{"id":315125,"date":"2025-11-28T21:42:08","date_gmt":"2025-11-28T21:42:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/315125\/"},"modified":"2025-11-28T21:42:08","modified_gmt":"2025-11-28T21:42:08","slug":"neuroblastoma-treatment-could-be-found-in-new-drug-according-to-research","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/315125\/","title":{"rendered":"Neuroblastoma treatment could be found in new drug, according to research"},"content":{"rendered":"<p>A drug already approved for cancer treatment could now help treat a deadly childhood cancer, Australian research has revealed.<\/p>\n<p>Neuroblastoma is a tumour that develops from nerve cells glands above the kidneys, or along the spine, chest and abdomen; it occurs commonly in children, and is deadly in nine out of 10 cases when children relapse.<\/p>\n<p>This is most common in high-risk neuroblastoma, where 15 per cent of children do not respond to treatment, and half of those who do respond initially will see their cancer return.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.newsbeep.com\/au\/wp-content\/uploads\/2025\/11\/https:\/\/prod.static9.net.au\/fs\/55885345-e406-4cad-afc0-9b19d04c6919.jpeg\"   alt=\"Neuroblastoma is a deadly cancer that can affect children as young as two-years-old. A new study by the Garvan Institute may have found a drug that can help cure it.\"\/>Neuroblastoma is a deadly cancer that can affect children as young as two-years-old. (Garvan Institute)<\/p>\n<p>This is because standard drugs used in chemotherapy rely on the same cellular switch, called the JNK pathway, to kill the cancer cells.\u00a0<\/p>\n<p>In relapsed tumours, the JNK cells can stop working, making treatments ineffective and causing the tumours to spread with deadly consequences.<\/p>\n<p>&#8220;The statistics once patients get to that point are devastating for families,&#8221; Associate Professor David Croucher said.<\/p>\n<p>However, researchers at the Garvan Institute have found a drug called romidepsin can help reduce tumour growth and the chances of the deadly cancer returning, helping more children survive.<\/p>\n<p>The drug is already approved to treat other cancers like lymphomas, and the result of the study published in Science Advances is promising, according to researchers.<\/p>\n<p>&#8220;This represents a big step forward,&#8221; Croucher said.<\/p>\n<p>&#8220;By finding drugs that don&#8217;t depend on the JNK pathway, we can still trigger cancer cell death even when this usual route is blocked.&#8221;<\/p>\n<p>The trials were conducted on animal models, and the next step is to use clinical trials.<\/p>\n<p>Crocuher insists the benefits will be of the families who could be helped fight the devastating disease.<\/p>\n<p>&#8220;Behind every statistic is someone&#8217;s loved one,&#8221; Croucher said. &#8220;Understanding these molecular mechanisms gives us hope we can develop more effective treatments for patients and their families who currently face limited options \u2013 and that&#8217;s what drives us every day.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"A drug already approved for cancer treatment could now help treat a deadly childhood cancer, Australian research has&hellip;\n","protected":false},"author":2,"featured_media":315126,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[43,44,41,39,42,40],"class_list":{"0":"post-315125","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-headlines","8":"tag-headlines","9":"tag-news","10":"tag-top-news","11":"tag-top-stories","12":"tag-topnews","13":"tag-topstories"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/315125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=315125"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/315125\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/315126"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=315125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=315125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=315125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}