{"id":301316,"date":"2025-11-22T11:14:07","date_gmt":"2025-11-22T11:14:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/301316\/"},"modified":"2025-11-22T11:14:07","modified_gmt":"2025-11-22T11:14:07","slug":"ocular-manifestations-of-primary-thrombotic-microangiopathies-a-descriptive-systematic-review-bmc-ophthalmology","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/301316\/","title":{"rendered":"Ocular manifestations of primary thrombotic microangiopathies : a descriptive systematic review | BMC Ophthalmology"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Tsai H-M. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. Am J Med. 2013, Mar;126(3):200\u201309. <a href=\"https:\/\/doi.org\/10.1016\/j.amjmed.2012.09.006\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.amjmed.2012.09.006\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.amjmed.2012.09.006<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Untying%20the%20knot%20of%20thrombotic%20thrombocytopenic%20purpura%20and%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=Am%20J%20Med&amp;doi=10.1016%2Fj.amjmed.2012.09.006&amp;volume=126&amp;issue=3&amp;pages=200-09&amp;publication_year=2013&amp;author=Tsai%2CH-M\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Arnold DM, Patriquin CJ, Nazy I. Thrombotic microangiopathies: a general approach to diagnosis and management. C Can Med Assoc J = J l\u2019Assoc Medicale Can. 2017, Jan;189(4):E153\u201359. <a href=\"https:\/\/doi.org\/10.1503\/cmaj.160142\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1503\/cmaj.160142\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1503\/cmaj.160142<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20microangiopathies%3A%20a%20general%20approach%20to%20diagnosis%20and%20management&amp;journal=C%20Can%20Med%20Assoc%20J%20%3D%20J%20l%E2%80%99Assoc%20Medicale%20Can&amp;doi=10.1503%2Fcmaj.160142&amp;volume=189&amp;issue=4&amp;pages=E153-59&amp;publication_year=2017&amp;author=Arnold%2CDM&amp;author=Patriquin%2CCJ&amp;author=Nazy%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Thomas MR, Scully M. How I treat microangiopathic hemolytic anemia in patients with cancer. Blood. 2021, Mar;137(10):1310\u201317. <a href=\"https:\/\/doi.org\/10.1182\/blood.2019003810\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1182\/blood.2019003810\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1182\/blood.2019003810<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=How%20I%20treat%20microangiopathic%20hemolytic%20anemia%20in%20patients%20with%20cancer&amp;journal=Blood&amp;doi=10.1182%2Fblood.2019003810&amp;volume=137&amp;issue=10&amp;pages=1310-17&amp;publication_year=2021&amp;author=Thomas%2CMR&amp;author=Scully%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Scully M, et al. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012, Aug;158(3):323\u201335. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09167.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/j.1365-2141.2012.09167.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09167.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Guidelines%20on%20the%20diagnosis%20and%20management%20of%20thrombotic%20thrombocytopenic%20purpura%20and%20other%20thrombotic%20microangiopathies&amp;journal=Br%20J%20Haematol&amp;doi=10.1111%2Fj.1365-2141.2012.09167.x&amp;volume=158&amp;issue=3&amp;pages=323-35&amp;publication_year=2012&amp;author=Scully%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Legendre CM, et al.. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013, Jun;368(23):2169\u201381. <a href=\"https:\/\/doi.org\/10.1056\/NEJMoa1208981\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1056\/NEJMoa1208981\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1056\/NEJMoa1208981<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Terminal%20complement%20inhibitor%20eculizumab%20in%20atypical%20hemolytic-uremic%20syndrome&amp;journal=N%20Engl%20J%20Med&amp;doi=10.1056%2FNEJMoa1208981&amp;volume=368&amp;issue=23&amp;pages=2169-81&amp;publication_year=2013&amp;author=Legendre%2CCM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Adil SN, Karim F. Thrombotic microangiopathies: role of ADAMTS-13. JPMA The J Pak Med Assoc. 2012, Feb;62(2. Pakistan, pp. 91\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20microangiopathies%3A%20role%20of%20ADAMTS-13&amp;journal=JPMA%20The%20J%20Pak%20Med%20Assoc&amp;volume=62&amp;issue=2&amp;pages=91-92&amp;publication_year=2012&amp;author=Adil%2CSN&amp;author=Karim%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Tsai H-M. Autoimmune thrombotic microangiopathy: advances in pathogenesis, diagnosis, and management. Semin Thromb Hemost. 2012, Jul;38(5):469\u201382. <a href=\"https:\/\/doi.org\/10.1055\/s-0032-1306431\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1055\/s-0032-1306431\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1055\/s-0032-1306431<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autoimmune%20thrombotic%20microangiopathy%3A%20advances%20in%20pathogenesis%2C%20diagnosis%2C%20and%20management&amp;journal=Semin%20Thromb%20Hemost&amp;doi=10.1055%2Fs-0032-1306431&amp;volume=38&amp;issue=5&amp;pages=469-82&amp;publication_year=2012&amp;author=Tsai%2CH-M\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">L\u00e4mmle B, Kremer Hovinga JA, Alberio L. Thrombotic thrombocytopenic purpura. J Thromb Haemost. 2005, Aug;3(8):1663\u201375. <a href=\"https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01425.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/j.1538-7836.2005.01425.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01425.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20thrombocytopenic%20purpura&amp;journal=J%20Thromb%20Haemost&amp;doi=10.1111%2Fj.1538-7836.2005.01425.x&amp;volume=3&amp;issue=8&amp;pages=1663-75&amp;publication_year=2005&amp;author=L%C3%A4mmle%2CB&amp;author=Kremer%20Hovinga%2CJA&amp;author=Alberio%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Bhandari S, Kumar R. Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2019, Apr;380(16):e23. <a href=\"https:\/\/doi.org\/10.1056\/NEJMicm1813768\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1056\/NEJMicm1813768\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1056\/NEJMicm1813768<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20Thrombocytopenic%20Purpura&amp;journal=N%20Engl%20J%20Med&amp;doi=10.1056%2FNEJMicm1813768&amp;volume=380&amp;issue=16&amp;publication_year=2019&amp;author=Bhandari%2CS&amp;author=Kumar%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Zheng XL, et al. Isth guidelines for treatment of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020, Oct;18(10):2496\u2013502. <a href=\"https:\/\/doi.org\/10.1111\/jth.15010\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/jth.15010\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/jth.15010<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Isth%20guidelines%20for%20treatment%20of%20thrombotic%20thrombocytopenic%20purpura&amp;journal=J%20Thromb%20Haemost&amp;doi=10.1111%2Fjth.15010&amp;volume=18&amp;issue=10&amp;pages=2496-502&amp;publication_year=2020&amp;author=Zheng%2CXL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Coppo P, et al. A regimen with caplacizumab, immunosuppression, and plasma exchange prevents unfavorable outcomes in immune-mediated TTP. Blood. 2021, Feb;137(6):733\u201342. <a href=\"https:\/\/doi.org\/10.1182\/blood.2020008021\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1182\/blood.2020008021\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1182\/blood.2020008021<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20regimen%20with%20caplacizumab%2C%20immunosuppression%2C%20and%20plasma%20exchange%20prevents%20unfavorable%20outcomes%20in%20immune-mediated%20TTP&amp;journal=Blood&amp;doi=10.1182%2Fblood.2020008021&amp;volume=137&amp;issue=6&amp;pages=733-42&amp;publication_year=2021&amp;author=Coppo%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing escherichia coli and haemolytic uraemic syndrome. Lancet (lond, Engl). 2005, Mar;365(9464):1073\u201386. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(05)71144-2\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/S0140-6736(05)71144-2\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/S0140-6736(05)71144-2<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Shiga-toxin-producing%20escherichia%20coli%20and%20haemolytic%20uraemic%20syndrome&amp;journal=Lancet%20%28lond%2C%20Engl%29&amp;doi=10.1016%2FS0140-6736%2805%2971144-2&amp;volume=365&amp;issue=9464&amp;pages=1073-86&amp;publication_year=2005&amp;author=Tarr%2CPI&amp;author=Gordon%2CCA&amp;author=Chandler%2CWL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Noris M, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010, Oct;5(10):1844\u201359. <a href=\"https:\/\/doi.org\/10.2215\/CJN.02210310\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2215\/CJN.02210310\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2215\/CJN.02210310<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Relative%20role%20of%20genetic%20complement%20abnormalities%20in%20sporadic%20and%20familial%20aHUS%20and%20their%20impact%20on%20clinical%20phenotype&amp;journal=Clin%20J%20Am%20Soc%20Nephrol&amp;doi=10.2215%2FCJN.02210310&amp;volume=5&amp;issue=10&amp;pages=1844-59&amp;publication_year=2010&amp;author=Noris%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Pande A, Kumar A, Krishnani H, Acharya S, Shukla S. Recent advances in the management of microangiopathic hemolytic anemias (MAHA): a narrative review. Cureus. 2023, Oct;15(10):e47196. <a href=\"https:\/\/doi.org\/10.7759\/cureus.47196\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.7759\/cureus.47196\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.7759\/cureus.47196<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Recent%20advances%20in%20the%20management%20of%20microangiopathic%20hemolytic%20anemias%20%28maha%29%3A%20a%20narrative%20review&amp;journal=Cureus&amp;doi=10.7759%2Fcureus.47196&amp;volume=15&amp;issue=10&amp;publication_year=2023&amp;author=Pande%2CA&amp;author=Kumar%2CA&amp;author=Krishnani%2CH&amp;author=Acharya%2CS&amp;author=Shukla%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Iqbal S, Zaidi SZA, Motabi IH, Alshehry NF, AlGhamdi MS, Tailor IK. Thrombotic thrombocytopenic purpura &#8211; analysis of clinical features, laboratory characteristics and therapeutic outcome of 24 patients treated at a tertiary care center in Saudi Arabia. Pak J Med Sci. 2016;32(6):1494\u201399. <a href=\"https:\/\/doi.org\/10.12669\/pjms.326.11274\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.12669\/pjms.326.11274\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.12669\/pjms.326.11274<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20thrombocytopenic%20purpura%20-%20analysis%20of%20clinical%20features%2C%20laboratory%20characteristics%20and%20therapeutic%20outcome%20of%2024%20patients%20treated%20at%20a%20tertiary%20care%20center%20in%20Saudi%20Arabia&amp;journal=Pak%20J%20Med%20Sci&amp;doi=10.12669%2Fpjms.326.11274&amp;volume=32&amp;issue=6&amp;pages=1494-99&amp;publication_year=2016&amp;author=Iqbal%2CS&amp;author=Zaidi%2CSZA&amp;author=Motabi%2CIH&amp;author=Alshehry%2CNF&amp;author=AlGhamdi%2CMS&amp;author=Tailor%2CIK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Nguyen T, Radhakrishnan SM, Radhakrishnan SJ, Johnson DH. Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura. BMJ Case Rep. 2022, Feb;15(2). <a href=\"https:\/\/doi.org\/10.1136\/bcr-2021-244030\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/bcr-2021-244030\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/bcr-2021-244030<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Sheth KJ, Swick HM, Haworth N. Neurological involvement in hemolytic-uremic syndrome. Ann Neurol. 1986, Jan;19(1):90\u201393. <a href=\"https:\/\/doi.org\/10.1002\/ana.410190120\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/ana.410190120\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/ana.410190120<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neurological%20involvement%20in%20hemolytic-uremic%20syndrome&amp;journal=Ann%20Neurol&amp;doi=10.1002%2Fana.410190120&amp;volume=19&amp;issue=1&amp;pages=90-93&amp;publication_year=1986&amp;author=Sheth%2CKJ&amp;author=Swick%2CHM&amp;author=Haworth%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001, Sep;60(3):831\u201346. <a href=\"https:\/\/doi.org\/10.1046\/j.1523-1755.2001.060003831.