{"id":33459,"date":"2025-07-30T22:15:07","date_gmt":"2025-07-30T22:15:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/33459\/"},"modified":"2025-07-30T22:15:07","modified_gmt":"2025-07-30T22:15:07","slug":"specific-targeting-of-adipose-tissue-metabolism-is-superior-to-caloric-restriction-in-treating-obesity-related-hfpef-cardiovascular-diabetology","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/33459\/","title":{"rendered":"Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF | Cardiovascular Diabetology"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Koskinas KC, Van Craenenbroeck EM, Antoniades C, Bl\u00fcher M, Gorter TM, Hanssen H, et al. Obesity and cardiovascular disease: an ESC clinical consensus statement. Eur Heart J. 2024;45:4063\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXht1yksro%3D\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Obesity%20and%20cardiovascular%20disease%3A%20an%20ESC%20clinical%20consensus%20statement&amp;journal=Eur%20Heart%20J&amp;volume=45&amp;pages=4063-4098&amp;publication_year=2024&amp;author=Koskinas%2CKC&amp;author=Craenenbroeck%2CEM&amp;author=Antoniades%2CC&amp;author=Bl%C3%BCher%2CM&amp;author=Gorter%2CTM&amp;author=Hanssen%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Ruperez C, Madeo F, De Cabo R, Kroemer G, Abdellatif M. Obesity accelerates cardiovascular ageing. Eur Heart J. 2025;ehaf216.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Leggat J, Bidault G, Vidal-Puig A. Lipotoxicity: a driver of heart failure with preserved ejection fraction? Clin Sci Lond Engl. 1979;2021(135):2265\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lipotoxicity%3A%20a%20driver%20of%20heart%20failure%20with%20preserved%20ejection%20fraction%3F&amp;journal=Clin%20Sci%20Lond%20Engl&amp;volume=2021&amp;issue=135&amp;pages=2265-2283&amp;publication_year=1979&amp;author=Leggat%2CJ&amp;author=Bidault%2CG&amp;author=Vidal-Puig%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Abdellatif M, Kroemer G. Heart failure with preserved ejection fraction: an age-related condition. J Mol Cell Cardiol. 2022;S0022\u20132828(22):00052\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Heart%20failure%20with%20preserved%20ejection%20fraction%3A%20an%20age-related%20condition&amp;journal=J%20Mol%20Cell%20Cardiol&amp;volume=S0022%E2%80%932828&amp;issue=22&amp;pages=00052-59&amp;publication_year=2022&amp;author=Abdellatif%2CM&amp;author=Kroemer%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Fuerlinger A, Stockner A, Sedej S, Abdellatif M. Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential. Cardiovasc Diabetol. 2025;24:21.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Caloric%20restriction%20and%20its%20mimetics%20in%20heart%20failure%20with%20preserved%20ejection%20fraction%3A%20mechanisms%20and%20therapeutic%20potential&amp;journal=Cardiovasc%20Diabetol&amp;volume=24&amp;publication_year=2025&amp;author=Fuerlinger%2CA&amp;author=Stockner%2CA&amp;author=Sedej%2CS&amp;author=Abdellatif%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Borlaug BA, Jensen MD, Kitzman DW, Lam CSP, Obokata M, Rider OJ. Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets. Cardiovasc Res. 2023;118:3434\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Obesity%20and%20heart%20failure%20with%20preserved%20ejection%20fraction%3A%20new%20insights%20and%20pathophysiological%20targets&amp;journal=Cardiovasc%20Res&amp;volume=118&amp;pages=3434-3450&amp;publication_year=2023&amp;author=Borlaug%2CBA&amp;author=Jensen%2CMD&amp;author=Kitzman%2CDW&amp;author=Lam%2CCSP&amp;author=Obokata%2CM&amp;author=Rider%2COJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G, Kraus WE, et al. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2016;315:36\u201346.