Announcing a new article publication in BIO Integration. The tumor vasculature, characterized by pathological angiogenesis and structural abnormalities, drives the progression of solid tumors by inducing hypoxia-acidosis microenvironments and therapeutic resistance. Targeting the tumor vasculature has emerged as a critical therapeutic strategy.<\/p>\n
Although conventional approaches such as anti-angiogenic drugs, vascular disrupting agents, and embolization have shown efficacy<\/a>, their single-target focus hinders addressing tumor heterogeneity and evolving stage-specific needs. For example, rapid vascular disruption is effective for debulking advanced tumors, whereas vascular normalization enhances early- to mid-stage therapy by improving postoperative chemo-radiotherapy outcomes. Unlike single-mechanism interventions, ultrasound modulates acoustic parameters to achieve diverse effects including angiogenesis suppression, vessel disruption, and vasodilation, thus addressing multi-stage vascular needs. Ultrasound-based monitoring systems provide precise, dynamic vascular assessments to guide intervention strategies.<\/p>\n Compared with traditional static imaging ultrasound offers real-time angiogenesis visualization and therapeutic response evaluation, thus enabling treatment optimization. This review synthesizes recent advances in ultrasound-based vascular targeting, emphasizing its dual role in spatiotemporally adaptive therapy and angiogenesis monitoring. We critically examine clinical translation challenges and future directions, highlighting how ultrasound-driven strategies, by bridging mechanistic precision with clinical scalability, might enable personalized, multi-effect therapeutic paradigms in oncology.<\/p>\n Source:<\/p>\n Journal reference:<\/p>\n Lingling Lei, Huai Yang and Meng Du et al. Harnessing Ultrasound for Tumor Vascular Targeting: From Mechanistic Insights to Clinical Monitoring and Therapeutic Applications.\u00a0BIOI.\u00a02026.\u00a0DOI: 10.15212\/bioi-2025-0117.\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/bioi-2025-0117<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Announcing a new article publication in BIO Integration. The tumor vasculature, characterized by pathological angiogenesis and structural abnormalities,…\n","protected":false},"author":2,"featured_media":113931,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[285086,64,63,1730,137,51857,1366,39080,4393,14110,40847,61693],"class_list":{"0":"post-581921","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-angiogenesis","9":"tag-au","10":"tag-australia","11":"tag-drugs","12":"tag-health","13":"tag-hypoxia","14":"tag-language","15":"tag-therapy","16":"tag-tumor","17":"tag-ultrasound","18":"tag-vascular","19":"tag-vasculature"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/581921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=581921"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/581921\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/113931"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=581921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=581921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=581921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}