{"id":410625,"date":"2026-01-13T19:14:09","date_gmt":"2026-01-13T19:14:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/410625\/"},"modified":"2026-01-13T19:14:09","modified_gmt":"2026-01-13T19:14:09","slug":"oprah-winfrey-reveals-glp-1-caused-this-side-effect","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/410625\/","title":{"rendered":"Oprah Winfrey Reveals GLP-1 Caused This Side Effect"},"content":{"rendered":"

Oprah Winfrey says she had one big main side effect from taking a GLP-1 weight-loss drug.<\/p>\n

The most common problems for patients taking blockbuster anti-obesity medications like Wegovy and Zepbound are gastrointestinal issues including nausea, diarrhea and constipation.<\/p>\n

“I never had nausea or diarrhea, but I did have the third one,” Winfrey told TODAY\u2019s Jenna Bush Hager and Sheinelle Jones during a live interview on Tuesday, Jan. 13.<\/p>\n

“I finally figured out, for me, what the right combination of magnesium and water is. I have to drink a lot of water… I have to have a gallon of water a day.”<\/p>\n

Winfrey added that she has to drink all of that water before 4 p.m.; otherwise, she’s up all night.<\/p>\n

Water helps soften stool and move food through the intestines, easing constipation<\/a>. <\/p>\n

Magnesium citrate helps by causing stool to retain water, softening it, making it easier to pass and increasing the frequency of bowel movements, according to the National Library of Medicine<\/a>.<\/p>\n

Winfrey writes about finally finding weight-loss success with a GLP-1 drug in her new book, “Enough: Your Health, Your Weight, and What It\u2019s Like to Be Free.”<\/p>\n

“Oprah’s kidneys are very, very happy,” said Dr. Ania Jastreboff, her co-author and an endocrinologist and associate professor at the Yale School of Medicine. <\/p>\n

Every medicine for any disease has side effects, and there\u2019s always a risk-to-benefit ratio to consider, Jastreboff added.<\/p>\n

Hydration is also one of the best ways to lessen nausea, a side effect that can frustrate GLP-1 users, as is increasing the dose of the medication very slowly, she said. <\/p>\n

“So start low, go slow. If you’re feeling nauseated, then don’t increase the dose,” Jastreboff advised.<\/p>\n

“And there’s other things: Not eating past the point of fullness, making sure you’re monitoring which foods could make you (feel) worse. All of these different things can lower the side effects.”<\/p>\n","protected":false},"excerpt":{"rendered":"Oprah Winfrey says she had one big main side effect from taking a GLP-1 weight-loss drug. The most…\n","protected":false},"author":2,"featured_media":410626,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29],"tags":[64,63,134,427],"class_list":{"0":"post-410625","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-tv","8":"tag-au","9":"tag-australia","10":"tag-entertainment","11":"tag-tv"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/410625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=410625"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/410625\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/410626"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=410625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=410625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=410625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}