{"id":79920,"date":"2025-08-19T12:42:08","date_gmt":"2025-08-19T12:42:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/79920\/"},"modified":"2025-08-19T12:42:08","modified_gmt":"2025-08-19T12:42:08","slug":"research-shows-synergistic-effects-of-tunicamycin-and-%ce%b2-lactam-antibiotics-against-gram-positive-bacteria","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/79920\/","title":{"rendered":"Research shows synergistic effects of tunicamycin and \u03b2-lactam antibiotics against gram-positive bacteria"},"content":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. The prevalence of antimicrobial resistance is increasing among gram-positive bacteria, particularly the resistance of methicillin-resistant Staphylococcus aureus (MRSA) to \u03b2-lactam antibiotics.<\/p>\n<p>In this research, checkerboard minimum inhibitory concentration (MIC) assays, time-killing assays, enzyme inhibition assays, hemolysis tests, and cytotoxicity analyses were performed to confirm the synergistic effects of tunicamycin (TUN) in combination with \u03b2-lactam antibiotics at levels without potential cytotoxicity.<\/p>\n<p>TUN at \u2264 1 \u03bcg\/mL decreased the MICs of cephalosporins or penicillins against MRSA strain USA300, which became sensitive. TUN showed synergistic effects with cefuroxime sodium (FIC index \u2264 0.19) against tested gram-positive bacterial strains of both human clinical and animal origin. Time-killing assays indicated that the combination treatment eliminated MRSA 3-9 h after inoculation. Furthermore, the better synergy of specific \u03b2-lactam antibiotics at potentially cytotoxicity-free concentrations in combination with TUN against \u03b2-lactam-resistant gram-positive microorganisms was confirmed.<br \/>&#13;<br \/>\nThis study provides an experimental basis for combination treatment with TUN and \u03b2-lactam antibiotics with specific chemical structures for the clinical treatment of gram-positive bacterial infections.<\/p>\n<p>Source:<\/p>\n<p>Journal reference:<\/p>\n<p>Bai, X., et al. (2025). Tunicamycin and \u03b2-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria.\u00a0Zoonoses. <a href=\"https:\/\/doi.org\/10.15212\/zoonoses-2025-0024\" rel=\"noopener nofollow\" target=\"_blank\">doi.org\/10.15212\/zoonoses-2025-0024<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Announcing a new article publication for Zoonoses journal. The prevalence of antimicrobial resistance is increasing among gram-positive bacteria,&hellip;\n","protected":false},"author":2,"featured_media":64144,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[51316,64,63,1592,6635,60854,137,337,60855],"class_list":["post-79920","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-antimicrobial-resistance","tag-au","tag-australia","tag-bacteria","tag-bacterial","tag-cytotoxicity","tag-health","tag-research","tag-staphylococcus-aureus"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/79920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=79920"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/79920\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/64144"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=79920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=79920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=79920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}