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1046\/j.1523-1755.2001.060003831.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1046\/j.1523-1755.2001.060003831.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Thrombotic%20microangiopathy%2C%20hemolytic%20uremic%20syndrome%2C%20and%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Kidney%20Int&amp;doi=10.1046%2Fj.1523-1755.2001.060003831.x&amp;volume=60&amp;issue=3&amp;pages=831-46&amp;publication_year=2001&amp;author=Ruggenenti%2CP&amp;author=Noris%2CM&amp;author=Remuzzi%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Sturm V, Menke MN, Landau K, Laube GF, Neuhaus TJ. Ocular involvement in paediatric haemolytic uraemic syndrome. Acta Ophthalmol. 2010, Nov;88(7):804\u201307. <a href=\"https:\/\/doi.org\/10.1111\/j.1755-3768.2009.01552.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/j.1755-3768.2009.01552.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/j.1755-3768.2009.01552.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ocular%20involvement%20in%20paediatric%20haemolytic%20uraemic%20syndrome&amp;journal=Acta%20Ophthalmol&amp;doi=10.1111%2Fj.1755-3768.2009.01552.x&amp;volume=88&amp;issue=7&amp;pages=804-07&amp;publication_year=2010&amp;author=Sturm%2CV&amp;author=Menke%2CMN&amp;author=Landau%2CK&amp;author=Laube%2CGF&amp;author=Neuhaus%2CTJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Loudon SE, Dorresteijn EM, Catsman-Berrevoets CE, Verdijk RM, Simonsz HJ, Jansen AJG. Blinded by shiga toxin-producing O104 escherichia coli and hemolytic uremic syndrome. J Pediatr. 2014, Aug;165(2):410\u2013410.e1. <a href=\"https:\/\/doi.org\/10.1016\/j.jpeds.2014.04.008\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.jpeds.2014.04.008\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.jpeds.2014.04.008<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Blinded%20by%20shiga%20toxin-producing%20O104%20escherichia%20coli%20and%20hemolytic%20uremic%20syndrome&amp;journal=J%20Pediatr&amp;doi=10.1016%2Fj.jpeds.2014.04.008&amp;volume=165&amp;issue=2&amp;pages=410-410.e1&amp;publication_year=2014&amp;author=Loudon%2CSE&amp;author=Dorresteijn%2CEM&amp;author=Catsman-Berrevoets%2CCE&amp;author=Verdijk%2CRM&amp;author=Simonsz%2CHJ&amp;author=Jansen%2CAJG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">\u0421\u043c\u0438\u0440\u043d\u043e\u0432\u0430 \u0422\u0412, \u041a\u043e\u0437\u043b\u043e\u0432\u0441\u043a\u0430\u044f \u041d\u041b, \u0428\u0435\u043b\u0443\u0434\u0447\u0435\u043d\u043a\u043e \u0412\u041c. \u0413\u043b\u0430\u0437\u043d\u044b\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 \u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u0438\u043a\u0440\u043e\u0430\u043d\u0433\u0438\u043e\u043f\u0430\u0442\u0438\u0438. 2021.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Page MJ, et al. The prisma 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10(1):1\u201311. <a href=\"https:\/\/doi.org\/10.1186\/s13643-021-01626-4\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s13643-021-01626-4\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s13643-021-01626-4<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20prisma%202020%20statement%3A%20an%20updated%20guideline%20for%20reporting%20systematic%20reviews&amp;journal=Syst%20Rev&amp;doi=10.1186%2Fs13643-021-01626-4&amp;volume=10&amp;issue=1&amp;pages=1-11&amp;publication_year=2021&amp;author=Page%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Ma LL, Wang YY, Yang ZH, Huang D, Weng H, Zeng XT. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res. 2020;7(1):1\u201311. <a href=\"https:\/\/doi.org\/10.1186\/s40779-020-00238-8\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s40779-020-00238-8\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s40779-020-00238-8<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Methodological%20quality%20%28risk%20of%20bias%29%20assessment%20tools%20for%20primary%20and%20secondary%20medical%20studies%3A%20what%20are%20they%20and%20which%20is%20better%3F&amp;journal=Mil%20Med%20Res&amp;doi=10.1186%2Fs40779-020-00238-8&amp;volume=7&amp;issue=1&amp;pages=1-11&amp;publication_year=2020&amp;author=Ma%2CLL&amp;author=Wang%2CYY&amp;author=Yang%2CZH&amp;author=Huang%2CD&amp;author=Weng%2CH&amp;author=Zeng%2CXT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Lo CK-L, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers\u2019 to authors\u2019 assessments. BMC Med Res Methodol. 2014, Apr;14:45. <a href=\"https:\/\/doi.org\/10.1186\/1471-2288-14-45\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/1471-2288-14-45\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/1471-2288-14-45<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Newcastle-Ottawa%20Scale%3A%20comparing%20reviewers%E2%80%99%20to%20authors%E2%80%99%20assessments&amp;journal=BMC%20Med%20Res%20Methodol&amp;doi=10.1186%2F1471-2288-14-45&amp;volume=14&amp;publication_year=2014&amp;author=Lo%2CCK-L&amp;author=Mertz%2CD&amp;author=Loeb%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Stefani FH, Brandt F, Pielsticker K. Periarteritis nodosa and thrombotic thrombocytopenic purpura with serous retinal detachment in siblings. Br J Ophthalmol. 1978, Jun;62(6):402\u201307. <a href=\"https:\/\/doi.org\/10.1136\/bjo.62.6.402\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/bjo.62.6.402\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/bjo.62.6.402<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Periarteritis%20nodosa%20and%20thrombotic%20thrombocytopenic%20purpura%20with%20serous%20retinal%20detachment%20in%20siblings&amp;journal=Br%20J%20Ophthalmol&amp;doi=10.1136%2Fbjo.62.6.402&amp;volume=62&amp;issue=6&amp;pages=402-07&amp;publication_year=1978&amp;author=Stefani%2CFH&amp;author=Brandt%2CF&amp;author=Pielsticker%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Wyszynski RE, Frank KE, Grossniklaus HE. Bilateral retinal detachments in thrombotic thrombocytopenic purpura. Graefe\u2019s Arch Clin Exp Ophthalmol = Albr von Graefes Arch fur Klin und Exp Ophthalmol. 