NFL odds via DraftKings (unless otherwise noted). Bet\u00a0NFL<\/a>\u00a0Week 5 games and\u00a0NFL odds<\/a>\u00a0at\u00a0DraftKings<\/a>, where new users<\/a> get $200 in bonus bets with a winning $5 wager.<\/p>\n Sunday, 1 p.m. (Fox |\u00a0Fubo<\/a>, try for free)<\/p>\n We rode with the Jaguars in Week 5, and now we’re going to fade them a week later. While Jacksonville is one of the more surprising stories of the 2025 season thus far with a 4-1 record, I still have plenty of questions about them, particularly surrounding Trevor Lawrence<\/a>. He’s 24th among 33 qualified quarterbacks this season in EPA per dropback, and largely did his damage on Monday night with his legs. The passing left little to be desired outside of a couple of late throws to pull off the upset. The Jags are one of the top rushing offenses in the NFL<\/a>, but that plays into a key strength of the Seahawks. Seattle is giving up 3.3 yards per carry this season, which is second-best in the NFL. If that continues and they plug up the running lanes for Jacksonville, Lawrence’s passing deficiencies could be exposed.\u00a0<\/p>\n Also, let’s not ignore the tremendous season that Sam Darnold<\/a> is putting together for the Seahawks. Remarkably, his completion percentage and passer rating are even better than what he produced last season with the Vikings. I think he leads Seattle into Duval County and leaves with an outright win.\u00a0<\/p>\n Projected score: Seahawks 27, Jaguars 23 Sunday, 8:20 p.m. (NBC |\u00a0Fubo<\/a>, try for free)<\/p>\n The Chiefs will probably figure it out by the time the regular season comes to an end and will again look like a Super Bowl<\/a> contender, but I don’t see it right now. They are unable to hang with even fringe playoff contenders, with their two victories on the year coming against the New York Giants<\/a> and an injury-filled Baltimore Ravens<\/a> squad. When the games are close, they’ve fallen flat, owning a 0-3 record in one-score games this season. With this spread sitting at Chiefs -2.5, I think we’ll see more of the same. I have a hard time imagining this current version of the Chiefs offense keeping up with the Lions, who are averaging 34.8 points per game (most in the NFL). Dan Campbell’s team comes into Arrowhead Stadium with a 10-1 record on the road dating back to the start of last season. This could be another stellar showing from Detroit’s backfield duo of David Montgomery<\/a> and Jahmyr Gibbs<\/a> as they square off against a Chiefs run defense that is giving up 4.8 yards per carry (tied for fifth-highest in the NFL).<\/p>\n Projected score: Lions 30, Chiefs 23 Monday, 7:15 p.m. (ESPN |\u00a0Fubo<\/a>, try for free)<\/p>\n Buffalo got in its own way against the Patriots<\/a> on Sunday night, turning the ball over three times and committing 11 penalties. I’m not sure that happens two weeks in a row. The Bills have also responded well following defeats, as they are 4-1 both straight up and against the spread in their last five games after a loss. Buffalo still is averaging 30.6 points per game and 395.8 total yards per game this season, which rank third in the NFL. Despite the top-tier weapons at his disposal, I still have my doubts about Michael Penix Jr<\/a>. and his ability to go toe to toe with Josh Allen<\/a>.\u00a0<\/p>\n Projected score: Bills 33, Falcons 24 <\/p>\n Prisco’s Week 6 NFL picks: Desperate Chiefs win shootout vs. Lions, Chargers upset by Dolphins<\/p>\n \n Pete Prisco <\/p>\n <\/a> I’ve been high on Denver dating to the offseason, so I’m delighted that they are finally starting to look like themselves. They’ll look to carry the momentum from their comeback win over the Eagles<\/a> in Week 5 across the pond to London, where they will take on the New York Jets. This should be a lopsided matchup with New York still winless in 2025.\u00a0<\/p>\n One of the more surprising elements of the Jets poor start to the season is that they have yet to record a single turnover, which is blasphemous for an Aaron Glenn-led team. If that continues, Bo Nix<\/a> and the Broncos offense should have no problem getting into the end zone at least three times. If they do, that would almost automatically secure them the win. In his career, Justin Fields<\/a> is 0-26 when his opponent scores 21 or more points. For reference, Denver is averaging 23.4 points per game.