Population surveys have found a consistently high prevalence of sleep difficulties across Asia. For instance, 47% of the general population in Taiwan, 39% in Hong Kong, 26 to 31% in Japan, and 28% in Singapore reported poor sleep quality. <\/p>\n
In a recently published randomized, double-blind, placebo-controlled trial<\/a>, hydrolyzed chicken extract (ProBeptigen<\/a>) was shown to improve short-term, long-term, and working memory in middle-aged adults. <\/p>\n A proof-of-concept secondary analysis of data from this trial was conducted in Taiwan to examine whether the sleep quality of the participants improved upon a four-week consumption of ProBeptigen. <\/p>\n Data from 52 healthy subjects aged between 35 and 65 years old with poor baseline sleep quality\u2014Pittsburgh Sleep Quality Index (PSQI) score of greater than 5\u2014 were analyzed in the current study funded by Suntory Beverage & Food Asia. <\/p>\n The participants were randomly assigned to receive either 670mg of ProBeptigen or a placebo daily. <\/p>\n Following four\u202fweeks of intervention, changes in PSQI global scores did not significantly differ between the two groups. However, the improvement in the subjective sleep quality component score was significantly greater in the ProBeptigen group compared to the placebo group (p\u202f=\u202f0.006). <\/p>\n Additionally, participants who consumed ProBeptigen exhibited a numerically greater improvement in daytime function than those who took placebo, although this difference did not reach statistical significance (p\u202f=\u202f0.064).<\/p>\n While other PSQI domains did not show statistically significant differences, potentially due to the limited sample size, the good safety profile and the improvement of memory reported in the first study indicate that ProBeptigen could be considered as a complementary approach within a multifaceted sleep management strategy. <\/p>\n \u201cThis study suggests that hydrolyzed chicken extract may improve perceived sleep quality, as reflected in PSQI component scores, among healthy adults with poor baseline sleep,\u201d the researchers wrote in Frontiers in Nutrition. <\/p>\n \u201cAlthough no significant between-group differences emerged for PSQI global scores, improvements in specific components are encouraging and support further evaluation in larger, adequately powered trials. ProBeptigen may serve as a supportive nutritional supplement within a broader, multi-pronged strategy for managing sleep health.\u201d <\/p>\n Mechanisms to be elucidated<\/p>\n The findings in this secondary analysis align with previous data on protein hydrolysates. <\/p>\n In a trial<\/a> with Japanese participants suffering from insomnia, bovine alpha-S1 casein tryptic hydrolysate raised PSQI global score and subjective sleep quality component score after two\u202fweeks, and sleep latency and daytime function after four\u202fweeks. <\/p>\n Similarly, a four-week study<\/a> in Korean participants showed improvements in PSQI global score, and daytime functioning measured by the Epworth Sleepiness Scale. <\/p>\n