1988;226(6):501\u201304. <a href=\"https:\/\/doi.org\/10.1007\/BF02169195\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/BF02169195\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/BF02169195<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bilateral%20retinal%20detachments%20in%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Graefe%E2%80%99s%20Arch%20Clin%20Exp%20Ophthalmol%20%3D%20Albr%20von%20Graefes%20Arch%20fur%20Klin%20und%20Exp%20Ophthalmol&amp;doi=10.1007%2FBF02169195&amp;volume=226&amp;issue=6&amp;pages=501-04&amp;publication_year=1988&amp;author=Wyszynski%2CRE&amp;author=Frank%2CKE&amp;author=Grossniklaus%2CHE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Tajunisah I, Patel DK, Subrayan V. Purtscher retinopathy as an initial presentation of thrombotic thrombocytopenic purpura. J Thromb Thrombolysis. 2010, Jul;30(1):112\u201313. <a href=\"https:\/\/doi.org\/10.1007\/s11239-009-0399-y\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s11239-009-0399-y\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s11239-009-0399-y<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Purtscher%20retinopathy%20as%20an%20initial%20presentation%20of%20thrombotic%20thrombocytopenic%20purpura&amp;journal=J%20Thromb%20Thrombolysis&amp;doi=10.1007%2Fs11239-009-0399-y&amp;volume=30&amp;issue=1&amp;pages=112-13&amp;publication_year=2010&amp;author=Tajunisah%2CI&amp;author=Patel%2CDK&amp;author=Subrayan%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Williams PJ, Pearce WA, Smith JM, Robinson J. Profound visual recovery at 16 months after resolution of serous retinal detachments secondary to thrombotic thrombocytopenic purpura: case report and literature review. Retin Cases Brief Rep. 2021, Jan;15(1):18\u201321. <a href=\"https:\/\/doi.org\/10.1097\/ICB.0000000000000727\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/ICB.0000000000000727\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/ICB.0000000000000727<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Profound%20visual%20recovery%20at%2016%20months%20after%20resolution%20of%20serous%20retinal%20detachments%20secondary%20to%20thrombotic%20thrombocytopenic%20purpura%3A%20case%20report%20and%20literature%20review&amp;journal=Retin%20Cases%20Brief%20Rep&amp;doi=10.1097%2FICB.0000000000000727&amp;volume=15&amp;issue=1&amp;pages=18-21&amp;publication_year=2021&amp;author=Williams%2CPJ&amp;author=Pearce%2CWA&amp;author=Smith%2CJM&amp;author=Robinson%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Ustao\u011flu M, \u00d6nder F, Solmaz N, \u00d6zt\u00fcrk S, Ayer M. Purtscher-like retinopathy associated with atypical hemolytic uremic syndrome. Turk J Ophthalmol. 2017, Dec;47(6):348\u201350. <a href=\"https:\/\/doi.org\/10.4274\/tjo.66502\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.4274\/tjo.66502\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.4274\/tjo.66502<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Purtscher-like%20retinopathy%20associated%20with%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=Turk%20J%20Ophthalmol&amp;doi=10.4274%2Ftjo.66502&amp;volume=47&amp;issue=6&amp;pages=348-50&amp;publication_year=2017&amp;author=Ustao%C4%9Flu%2CM&amp;author=%C3%96nder%2CF&amp;author=Solmaz%2CN&amp;author=%C3%96zt%C3%BCrk%2CS&amp;author=Ayer%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Siegler RL, Brewer ED, Swartz M. Ocular involvement in hemolytic-uremic syndrome. J Pediatr. 1988, Apr;112(4):594\u201397. <a href=\"https:\/\/doi.org\/10.1016\/s0022-3476(88)80178-1\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/s0022-3476(88)80178-1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/s0022-3476(88)80178-1<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ocular%20involvement%20in%20hemolytic-uremic%20syndrome&amp;journal=J%20Pediatr&amp;doi=10.1016%2Fs0022-3476%2888%2980178-1&amp;volume=112&amp;issue=4&amp;pages=594-97&amp;publication_year=1988&amp;author=Siegler%2CRL&amp;author=Brewer%2CED&amp;author=Swartz%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Slusher MM, Pugh HP, Hackel RP. Bilateral serous retinal detachment in thrombotic thrombocytopenic purpura. Arch Ophthalmol (Chic, Ill. 1960), 1990 May;108(5):744\u201345. <a href=\"https:\/\/doi.org\/10.1001\/archopht.1990.01070070130050\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/archopht.1990.01070070130050\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/archopht.1990.01070070130050<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Sandhu H, Vavvas D. Bilateral tractional retinal detachment in a patient with hemolytic-uremic syndrome. J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus. 2015, Oct;19(5):484\u201386. <a href=\"https:\/\/doi.org\/10.1016\/j.jaapos.2015.05.017\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.jaapos.2015.05.017\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.jaapos.2015.05.017<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bilateral%20tractional%20retinal%20detachment%20in%20a%20patient%20with%20hemolytic-uremic%20syndrome&amp;journal=J%20AAPOS%20Off%20Publ%20Am%20Assoc%20Pediatr%20Ophthalmol%20Strabismus&amp;doi=10.1016%2Fj.jaapos.2015.05.017&amp;volume=19&amp;issue=5&amp;pages=484-86&amp;publication_year=2015&amp;author=Sandhu%2CH&amp;author=Vavvas%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Sampo M, Yin GHW, Hoffart L, Denis D, Soler V, Matonti F. Exudative retinal detachment treatment in a patient with thrombotic Thrombocytopenic Purpura. Case Rep Ophthalmol. 