected by the Nobel Assembly of Sweden&#8217;s Karolinska Institute medical university and receive a prize sum of 11 million Swedish crowns ($1.7 million), as well as a gold medal presented by Sweden&#8217;s king.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">&#8220;Their discoveries have laid the foundation for a new field of research and spurred the development of new treatments, for example for cancer and autoimmune diseases,&#8221; the prize-awarding body said in a statement.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Ms Brunkow and Mr Ramsdell are based in the United States, and Mr Sakaguchi in Japan.<\/p>\n<p>&#8220;Their discoveries have laid the foundation for a new field of research and spurred the development of new treatments, for example for cancer and autoimmune diseases,&#8221;  the prize-awarding body said.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">The Nobel Prizes were established through the will of Alfred Nobel, the Swedish inventor of dynamite and a wealthy businessman.<\/p>\n<p><img decoding=\"async\" alt=\"A close-up of a stone bust of a bearded man.\" class=\"Image_image__5tFYM ContentImage_image__DQ_cq\"  src=\"https:\/\/www.newsbeep.com\/au\/wp-content\/uploads\/2025\/10\/ad4d4dc1542b33106c0f862889877636\" loading=\"lazy\" data-component=\"Image\" data-lazy=\"true\"\/><\/p>\n<p class=\"Typography_base__sj2RP FigureCaption_text__zDxQ5 Typography_sizeMobile12__w_FPC Typography_lineHeightMobile20___U7Vr Typography_regular__WeIG6 Typography_colourInherit__dfnUx\" data-component=\"Typography\">The Nobel Prizes were established through the will of Swedish inventor Alfred Nobel. (Reuters: Tom Little)<\/p>\n<p class=\"paragraph_paragraph__iYReA\">They have been awarded since 1901 for outstanding contributions in science, literature, and peace, with interruptions mainly during the World Wars.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">The economics prize was added later and is funded by Sweden&#8217;s central bank, the Riksbank.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Winners are selected by expert committees from various institutions.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">All prizes are awarded in Stockholm, except for the Peace Prize, which is presented in Oslo \u2014 a possible legacy of the political union between Sweden and Norway during Nobel&#8217;s lifetime.<\/p>\n<p><a href=\"https:\/\/www.abc.net.au\/news\/2023-10-02\/nobel-prize-physiology-medicine-2023-mrna-vaccine\/102926620\" data-component=\"FullBleedLink\" class=\"RelatedCard_link__rsgR9 FullBleedLink_root__lTw_U interactive_focusContext__yRhc_ interactive_defaults__AKxUU FullBleedLink_showVisited__g3Xvz\" rel=\"nofollow noopener\" target=\"_blank\">Nobel Prize for Medicine awarded to scientists whose work enabled mRNA COVID vaccines<\/a><\/p>\n<p class=\"Typography_base__sj2RP RelatedCard_synopsis__cFwMW Typography_sizeMobile14__u7TGe Typography_lineHeightMobile20___U7Vr Typography_regular__WeIG6 Typography_colourInherit__dfnUx\" data-component=\"Typography\">Scientists Katalin Karik\u00f3 and Drew Weissman won the 2023 Nobel Prize in Medicine for discoveries enabling the development of mRNA COVID-19 vaccines.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Past recipients of the Nobel Prize in Physiology or Medicine include renowned scientists such as Alexander Fleming, who shared the 1945 award for discovering penicillin.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">In recent years, the prize has recognised major breakthroughs, including those that enabled the development of COVID-19 vaccines.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Last year&#8217;s medicine prize was awarded to <a class=\"Link_link__kR0xA Link_link__5eL5m ScreenReaderOnly_srLinkHint__OysWz Link_showVisited__C1Fea Link_showFocus__ALyv2\" href=\"https:\/\/www.abc.net.au\/news\/2024-10-07\/us-duo-victor-ambros-and-gary-ruvkun-win-nobel-prize-in-medicine\/104442436\" data-component=\"Link\" data-uri=\"coremedia:\/\/article\/104442436\" rel=\"nofollow noopener\" target=\"_blank\">US scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA<\/a> and its key role in how multicellular organisms grow and live, helping explain how cells specialise into different types.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Medicine in accordance with tradition kicks off the annual Nobels, arguably the most prestigious prizes in science, literature, peace and economics, with the remainder set to be announced over the coming days.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">More than a century after their inception, the Nobel Prizes remain steeped in tradition. The awards culminate in ceremonies attended by the royal families of Sweden and Norway, followed by lavish banquets held on December 10 \u2014 the anniversary of Alfred Nobel&#8217;s death.<\/p>\n<p class=\"paragraph_paragraph__iYReA\">Reuters<\/p>\n","protected":false},"excerpt":{"rendered":"Scientists Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have won the 2025 Nobel Prize in Physiology or Medicine&hellip;\n","protected":false},"author":2,"featured_media":193267,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[43,20242,1679,44,22383,11750,122061,337,128,122062,41,39,42,40],"class_list":["post-193266","post","type-post","status-publish","format-standard","has-post-thumbnail","category-headlines","tag-headlines","tag-immunology","tag-medicine","tag-news","tag-nobel-prize","tag-physiology","tag-physiology-or-medicine","tag-research","tag-science","tag-science-awards","tag-top-news","tag-top-stories","tag-topnews","tag-topstories"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/193266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=193266"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/193266\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/193267"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=193266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=193266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=193266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}