Genome Medicine<\/a>, the study examined why 2 specific PAM gene variants increase the risk of type 2 diabetes and how they influence treatment response.<\/p>\nThe study is said to build on previous studies, which have shown the PAM\u00a0gene increases the risk of type 2 diabetes by reducing the amount of insulin released from the pancreas and altering the structure of hormones, including the GLP-1 hormone which regulates blood sugar.<\/p>\n
\u201cIn recent years there have been major improvements in the treatment of diabetes and obesity, driven by the widespread use of GLP-1 based medications, like Ozempic,\u201d says lead author Dr Mahesh Umapathysivam from Adelaide University\u2019s Centre of Research Excellence: Translating Nutritional Science to Good Health.<\/p>\n
\u201cHowever, not all patients respond well to these treatments.<\/p>\n
\u201cUnderstanding why and how to predict who will respond well or poorly will allow us to have the best chance to get the right medication to the right patient.\u201d<\/p>\n
In this most recent study, researchers demonstrated that genetic variants in the PAM gene made the enzyme less effective, elevated natural GLP-1 levels, and blocked the hormone\u2019s beneficial effects\u00a0on blood sugar levels.<\/p>\n
\u201cThis suggests that people with PAM variants had some resistance to GLP-1,\u201d says Adelaide University in a recent statement.<\/p>\n
The researchers then examined how this affected the body\u2019s response to GLP-1 medications.<\/p>\n
Adelaide University says, \u201cIn people with the PAM genetic variants, the glucose-lowering properties of the medications were reduced by up to 44% at 6 months of use.<\/p>\n
\u201cOnly 11% of carriers of the more damaging PAM\u00a0variant were able to achieve recommended glucose levels while on this type of medication, compared to approximately 25% of people who didn\u2019t have the gene variants.\u201d<\/p>\n
\u201cOur study is one of the first to provide in-depth, clinical evidence to show how people who carry specific gene variants are at greater risk of developing diabetes and also have a reduced response to GLP-1 receptor medication,\u201d says Dr Umapathysivam.<\/p>\n
\u201cA likely development of this research is that, as other genetic variants that predict response to diabetes medication are found, we can combine this information to determine which diabetes medication will have the greatest chance of improving blood sugar levels and diabetes care for a patient.<\/p>\n
\u201cOur hope is that this research will serve as a blueprint for future studies looking at genetic variants, eventually leading to the development of a genetic testing panel to identify the best medication for the patient, maximising the chance of good diabetes care and minimising the risk of adverse outcomes.\u201d<\/p>\n
Adelaide University says the results highlight the \u201cneed for more personalised approaches to prescribing these widely used medications, which are also used for weight loss\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"A new international study has raised new questions about how effectively some patients respond to GLP-1 medications, with…\n","protected":false},"author":2,"featured_media":665031,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[67529,64,63,1835,114693,9636,65463,137,7716,321185,337,51932,321186],"class_list":["post-665030","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-adelaide-university","tag-au","tag-australia","tag-diabetes","tag-eth-zurich","tag-glp-1","tag-glp-1-medications","tag-health","tag-ozempic","tag-pam-gene","tag-research","tag-stanford-university","tag-the-university-of-oxford"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/665030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=665030"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/665030\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/665031"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=665030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=665030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=665030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}