2016;7(1):90\u201395. <a href=\"https:\/\/doi.org\/10.1159\/000444291\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1159\/000444291\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1159\/000444291<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exudative%20retinal%20detachment%20treatment%20in%20a%20patient%20with%20thrombotic%20Thrombocytopenic%20Purpura&amp;journal=Case%20Rep%20Ophthalmol&amp;doi=10.1159%2F000444291&amp;volume=7&amp;issue=1&amp;pages=90-95&amp;publication_year=2016&amp;author=Sampo%2CM&amp;author=Yin%2CGHW&amp;author=Hoffart%2CL&amp;author=Denis%2CD&amp;author=Soler%2CV&amp;author=Matonti%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Santamar\u00eda \u00c1lvarez JF, Serret Camps A, Aguayo Alvarez J, Garc\u00eda Garc\u00eda O. Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome. Eur J Ophthalmol. 2020, May;30(3):NP14\u201317. <a href=\"https:\/\/doi.org\/10.1177\/1120672119833277\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1177\/1120672119833277\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1177\/1120672119833277<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Optic%20coherence%20tomography%20angiography%20follow-up%20in%20a%20case%20of%20Purtscher-like%20retinopathy%20due%20to%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=Eur%20J%20Ophthalmol&amp;doi=10.1177%2F1120672119833277&amp;volume=30&amp;issue=3&amp;pages=NP14-17&amp;publication_year=2020&amp;author=Santamar%C3%ADa%20%C3%81lvarez%2CJF&amp;author=Serret%20Camps%2CA&amp;author=Aguayo%20Alvarez%2CJ&amp;author=Garc%C3%ADa%20Garc%C3%ADa%2CO\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Ramos de Carvalho JE, Schlingemann RO, Oranje M, Bemelman FJ, van Schooneveld MJ. Reversal of threatening blindness after initiation of eculizumab in Purtscher-like retinopathy secondary to atypical hemolytic uremic syndrome. Int Ophthalmol. 2018, Feb;38(1):399\u2013407. <a href=\"https:\/\/doi.org\/10.1007\/s10792-017-0470-1\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s10792-017-0470-1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s10792-017-0470-1<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reversal%20of%20threatening%20blindness%20after%20initiation%20of%20eculizumab%20in%20Purtscher-like%20retinopathy%20secondary%20to%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=Int%20Ophthalmol&amp;doi=10.1007%2Fs10792-017-0470-1&amp;volume=38&amp;issue=1&amp;pages=399-407&amp;publication_year=2018&amp;author=Ramos%20de%20Carvalho%2CJE&amp;author=Schlingemann%2CRO&amp;author=Oranje%2CM&amp;author=Bemelman%2CFJ&amp;author=van%20Schooneveld%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Nagai T, Hasegawa O, Tuji A, Kamiyama Y, Honda M, Ito H. Pituitary hemorrhage in hemolytic uremic syndrome. Pediatr Neurol. 1992;8(1):75\u201376. <a href=\"https:\/\/doi.org\/10.1016\/0887-8994(92)90059-8\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/0887-8994(92)90059-8\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/0887-8994(92)90059-8<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pituitary%20hemorrhage%20in%20hemolytic%20uremic%20syndrome&amp;journal=Pediatr%20Neurol&amp;doi=10.1016%2F0887-8994%2892%2990059-8&amp;volume=8&amp;issue=1&amp;pages=75-76&amp;publication_year=1992&amp;author=Nagai%2CT&amp;author=Hasegawa%2CO&amp;author=Tuji%2CA&amp;author=Kamiyama%2CY&amp;author=Honda%2CM&amp;author=Ito%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Nanayakkara P, Gans RO, Reichert-Thoen J, Ter W. Pm. Serous retinal detachment as an early presentation of thrombotic thrombocytopenic purpura. Eur J Intern Med. 2000, Oct;11(5):286\u201388. <a href=\"https:\/\/doi.org\/10.1016\/s0953-6205(00)00109-6\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/s0953-6205(00)00109-6\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/s0953-6205(00)00109-6<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Serous%20retinal%20detachment%20as%20an%20early%20presentation%20of%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Eur%20J%20Intern%20Med&amp;doi=10.1016%2Fs0953-6205%2800%2900109-6&amp;volume=11&amp;issue=5&amp;pages=286-88&amp;publication_year=2000&amp;author=Nanayakkara%2CP&amp;author=Gans%2CRO&amp;author=Reichert-Thoen%2CJ&amp;author=Ter%20W.%20Pm%2C\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Mishra AV, Cadieux DC, Gjerde H, Lewis DR. Peripheral ulcerative keratitis secondary to atypical hemolytic uremic syndrome. Cornea. 2020, Nov;39(11):1431\u201332. <a href=\"https:\/\/doi.org\/10.1097\/ICO.0000000000002317\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/ICO.0000000000002317\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/ICO.0000000000002317<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Peripheral%20ulcerative%20keratitis%20secondary%20to%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=Cornea&amp;doi=10.1097%2FICO.0000000000002317&amp;volume=39&amp;issue=11&amp;pages=1431-32&amp;publication_year=2020&amp;author=Mishra%2CAV&amp;author=Cadieux%2CDC&amp;author=Gjerde%2CH&amp;author=Lewis%2CDR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Lin I-H, Chen Y-J, Chang P-Y, Hsiao P-W, Weng T-H, Chang Y-H. Bilateral proliferative retinopathy and ischemic optic neuropathy in a patient with atypical hemolytic-uremic syndrome: a case report. Med (baltim), vol. 2019, Sep;98(39):e17232. <a href=\"https:\/\/doi.org\/10.1097\/MD.0000000000017232\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/MD.0000000000017232\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/MD.0000000000017232<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bilateral%20proliferative%20retinopathy%20and%20ischemic%20optic%20neuropathy%20in%20a%20patient%20with%20atypical%20hemolytic-uremic%20syndrome%3A%20a%20case%20report&amp;journal=Med%20%28baltim%29&amp;doi=10.1097%2FMD.0000000000017232&amp;volume=98&amp;issue=39&amp;publication_year=2019&amp;author=Lin%2CI-H&amp;author=Chen%2CY-J&amp;author=Chang%2CP-Y&amp;author=Hsiao%2CP-W&amp;author=Weng%2CT-H&amp;author=Chang%2CY-H\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Ong T, Nolan W, Jagger J. Purtscher-like retinopathy as an initial presentation of thrombotic thrombocytopenic purpura: a case report. Eye (lond, Engl). 