{"id":306961,"date":"2025-11-25T04:17:04","date_gmt":"2025-11-25T04:17:04","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/306961\/"},"modified":"2025-11-25T04:17:04","modified_gmt":"2025-11-25T04:17:04","slug":"platelet-to-hemoglobin-ratio-as-a-novel-prognostic-biomarker-in-sepsis-associated-aki-a-multicenter-cohort-study-bmc-nephrology","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/306961\/","title":{"rendered":"Platelet-to-hemoglobin ratio as a novel prognostic biomarker in sepsis-associated AKI: a multicenter cohort study | BMC Nephrology"},"content":{"rendered":"

Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. Feb 23 2016;315(8):801\u2009\u2013\u200910. https:\/\/doi.org\/10.1001\/jama.2016.0287<\/a><\/p>\n

Peerapornratana S, Manrique-Caballero CL, G\u00f3mez H, Kellum JA. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. Nov 2019;96(5):1083\u201399. https:\/\/doi.org\/10.1016\/j.kint.2019.05.026<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pais T, Jorge S, Lopes JA. Acute kidney injury in sepsis. Int J Mol Sci. May 2024;29(11). https:\/\/doi.org\/10.3390\/ijms25115924<\/a>.<\/p>\n

Zarbock A, Nadim MK, Pickkers P, et al. Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup. Nat Rev Nephrol. Jun 2023;19(6):401\u201317. https:\/\/doi.org\/10.1038\/s41581-023-00683-3<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bao K, Huang H, Huang G, Wang J, Liao Y, Pan Y, Chen W, Lu J, Yang Y, Huang Z, Chen S, Chen K, Chen L. Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-cause mortality in coronary artery disease patients with congestive heart failure. BMC Cardiovasc Disord. 2021;21(1):618.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Thiery-Antier N, Binquet C, Vinault S, Meziani F, Boisram\u00e9-Helms J, Quenot JP. Is thrombocytopenia an early prognostic marker in septic shock? Crit Care Med. Apr 2016;44(4):764\u201372. https:\/\/doi.org\/10.1097\/ccm.0000000000001520<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Giustozzi M, Ehrlinder H, Bongiovanni D, et al. Coagulopathy and sepsis: pathophysiology, clinical manifestations and treatment. Blood Rev. Nov 2021;50:100864. https:\/\/doi.org\/10.1016\/j.blre.2021.100864<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sang Y, Roest M, de Laat B, de Groot PG, Huskens D. Interplay between platelets and coagulation. Blood Rev. Mar 2021;46:100733. https:\/\/doi.org\/10.1016\/j.blre.2020.100733<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Muady GF, Bitterman H, Laor A, Vardi M, Urin V, Ghanem-Zoubi N. Hemoglobin levels and blood transfusion in patients with sepsis in internal medicine departments. BMC Infect Dis. Oct 2016;13(1):569. https:\/\/doi.org\/10.1186\/s12879-016-1882-7<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hemauer SJ, Kingeter AJ, Han X, Shotwell MS, Pandharipande PP, Weavind LM. Daily lowest hemoglobin and risk of organ dysfunctions in critically ill patients. Crit Care Med. May 2017;45(5):e479\u201384. https:\/\/doi.org\/10.1097\/ccm.0000000000002288<\/a>.<\/p>\n

Johnson AEW, Bulgarelli L, Shen L, et al. MIMIC-IV, a freely accessible electronic health record dataset. Sci Data. Jan 3. 2023;10(1):1. https:\/\/doi.org\/10.1038\/s41597-022-01899-x<\/a><\/p>\n

Pollard TJ, Johnson AEW, Raffa JD, Celi LA, Mark RG, Badawi O. The eICU collaborative research database, a freely available multi-center database for critical care research. Sci Data. Sep 2018;11:5:180178. https:\/\/doi.org\/10.1038\/sdata.2018.178<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. Feb 23 2016;315(8):762\u2009\u2013\u200974. https:\/\/doi.org\/10.1001\/jama.2016.0288<\/a><\/p>\n