<\/p>\n Meanwhile, favorites of seven or more points are 8-2 ATS all time in international games, so that’s another feather in our cap here. \u00a0 \u00a0<\/p>\n Projected score: Broncos 27, Jets 17 We talk a lot about how Mike Tomlin has never had a losing season as coach of the Pittsburgh Steelers. That’s certainly impressive, but as we look at this upcoming matchup against the Cleveland Browns, we’re highlighting another Tomlin-specific stat. The coach is 26-6 straight up in his career against rookie quarterbacks. That’s the second-best record by a coach with at least 15 games since 1970. History tells us he should have no problem diluting Dillon Gabriel’s<\/a> effectiveness in this game, and Pittsburgh’s 10 takeaways this season (second-most in the NFL) only emboldens us to lay the points in this spot. Don’t look now, but T.J. Watt<\/a> is also starting to heat up with three sacks in the last two games. That’s even worse news for Gabriel.\u00a0<\/p>\n Projected score: Steelers 24, Browns 16 Odds via\u00a0BetMGM<\/a>, where you can\u00a0get up to $1,500 back in bonus bets if your first football wager loses<\/a>.<\/p>\n Rest of the bunch<\/p>\n Cardinals<\/a> at Colts<\/a> Chargers<\/a> at Dolphins<\/a> Patriots at Saints<\/a> Cowboys<\/a> at Panthers<\/a> Rams<\/a> at Ravens Titans<\/a> at Raiders<\/a> Bengals<\/a> at Packers<\/a> 49ers<\/a> at Buccaneers<\/a> Bears<\/a> at Commanders<\/a>\u00a0(Monday)
The pick: Seahawks -1.5<\/p>\n
The pick:\u00a0Lions +2.5<\/p>\n
The pick:\u00a0Bills -4.5<\/p>\n![\"Prisco's](\"https:\/\/www.newsbeep.com\/au\/wp-content\/uploads\/2025\/10\/patrick-mahomes-imagn.jpg\")
<\/p>\n
\nSunday, 9:30 a.m. (NFL Network |\u00a0Fubo<\/a>, try for free)<\/p>\n
The pick:\u00a0Broncos -7.5<\/p>\n
The pick:\u00a0Steelers -5.5<\/p>\n
Projected score: Colts 30, Cardinals 21
The pick: Colts -7<\/p>\n
Projected score: Chargers 27, Dolphins 20
The pick: Chargers -4.5<\/p>\n
Projected score: Patriots 24, Saints 23
The pick: Saints +3.5<\/p>\n
Projected score: Cowboys 33, Panthers 23
The pick: Cowboys -3<\/p>\n
Projected score: Rams 30, Ravens 20
The pick: Rams -7<\/p>\n
Projected score: Raiders 24, Titans 20
The pick: Titans +4.5<\/p>\n
Projected score: Packers 30, Bengals 20
The pick: Bengals +14.5<\/p>\n
Projected score: Buccaneers 23, 49ers 21
The pick: 49ers +3.5<\/p>\n
Projected score: Commanders 28, Bears 23
The pick: Commanders -4.5<\/p>\n","protected":false},"excerpt":{"rendered":"We have ourselves another lengthy day of football in front of us. Once again, the action gets started…\n","protected":false},"author":2,"featured_media":207502,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[559],"tags":[1258,1276,64,63,631,17469,1261,1257,1248,1252,1238,1234,28660,1256,3055,1266,1243,1255,1246,1237,28657,6580,5368,1240,1250,3052,1263,1233,5346,1239,1231,1249,1242,1235,593,126454,128293,122199,122987,122988,1260,1241,1269,1262,1254,85,1284,1247,1253,6578,1272],"class_list":["post-207501","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nfl","tag-arizona-cardinals","tag-atlanta-falcons","tag-au","tag-australia","tag-baltimore-ravens","tag-bo-nix","tag-buffalo-bills","tag-carolina-panthers","tag-chicago-bears","tag-cincinnati-bengals","tag-cleveland-browns","tag-dallas-cowboys","tag-david-montgomery","tag-denver-broncos","tag-detroit-lions","tag-dillon-gabriel","tag-green-bay-packers","tag-houston-texans","tag-indianapolis-colts","tag-jacksonville-jaguars","tag-jahmyr-gibbs","tag-josh-allen","tag-justin-fields","tag-kansas-city-chiefs","tag-las-vegas-raiders","tag-los-angeles-chargers","tag-los-angeles-rams","tag-miami-dolphins","tag-michael-penix-jr","tag-minnesota-vikings","tag-new-england-patriots","tag-new-orleans-saints","tag-new-york-giants","tag-new-york-jets","tag-nfl","tag-nfl-week-6-best-bets","tag-nfl-week-6-locks","tag-nfl-week-6-odds","tag-nfl-week-6-picks","tag-nfl-week-6-predictions","tag-philadelphia-eagles","tag-pittsburgh-steelers","tag-sam-darnold","tag-san-francisco-49ers","tag-seattle-seahawks","tag-sports","tag-t-j-watt","tag-tampa-bay-buccaneers","tag-tennessee-titans","tag-trevor-lawrence","tag-washington-commanders"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/207501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=207501"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/207501\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/207502"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=207501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=207501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=207501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}