2005, Mar;19(3. England, pp. 359\u201361. <a href=\"https:\/\/doi.org\/10.1038\/sj.eye.6701491\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/sj.eye.6701491\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/sj.eye.6701491<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Purtscher-like%20retinopathy%20as%20an%20initial%20presentation%20of%20thrombotic%20thrombocytopenic%20purpura%3A%20a%20case%20report&amp;journal=Eye%20%28lond%2C%20Engl%29&amp;doi=10.1038%2Fsj.eye.6701491&amp;volume=19&amp;issue=3&amp;pages=359-61&amp;publication_year=2005&amp;author=Ong%2CT&amp;author=Nolan%2CW&amp;author=Jagger%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Larakeb A, et al. Ocular involvement in hemolytic uremic syndrome due to factor H deficiency\u2013are there therapeutic consequences? Pediatr Nephrol. 2007, Nov;22(11):1967\u201370. <a href=\"https:\/\/doi.org\/10.1007\/s00467-007-0540-0\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s00467-007-0540-0\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s00467-007-0540-0<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ocular%20involvement%20in%20hemolytic%20uremic%20syndrome%20due%20to%20factor%20H%20deficiency%E2%80%93are%20there%20therapeutic%20consequences%3F&amp;journal=Pediatr%20Nephrol&amp;doi=10.1007%2Fs00467-007-0540-0&amp;volume=22&amp;issue=11&amp;pages=1967-70&amp;publication_year=2007&amp;author=Larakeb%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Lambert SR, High KA, Cotlier E, Benz EJJ. Serous retinal detachments in thrombotic thrombocytopenic purpura. Arch Ophthalmol (Chic, Ill. 1960 1985, Aug;103(8):1172\u201374. <a href=\"https:\/\/doi.org\/10.1001\/archopht.1985.01050080084026\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/archopht.1985.01050080084026\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/archopht.1985.01050080084026<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Harris JA, Friedman MT, Varma M. Unilateral serous retinal detachment in a patient with thrombotic thrombocytopenic purpura. J Clin Apher. 2008;23(3):116\u201317. <a href=\"https:\/\/doi.org\/10.1002\/jca.20165\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/jca.20165\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/jca.20165<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unilateral%20serous%20retinal%20detachment%20in%20a%20patient%20with%20thrombotic%20thrombocytopenic%20purpura&amp;journal=J%20Clin%20Apher&amp;doi=10.1002%2Fjca.20165&amp;volume=23&amp;issue=3&amp;pages=116-17&amp;publication_year=2008&amp;author=Harris%2CJA&amp;author=Friedman%2CMT&amp;author=Varma%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Geraissate JC\u00c1, Yamamoto RE, Isaac DLC, de \u00c1vila MP. Hemorrhagic retinopathy in an infant with hemolytic-uremic syndrome. Arq Bras Oftalmol. 2014;77(6):397\u201399. <a href=\"https:\/\/doi.org\/10.5935\/0004-2749.20140099\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.5935\/0004-2749.20140099\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.5935\/0004-2749.20140099<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hemorrhagic%20retinopathy%20in%20an%20infant%20with%20hemolytic-uremic%20syndrome&amp;journal=Arq%20Bras%20Oftalmol&amp;doi=10.5935%2F0004-2749.20140099&amp;volume=77&amp;issue=6&amp;pages=397-99&amp;publication_year=2014&amp;author=Geraissate%2CJC%C3%81&amp;author=Yamamoto%2CRE&amp;author=Isaac%2CDLC&amp;author=de%20%C3%81vila%2CMP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Chodnicki KD, Brodsky MC, Olsen TW. Pigmented macular lesion in a child. JAMA Ophthalmol. 2019, Sep;137(9):1076\u201377. <a href=\"https:\/\/doi.org\/10.1001\/jamaophthalmol.2019.1659\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/jamaophthalmol.2019.1659\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/jamaophthalmol.2019.1659<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pigmented%20macular%20lesion%20in%20a%20child&amp;journal=JAMA%20Ophthalmol&amp;doi=10.1001%2Fjamaophthalmol.2019.1659&amp;volume=137&amp;issue=9&amp;pages=1076-77&amp;publication_year=2019&amp;author=Chodnicki%2CKD&amp;author=Brodsky%2CMC&amp;author=Olsen%2CTW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Gonz\u00e1lez DP, Iglicki M, Svetitsky S, Bar-On Y, Habot-Wilner Z, Zur D. Occlusive retinal vasculopathy with macular branch retinal artery occlusion as a leading sign of atypical hemolytic uremic syndrome &#8211; a case report. BMC Ophthalmol. 2021, Jan;21(1):65. <a href=\"https:\/\/doi.org\/10.1186\/s12886-021-01820-x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12886-021-01820-x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12886-021-01820-x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Occlusive%20retinal%20vasculopathy%20with%20macular%20branch%20retinal%20artery%20occlusion%20as%20a%20leading%20sign%20of%20atypical%20hemolytic%20uremic%20syndrome%20-%20a%20case%20report&amp;journal=BMC%20Ophthalmol&amp;doi=10.1186%2Fs12886-021-01820-x&amp;volume=21&amp;issue=1&amp;publication_year=2021&amp;author=Gonz%C3%A1lez%2CDP&amp;author=Iglicki%2CM&amp;author=Svetitsky%2CS&amp;author=Bar-On%2CY&amp;author=Habot-Wilner%2CZ&amp;author=Zur%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Spizzirri AP, et al. Ocular involvement in STEC-associated hemolytic uremic syndrome. Pediatr Nephrol. 2022, Nov;37(11):2699\u2013703. <a href=\"https:\/\/doi.org\/10.1007\/s00467-022-05587-1\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s00467-022-05587-1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s00467-022-05587-1<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ocular%20involvement%20in%20STEC-associated%20hemolytic%20uremic%20syndrome&amp;journal=Pediatr%20Nephrol&amp;doi=10.1007%2Fs00467-022-05587-1&amp;volume=37&amp;issue=11&amp;pages=2699-703&amp;publication_year=2022&amp;author=Spizzirri%2CAP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Costa JR, Krause M, Friedman E, D\u2019Amico DJ. Central retinal vein occlusion in a patient with thrombotic thrombocytopenic purpura. Am J Ophthalmol. 