For their discovery of genomic imprinting, developmental biologists Davor Solter and Azim Surani will receive the 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, endowed with \u20ac120,000, on March 14 at Frankfurt\u2019s Paulskirche. They discovered that we inherit some genes only in one active copy, determined by a molecular mark specifying maternal or paternal origin \u2013 thereby laying the foundation for the field of epigenetics. The Early Career Award will be presented to neurologist Varun Venkataramani, who demonstrated that malignant brain tumors accelerate growth by tapping into nerve currents, helping establish the field of cancer neuroscience.<\/p>\n
A long-standing principle of genetics held that every body cell contains two active copies of each gene. In 1984,Davor Solter\u00a0and\u00a0Azim Surani\u00a0overturned this basic rule. They demonstrated that some genes are only inherited in one active copy \u2013 either the maternal or paternal copy is permanently deactivated. Working independently yet in parallel, they used a cell nucleus transplantation technique developed by Solter to show that mouse embryos containing only maternal or only paternal genetic material were not viable \u2013 contradicting established doctrine. \u00a0Their findings revealed that mammals, including humans, require the full genetic contribution of both parents. This sets them apart from species capable of reproducing through parthenogenesis from unfertilized eggs. The underlying mechanism: of the two gene copies inherited from mother and father, some are selectively switched off by epigenetic imprints \u2013 small molecular tags attached to DNA. Surani termed this phenomenon genomic imprinting.<\/p>\n
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This discovery was a turning point in modern genetics. It showed that our phenotype is not determined by genotype alone, but also shaped by epigenetic marks.\u201d<\/p>\n
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Prof. Thomas Boehm, Chairman of the Scientific Council<\/p>\n
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Genomic imprinting is essential for healthy embryonic development, as it balances the competition for limited resources between mother and fetus. Its medical relevance extends far beyond embryology: We know that around one percent of human genes are imprinted, many of them embedded in signaling pathways that influence health and disease in adulthood. The discovery of genomic imprinting gave rise to modern epigenetics<\/a> \u2013 the study of molecular mechanisms that regulate gene expression without altering DNA sequence. Epigenetic changes play a key role in cancer, for example \u2013 an insight that has already led to the development of targeted therapies.<\/p>\n Brain tumors do not arise from nerve cells, which \u2013 with few exceptions \u2013 no longer divide. Most are gliomas, originating from glial cells<\/a> that normally support and nourish nerve cells.\u00a0Varun Venkataramani\u00a0discovered that gliomas form synapses with neurons, allowing them to tap into electrical signals that drive tumor growth and spread. Over the past decade, he and his mentors have validated and deepened this unexpected finding, helping establish the field of cancer neuroscience. The work has also opened a new therapeutic avenue: disrupting the tumor\u2019s access to neural signaling to halt its growth \u2013 an approach currently being tested in a Phase II clinical trial.<\/p>\n \u00a0<\/p>\n Source:<\/p>\n