Prof Loos said the genetic effect, while modest, “is similar to other factors – and not trivial”.<\/p>\n
However she said the findings need to be reproduced in other studies and, to date, that has not happened.<\/p>\n
For Dr Marie Spreckley, from the University of Cambridge, “genetics is only one part of a much more complex picture”. <\/p>\n
She said the main drivers of outcomes are “behavioural, clinical, and treatment-related factors”. So how much daily exercise and healthy eating people do alongside taking the medication, as well as support and advice offered, plus other underlying health issues.<\/p>\n
But there are other factors at play too.<\/p>\n
Women are more than twice as likely to lose 15% of their body weight on Mounjaro than men, previous research suggests.<\/p>\n
Being younger, white or Asian are also thought to be linked to more weight loss – although the reasons are not fully understood.<\/p>\n
And the type of medication used, the dose and how long it is taken for have all been linked with greater weight loss.<\/p>\n
In the long term, taking genetic and other information together could help guide the choice of which weight-loss drug to use, based on the potential benefits – something called “precision medicine”.<\/p>\n
But we are not there yet, said Professor Naveed Sattar, metabolic health expert from the University of Glasgow.<\/p>\n
“Overall, these findings are scientifically interesting, but they are a long way from changing clinical practice,” he said.<\/p>\n
“What we really need now is more robust trial data to better define the balance of benefits and harms with these and many other emerging newer therapies.”<\/p>\n","protected":false},"excerpt":{"rendered":"Prof Loos said the genetic effect, while modest, “is similar to other factors – and not trivial”. However…\n","protected":false},"author":2,"featured_media":593759,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[64,63,137,490],"class_list":{"0":"post-593758","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medication","8":"tag-au","9":"tag-australia","10":"tag-health","11":"tag-medication"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/593758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=593758"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/593758\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/593759"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=593758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=593758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=593758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}