2001, May;131(5):669\u201371. <a href=\"https:\/\/doi.org\/10.1016\/s0002-9394(00)00875-8\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/s0002-9394(00)00875-8\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/s0002-9394(00)00875-8<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20retinal%20vein%20occlusion%20in%20a%20patient%20with%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Am%20J%20Ophthalmol&amp;doi=10.1016%2Fs0002-9394%2800%2900875-8&amp;volume=131&amp;issue=5&amp;pages=669-71&amp;publication_year=2001&amp;author=Costa%2CJR&amp;author=Krause%2CM&amp;author=Friedman%2CE&amp;author=D%E2%80%99Amico%2CDJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Corgier-Pattberg A, Beylerian M, Clave S, Cailliez M, Testud B, Desnous B. Threatening blindness in a child with typical hemolytic uremic syndrome. Pediatr Neurol. 2021, Sep;122:35\u201337. <a href=\"https:\/\/doi.org\/10.1016\/j.pediatrneurol.2021.06.008\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.pediatrneurol.2021.06.008\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.pediatrneurol.2021.06.008<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Threatening%20blindness%20in%20a%20child%20with%20typical%20hemolytic%20uremic%20syndrome&amp;journal=Pediatr%20Neurol&amp;doi=10.1016%2Fj.pediatrneurol.2021.06.008&amp;volume=122&amp;pages=35-37&amp;publication_year=2021&amp;author=Corgier-Pattberg%2CA&amp;author=Beylerian%2CM&amp;author=Clave%2CS&amp;author=Cailliez%2CM&amp;author=Testud%2CB&amp;author=Desnous%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Cat\u00f3n B, D\u00edaz de Otazu R, Aldamiz-Echebarria M, Viguri A. Haemolytic-uraemic syndrome with thrombotic microangiopathy of the retina following cytomegalovirus infection: postmortem findings. Postgrad Med J. 1993, Aug;69(814):653\u201355. <a href=\"https:\/\/doi.org\/10.1136\/pgmj.69.814.653\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/pgmj.69.814.653\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/pgmj.69.814.653<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Haemolytic-uraemic%20syndrome%20with%20thrombotic%20microangiopathy%20of%20the%20retina%20following%20cytomegalovirus%20infection%3A%20postmortem%20findings&amp;journal=Postgrad%20Med%20J&amp;doi=10.1136%2Fpgmj.69.814.653&amp;volume=69&amp;issue=814&amp;pages=653-55&amp;publication_year=1993&amp;author=Cat%C3%B3n%2CB&amp;author=D%C3%ADaz%20de%20Otazu%2CR&amp;author=Aldamiz-Echebarria%2CM&amp;author=Viguri%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Benvenuto F, Guillen S, Marchiscio L, Falbo J, Fandi\u00f1o A. Purtscher-like retinopathy in a paediatric patient with haemolytic uraemic syndrome: a case report and literature review. Arch Soc Esp Oftalmol. 2021, Nov;96(11):607\u201310. <a href=\"https:\/\/doi.org\/10.1016\/j.oftale.2020.10.007\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.oftale.2020.10.007\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.oftale.2020.10.007<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Purtscher-like%20retinopathy%20in%20a%20paediatric%20patient%20with%20haemolytic%20uraemic%20syndrome%3A%20a%20case%20report%20and%20literature%20review&amp;journal=Arch%20Soc%20Esp%20Oftalmol&amp;doi=10.1016%2Fj.oftale.2020.10.007&amp;volume=96&amp;issue=11&amp;pages=607-10&amp;publication_year=2021&amp;author=Benvenuto%2CF&amp;author=Guillen%2CS&amp;author=Marchiscio%2CL&amp;author=Falbo%2CJ&amp;author=Fandi%C3%B1o%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Power MH, Regillo MC, Custis PH. Thrombotic thrombocytopenic purpura associated with purtscher retinopathy. Arch Ophthalmol (Chic, Ill. 1960), 1997 Jan;115(1):128\u201329. <a href=\"https:\/\/doi.org\/10.1001\/archopht.1997.01100150130030\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/archopht.1997.01100150130030\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/archopht.1997.01100150130030<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Patel MR, Bains AK, O\u2019Hara JP, Kallab AM, Marcus DM. Purtscher retinopathy as the initial sign of thrombotic thrombocytopenic purpura\/hemolytic uremic syndrome. Arch Ophthalmol (Chic, Ill. 1960), 2001 Sep;119(9):1388\u201389. <a href=\"https:\/\/doi.org\/10.1001\/archopht.119.9.1388\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/archopht.119.9.1388\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/archopht.119.9.1388<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Agarwal A, Ram J. Pan-ocular hemorrhage in thrombotic thrombocytopenic purpura. Int J Hematol. 2014;99(5):527\u201328. <a href=\"https:\/\/doi.org\/10.1007\/s12185-014-1569-z\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s12185-014-1569-z\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s12185-014-1569-z<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pan-ocular%20hemorrhage%20in%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Int%20J%20Hematol&amp;doi=10.1007%2Fs12185-014-1569-z&amp;volume=99&amp;issue=5&amp;pages=527-28&amp;publication_year=2014&amp;author=Agarwal%2CA&amp;author=Ram%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Bandara AGNMK, Matthias AT. Retinal involvement in acute thrombotic thrombocytopenic purpura: a case report. BMC Ophthalmol. 2020, Nov;20(1):456. <a href=\"https:\/\/doi.org\/10.1186\/s12886-020-01719-z\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12886-020-01719-z\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12886-020-01719-z<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Retinal%20involvement%20in%20acute%20thrombotic%20thrombocytopenic%20purpura%3A%20a%20case%20report&amp;journal=BMC%20Ophthalmol&amp;doi=10.1186%2Fs12886-020-01719-z&amp;volume=20&amp;issue=1&amp;publication_year=2020&amp;author=Bandara%2CAGNMK&amp;author=Matthias%2CAT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Efthymiou M, et al. Comparison of real world and core laboratory lupus anticoagulant results from the Antiphospholipid syndrome Alliance for clinical trials and international networking (aps action) clinical database and repository. J Thromb Haemost. 