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhtVartbbK\" aria-label=\"CAS reference 7\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20caloric%20restriction%20or%20aerobic%20exercise%20training%20on%20peak%20oxygen%20consumption%20and%20quality%20of%20life%20in%20obese%20older%20patients%20with%20heart%20failure%20with%20preserved%20ejection%20fraction%3A%20a%20randomized%20clinical%20trial&amp;journal=JAMA&amp;volume=315&amp;pages=36-46&amp;publication_year=2016&amp;author=Kitzman%2CDW&amp;author=Brubaker%2CP&amp;author=Morgan%2CT&amp;author=Haykowsky%2CM&amp;author=Hundley%2CG&amp;author=Kraus%2CWE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">O\u2019Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, et al. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. Lancet Lond Engl. 2018;392:637\u201349.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Efficacy%20and%20safety%20of%20semaglutide%20compared%20with%20liraglutide%20and%20placebo%20for%20weight%20loss%20in%20patients%20with%20obesity%3A%20a%20randomised%2C%20double-blind%2C%20placebo%20and%20active%20controlled%2C%20dose-ranging%2C%20phase%202%20trial&amp;journal=Lancet%20Lond%20Engl&amp;volume=392&amp;pages=637-649&amp;publication_year=2018&amp;author=O%E2%80%99Neil%2CPM&amp;author=Birkenfeld%2CAL&amp;author=McGowan%2CB&amp;author=Mosenzon%2CO&amp;author=Pedersen%2CSD&amp;author=Wharton%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Wang A, Speakman JR. Potential downsides of calorie restriction. Nat Rev Endocrinol. 2025;21:427\u201340.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Potential%20downsides%20of%20calorie%20restriction&amp;journal=Nat%20Rev%20Endocrinol&amp;volume=21&amp;pages=427-440&amp;publication_year=2025&amp;author=Wang%2CA&amp;author=Speakman%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Neeland IJ, McGuire DK, Chilton R, Crowe S, Lund SS, Woerle HJ, et al. Empagliflozin reduces body weight and indices of adipose distribution in patients with type 2 diabetes mellitus. Diab Vasc Dis Res. 2016;13:119\u201326.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXmtVKjs70%3D\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Empagliflozin%20reduces%20body%20weight%20and%20indices%20of%20adipose%20distribution%20in%20patients%20with%20type%202%20diabetes%20mellitus&amp;journal=Diab%20Vasc%20Dis%20Res&amp;volume=13&amp;pages=119-126&amp;publication_year=2016&amp;author=Neeland%2CIJ&amp;author=McGuire%2CDK&amp;author=Chilton%2CR&amp;author=Crowe%2CS&amp;author=Lund%2CSS&amp;author=Woerle%2CHJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Butler J, Shah SJ, Petrie MC, Borlaug BA, Abildstr\u00f8m SZ, Davies MJ, et al. Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials. Lancet Lond Engl. 2024;403:1635\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXpvFGmsbY%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Semaglutide%20versus%20placebo%20in%20people%20with%20obesity-related%20heart%20failure%20with%20preserved%20ejection%20fraction%3A%20a%20pooled%20analysis%20of%20the%20STEP-HFpEF%20and%20STEP-HFpEF%20DM%20randomised%20trials&amp;journal=Lancet%20Lond%20Engl&amp;volume=403&amp;pages=1635-1648&amp;publication_year=2024&amp;author=Butler%2CJ&amp;author=Shah%2CSJ&amp;author=Petrie%2CMC&amp;author=Borlaug%2CBA&amp;author=Abildstr%C3%B8m%2CSZ&amp;author=Davies%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Stockner A, Degli Innocenti M, Verma D, T Schmid S, Fuerlinger A, Varghese A, et al. Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF. Circ Res. 2025;136:1519\u201322.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013;9:785\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhsFOiurbI\" aria-label=\"CAS reference 13\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Development%20of%20small-molecule%20inhibitors%20targeting%20adipose%20triglyceride%20lipase&amp;journal=Nat%20Chem%20Biol&amp;volume=9&amp;pages=785-787&amp;publication_year=2013&amp;author=Mayer%2CN&amp;author=Schweiger%2CM&amp;author=Romauch%2CM&amp;author=Grabner%2CGF&amp;author=Eichmann%2CTO&amp;author=Fuchs%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Takahara S, Ferdaoussi M, Srnic N, Maayah ZH, Soni S, Migglautsch AK, et al. Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation. Am J Physiol Heart Circ Physiol. 2021;320:H432\u201346.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXjvVymu7c%3D\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20ATGL%20in%20adipose%20tissue%20ameliorates%20isoproterenol-induced%20cardiac%20remodeling%20by%20reducing%20adipose%20tissue%20inflammation&amp;journal=Am%20J%20Physiol%20Heart%20Circ%20Physiol&amp;volume=320&amp;pages=H432-H446&amp;publication_year=2021&amp;author=Takahara%2CS&amp;author=Ferdaoussi%2CM&amp;author=Srnic%2CN&amp;author=Maayah%2CZH&amp;author=Soni%2CS&amp;author=Migglautsch%2CAK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Lettieri Barbato D, Tatulli G, Aquilano K, Ciriolo MR. Inhibition of age-related cytokines production by ATGL: a mechanism linked to the anti-inflammatory effect of resveratrol. Mediators Inflamm. 2014;2014: 917698.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20age-related%20cytokines%20production%20by%20ATGL%3A%20a%20mechanism%20linked%20to%20the%20anti-inflammatory%20effect%20of%20resveratrol&amp;journal=Mediators%20Inflamm&amp;volume=2014&amp;publication_year=2014&amp;author=Lettieri%20Barbato%2CD&amp;author=Tatulli%2CG&amp;author=Aquilano%2CK&amp;author=Ciriolo%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Dixon ED, Claudel T, Nardo AD, Riva A, Fuchs CD, Mlitz V, et al. Inhibition of ATGL alleviates MASH via impaired PPAR\u03b1 signalling that favours hydrophilic bile acid composition in mice. J Hepatol. 2025;82:658\u201375.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXislOhsbnI\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20ATGL%20alleviates%20MASH%20via%20impaired%20PPAR%CE%B1%20signalling%20that%20favours%20hydrophilic%20bile%20acid%20composition%20in%20mice&amp;journal=J%20Hepatol&amp;volume=82&amp;pages=658-675&amp;publication_year=2025&amp;author=Dixon%2CED&amp;author=Claudel%2CT&amp;author=Nardo%2CAD&amp;author=Riva%2CA&amp;author=Fuchs%2CCD&amp;author=Mlitz%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Packer M. Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium. J Am Coll Cardiol. 2018;71:2360\u201372.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXpsFCns7s%3D\" aria-label=\"CAS reference 17\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epicardial%20adipose%20tissue%20may%20mediate%20deleterious%20effects%20of%20obesity%20and%20inflammation%20on%20the%20myocardium&amp;journal=J%20Am%20Coll%20Cardiol&amp;volume=71&amp;pages=2360-2372&amp;publication_year=2018&amp;author=Packer%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Schweiger M, Romauch M, Schreiber R, Grabner GF, H\u00fctter S, Kotzbeck P, et al. Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. Nat Commun. 2017;8:14859.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXkvFWlt78%3D\" aria-label=\"CAS reference 18\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pharmacological%20inhibition%20of%20adipose%20triglyceride%20lipase%20corrects%20high-fat%20diet-induced%20insulin%20resistance%20and%20hepatosteatosis%20in%20mice&amp;journal=Nat%20Commun&amp;volume=8&amp;publication_year=2017&amp;author=Schweiger%2CM&amp;author=Romauch%2CM&amp;author=Schreiber%2CR&amp;author=Grabner%2CGF&amp;author=H%C3%BCtter%2CS&amp;author=Kotzbeck%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Abdellatif M, Sedej S. Cardiovascular benefits of intermittent fasting. Cardiovasc Res. 2020;116:e36\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXht1Kkt7rE\" aria-label=\"CAS reference 19\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cardiovascular%20benefits%20of%20intermittent%20fasting&amp;journal=Cardiovasc%20Res&amp;volume=116&amp;pages=e36-e38&amp;publication_year=2020&amp;author=Abdellatif%2CM&amp;author=Sedej%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, et al. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022;603:926\u201333.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XntlGgtbw%3D\" aria-label=\"CAS reference 20\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20single-cell%20atlas%20of%20human%20and%20mouse%20white%20adipose%20tissue&amp;journal=Nature&amp;volume=603&amp;pages=926-933&amp;publication_year=2022&amp;author=Emont%2CMP&amp;author=Jacobs%2CC&amp;author=Essene%2CAL&amp;author=Pant%2CD&amp;author=Tenen%2CD&amp;author=Colleluori%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Olga L, Bobeldijk-Pastorova I, Bas RC, Seidel F, Snowden SG, Furse S, et al. Lipid profiling analyses from mouse models and human infants. STAR Protoc. 2022;3: 101679.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XisVyjs7bK\" aria-label=\"CAS reference 21\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lipid%20profiling%20analyses%20from%20mouse%20models%20and%20human%20infants&amp;journal=STAR%20Protoc&amp;volume=3&amp;publication_year=2022&amp;author=Olga%2CL&amp;author=Bobeldijk-Pastorova%2CI&amp;author=Bas%2CRC&amp;author=Seidel%2CF&amp;author=Snowden%2CSG&amp;author=Furse%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022;144:6237\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xos1Khsbw%3D\" aria-label=\"CAS reference 22\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Small-Molecule%20Inhibitors%20Targeting%20Lipolysis%20in%20Human%20Adipocytes&amp;journal=J%20Am%20Chem%20Soc&amp;volume=144&amp;pages=6237-6250&amp;publication_year=2022&amp;author=Grabner%2CGF&amp;author=Guttenberger%2CN&amp;author=Mayer%2CN&amp;author=Migglautsch-Sulzer%2CAK&amp;author=Lembacher-Fadum%2CC&amp;author=Fawzy%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Sedej S, Abdellatif M. Metabolic therapy for managing heart failure with preserved ejection fraction. J Mol Cell Cardiol. 2022;168:68\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/cardiab.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtVyhurjJ\" aria-label=\"CAS reference 23\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20therapy%20for%20managing%20heart%20failure%20with%20preserved%20ejection%20fraction&amp;journal=J%20Mol%20Cell%20Cardiol&amp;volume=168&amp;pages=68-69&amp;publication_year=2022&amp;author=Sedej%2CS&amp;author=Abdellatif%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Ad\u00e3o R, Vasques-N\u00f3voa F, et al. Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med. 2021;13:eabd7064.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Abdellatif M, Vasques-N\u00f3voa F, Trummer-Herbst V, Durand S, Koser F, Islam M, et al. Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. Eur Heart J. 2025;ehaf062.<\/p>\n","protected":false},"excerpt":{"rendered":"Koskinas KC, Van Craenenbroeck EM, Antoniades C, Bl\u00fcher M, Gorter TM, Hanssen H, et al. Obesity and cardiovascular&hellip;\n","protected":false},"author":2,"featured_media":33460,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[30828,5239,64,63,30829,5240,1835,137,17395,1624,30830,4390],"class_list":{"0":"post-33459","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-adipose-tissue","9":"tag-angiology","10":"tag-au","11":"tag-australia","12":"tag-caloric-restriction","13":"tag-cardiology","14":"tag-diabetes","15":"tag-health","16":"tag-hfpef","17":"tag-inflammation","18":"tag-lipolysis","19":"tag-obesity"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/33459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=33459"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/33459\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/33460"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=33459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=33459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=33459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}