Ostermann M, Bellomo R, Burdmann EA, et al. Aug. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2020;98(2):294\u2013309. https:\/\/doi.org\/10.1016\/j.kint.2020.04.020<\/a><\/p>\n

Cox D. Sepsis – it is all about the platelets. Front Immunol. 2023;14:1210219. https:\/\/doi.org\/10.3389\/fimmu.2023.1210219<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vandijck DM, Blot SI, De Waele JJ, Hoste EA, Vandewoude KH, Decruyenaere JM. Thrombocytopenia and outcome in critically ill patients with bloodstream infection. Heart Lung. Jan-Feb 2010;39(1):21\u20136. https:\/\/doi.org\/10.1016\/j.hrtlng.2009.07.005<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Johansson D, Rasmussen M, Inghammar M. Thrombocytopenia in bacteraemia and association with bacterial species. Epidemiol Infect. Jul 2018;146(10):1312\u20137. https:\/\/doi.org\/10.1017\/s0950268818001206<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Semeraro F, Colucci M, Caironi P, et al. Platelet drop and fibrinolytic shutdown in patients with sepsis. Crit Care Med. Mar 2018;46(3):e221\u20138. https:\/\/doi.org\/10.1097\/ccm.0000000000002919<\/a>.<\/p>\n

Hayden SJ, Albert TJ, Watkins TR, Swenson ER. Anemia in critical illness: insights into etiology, consequences, and management. Am J Respir Crit Care Med. May 2012;15(10):1049\u201357. https:\/\/doi.org\/10.1164\/rccm.201110-1915CI<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related organ failure Assessment) score to describe organ dysfunction\/failure. On behalf of the working group on Sepsis-Related problems of the European society of intensive care medicine. Intensive Care Med. Jul 1996;22(7):707\u201310. https:\/\/doi.org\/10.1007\/bf01709751<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

I\u015f\u0131k F, Soner S. Platelet-to-Hemoglobin ratio is an important predictor of in-hospital mortality in patients with ST-segment elevation myocardial infarction. Cureus. Jul 2022;14(7):e26833. https:\/\/doi.org\/10.7759\/cureus.26833<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bao K, Huang H, Huang G, et al. Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-cause mortality in coronary artery disease patients with congestive heart failure. BMC Cardiovasc Disord. Dec 2021;28(1):618. https:\/\/doi.org\/10.1186\/s12872-021-02423-6<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care. 2013;1(1):9. https:\/\/doi.org\/10.1186\/2052-0492-1-9<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhu J, Dong Y, Liao P, Yin X, He J, Guo L. Prognostic value of hemoglobin in patients with sepsis: a systematic review and meta-analysis. Heart Lung. Mar-Apr 2024;64:93\u20139. https:\/\/doi.org\/10.1016\/j.hrtlng.2023.12.001<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Giustino G, Kirtane AJ, Baber U, et al. Impact of anemia on platelet reactivity and ischemic and bleeding risk: from the assessment of dual antiplatelet therapy with Drug-Eluting stents study. Am J Cardiol. Jun 2016;15(12):1877\u201383. https:\/\/doi.org\/10.1016\/j.amjcard.2016.03.034<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang S, Guo R, Liu Y, et al. Basic and applied research progress of TRAIL in hematologic malignancies. Blood Sci. 2025;7(2):e00221. https:\/\/doi.org\/10.1097\/BS9.0000000000000221<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hidalgo JL, Kumar VK, Akech SO, et al. The sepsis chain of survival: a comprehensive framework for improving sepsis outcomes. Crit Care Med. 2025;53(10):e1886\u201392. https:\/\/doi.org\/10.1097\/CCM.0000000000006796<\/a>.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock…\n","protected":false},"author":2,"featured_media":299228,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[165951,64,63,137,27394,28761,174688,110149],"class_list":{"0":"post-306961","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-acute-kidney-injury","9":"tag-au","10":"tag-australia","11":"tag-health","12":"tag-internal-medicine","13":"tag-nephrology","14":"tag-platelet-to-hemoglobin-ratio-phr","15":"tag-sepsis"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/306961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=306961"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/306961\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/299228"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=306961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=306961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=306961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}