2019, Dec;17(12):2069\u201380. <a href=\"https:\/\/doi.org\/10.1111\/jth.14596\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/jth.14596\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/jth.14596<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Comparison%20of%20real%20world%20and%20core%20laboratory%20lupus%20anticoagulant%20results%20from%20the%20Antiphospholipid%20syndrome%20Alliance%20for%20clinical%20trials%20and%20international%20networking%20%28aps%20action%29%20clinical%20database%20and%20repository&amp;journal=J%20Thromb%20Haemost&amp;doi=10.1111%2Fjth.14596&amp;volume=17&amp;issue=12&amp;pages=2069-80&amp;publication_year=2019&amp;author=Efthymiou%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Melton RC, Spaide RF. Visual problems as a presenting sign of thrombotic thrombocytopenic purpura. Retina. 1996;16(1):78\u201380. <a href=\"https:\/\/doi.org\/10.1097\/00006982-199616010-00016\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/00006982-199616010-00016\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/00006982-199616010-00016<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Visual%20problems%20as%20a%20presenting%20sign%20of%20thrombotic%20thrombocytopenic%20purpura&amp;journal=Retina&amp;doi=10.1097%2F00006982-199616010-00016&amp;volume=16&amp;issue=1&amp;pages=78-80&amp;publication_year=1996&amp;author=Melton%2CRC&amp;author=Spaide%2CRF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Miguel AIM, Henriques F, Azevedo LFR, Loureiro AJR, Maberley DAL. Systematic review of Purtscher\u2019s and Purtscher-like retinopathies. Eye (Lond), vol. 2013 Jan;27(1):1\u201313. <a href=\"https:\/\/doi.org\/10.1038\/eye.2012.222\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/eye.2012.222\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/eye.2012.222<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Systematic%20review%20of%20Purtscher%E2%80%99s%20and%20Purtscher-like%20retinopathies&amp;journal=Eye%20%28Lond%29&amp;doi=10.1038%2Feye.2012.222&amp;volume=27&amp;issue=1&amp;pages=1-13&amp;publication_year=2013&amp;author=Miguel%2CAIM&amp;author=Henriques%2CF&amp;author=Azevedo%2CLFR&amp;author=Loureiro%2CAJR&amp;author=Maberley%2CDAL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Serhan HA, et al. Purtscher\u2019s and Purtscher-like retinopathy etiology, features, management, and outcomes: a summative systematic review of 168 cases. PLoS One. 2024;19(9):e0306473. <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0306473\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1371\/journal.pone.0306473\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1371\/journal.pone.0306473<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Purtscher%E2%80%99s%20and%20Purtscher-like%20retinopathy%20etiology%2C%20features%2C%20management%2C%20and%20outcomes%3A%20a%20summative%20systematic%20review%20of%20168%20cases&amp;journal=PLoS%20One&amp;doi=10.1371%2Fjournal.pone.0306473&amp;volume=19&amp;issue=9&amp;publication_year=2024&amp;author=Serhan%2CHA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR60\">David R, Hochberg-Klein S, Amer R. Resolution of ocular involvement with systemic eculizumab therapy in atypical hemolytic-uremic syndrome. Eye (lond, Engl). 2013, Aug;27(8). England, pp. 997\u201398. <a href=\"https:\/\/doi.org\/10.1038\/eye.2013.111\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/eye.2013.111\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/eye.2013.111<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Resolution%20of%20ocular%20involvement%20with%20systemic%20eculizumab%20therapy%20in%20atypical%20hemolytic-uremic%20syndrome&amp;journal=Eye%20%28lond%2C%20Engl%29&amp;doi=10.1038%2Feye.2013.111&amp;volume=27&amp;issue=8&amp;pages=997-98&amp;publication_year=2013&amp;author=David%2CR&amp;author=Hochberg-Klein%2CS&amp;author=Amer%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Zheng X, Gorovoy IR, Mao J, Jin J, Chen X, Cui QN. Recurrent ocular involvement in pediatric atypical hemolytic uremic syndrome. J Pediatr Ophthalmol Strabismus. 2014 Oct;51:pp. e 62\u20135. <a href=\"https:\/\/doi.org\/10.3928\/01913913-20140923-03\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3928\/01913913-20140923-03\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3928\/01913913-20140923-03<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Recurrent%20ocular%20involvement%20in%20pediatric%20atypical%20hemolytic%20uremic%20syndrome&amp;journal=J%20Pediatr%20Ophthalmol%20Strabismus&amp;doi=10.3928%2F01913913-20140923-03&amp;volume=51&amp;pages=pp.%20e%2062-5&amp;publication_year=2014&amp;author=Zheng%2CX&amp;author=Gorovoy%2CIR&amp;author=Mao%2CJ&amp;author=Jin%2CJ&amp;author=Chen%2CX&amp;author=Cui%2CQN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The prisma 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. <a href=\"https:\/\/doi.org\/10.1136\/bmj.n71\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/bmj.n71\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/bmj.n71<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20prisma%202020%20statement%3A%20an%20updated%20guideline%20for%20reporting%20systematic%20reviews&amp;journal=BMJ&amp;doi=10.1136%2Fbmj.n71&amp;volume=372&amp;publication_year=2021&amp;author=Page%2CMJ&amp;author=McKenzie%2CJE&amp;author=Bossuyt%2CPM&amp;author=Boutron%2CI&amp;author=Hoffmann%2CTC&amp;author=Mulrow%2CCD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Tsai H-M. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. Am J Med. 2013,&hellip;\n","protected":false},"author":2,"featured_media":301317,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[64,63,172185,172181,27391,172184,172183,105,172182],"class_list":{"0":"post-301316","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-au","9":"tag-australia","10":"tag-capillary-non-perfusion","11":"tag-ocular-manifestations","12":"tag-ophthalmology","13":"tag-purtscher-like-retinopathy","14":"tag-retinal-hemorrhages","15":"tag-technology","16":"tag-thrombotic-microangiopathy"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/301316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=301316"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/301316\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/301317"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=301316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=301316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=301316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}