{"id":391613,"date":"2026-01-04T19:03:11","date_gmt":"2026-01-04T19:03:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/391613\/"},"modified":"2026-01-04T19:03:11","modified_gmt":"2026-01-04T19:03:11","slug":"one-injection-might-be-enough-to-fight-breast-cancer-revolutionary-breakthrough","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/391613\/","title":{"rendered":"One injection might be enough to fight breast cancer \u2014 revolutionary breakthrough"},"content":{"rendered":"

An experimental molecule has completely eradicated breast tumors in mice with just one injection \u2014 a stunning result that could reshape how we treat breast cancer. While more research is needed to confirm its safety and effectiveness in humans, the discovery marks a major leap forward.<\/p>\n

Breast cancer remains the second leading cause of cancer-related deaths among women. Roughly 70% of cases are ER\u03b1+ (estrogen receptor alpha\u2013positive), meaning the tumor cells grow in response to estrogen. Current therapies \u2014 such as aromatase inhibitors and drugs like tamoxifen, fulvestrant, and elacestrant \u2014 slow tumor growth<\/a> but rarely eliminate it entirely. They also require years of continuous treatment, often accompanied by heavy side effects that make long-term use difficult.<\/p>\n

Enter ErSO-TFPy, a new molecule that could change everything. In a recent study published in ACS Central Science, researchers demonstrated that a single injection of ErSO-TFPy eradicated large tumors in mice within days \u2014 a result scientists call \u201cremarkable.\u201d<\/p>\n

ErSO-TFPy: how it works and why it\u2019s so promising<\/p>\n

ErSO-TFPy belongs to a new class of compounds that specifically target ER\u03b1+ cancer cells. It works by disrupting ionic balance inside the tumor cells, triggering extreme stress and a rapid, necrotic death. In mouse experiments, one intravenous injection caused the complete regression of large tumors \u2014 between 500 and 1,500 mm\u00b3.<\/p>\n

Unlike traditional treatments that merely slow tumor growth, ErSO-TFPy destroys the cancer cells entirely within a few days. Further research has shown that its effect depends on activating the TRPM4 ion channel, which causes a massive influx of ions into the cancer cell \u2014 essentially bursting it. Because this mechanism is specific to ER\u03b1+ cells, healthy tissues remain unaffected, suggesting the drug could significantly limit side effects.<\/p>\n

\"\"<\/p>\n

The studies were conducted on mice. \u00a9 MP-AI, Adobe Stock (AI-generated image)<\/p>\n

A new hope for patients who\u2019ve run out of options<\/p>\n

This potential therapy comes with several game-changing advantages:<\/p>\n

One injection is enough: unlike current treatments requiring years of daily doses.<\/p>\n

Kills, not just slows: where standard anti-estrogen drugs halt growth, ErSO-TFPy rapidly kills cancer cells.<\/p>\n

Lower resistance risk: its powerful and fast action could prevent mutations that lead to treatment resistance.<\/p>\n

Fewer side effects: a one-time therapy means fewer issues with tolerance and adherence.<\/p>\n

Preclinical results are highly encouraging, though clinical trials are still necessary to test the molecule\u2019s safety and effectiveness in humans. If those studies confirm the findings, ErSO-TFPy could become a groundbreaking therapy for thousands of women with advanced or treatment-resistant ER\u03b1+ breast cancer.<\/p>\n

For now, this discovery opens a new frontier in cancer therapy<\/a> \u2014 one where treatments are more targeted, better tolerated, and potentially more effective than anything currently available.<\/p>\n

\"stephanie-le-guillou\"<\/p>\n

St\u00e9phanie Le Guillou<\/p>\n

Health journalist<\/p>\n

With a PhD in Pharmacy and Cancer Biology, this expert has worked in hospitals, the pharmaceutical industry, and a healthcare communication agency.<\/p>\n

Today, she pursues her passion for writing, creating medical content for the general public. She regularly contributes to Futura\u2019s Health section, striving to make medical information more accessible.<\/p>\n","protected":false},"excerpt":{"rendered":"An experimental molecule has completely eradicated breast tumors in mice with just one injection \u2014 a stunning result…\n","protected":false},"author":2,"featured_media":391614,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[64,63,137,500],"class_list":{"0":"post-391613","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-healthcare","8":"tag-au","9":"tag-australia","10":"tag-health","11":"tag-healthcare"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/391613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=391613"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/391613\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/391614"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=391613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=391613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=391613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}