{"id":880962,"date":"2026-09-05T13:34:09","date_gmt":"2026-09-05T13:34:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/au\/880962\/"},"modified":"2026-09-05T13:34:09","modified_gmt":"2026-09-05T13:34:09","slug":"car-t-therapy-shows-promise-against-aggressive-brain-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/au\/880962\/","title":{"rendered":"CAR-T Therapy Shows Promise Against Aggressive Brain Cancer"},"content":{"rendered":"

Original story from Yale School of Medicine (CT, USA)<\/a><\/p>\n

A CAR-T therapy targeting B7-H3 showed promising results in treating recurrent glioblastoma, with over half of patients experiencing tumor stabilization or reduction.<\/p>\n

A new Phase I clinical trial has found that an emerging immunotherapy is promising for the treatment of recurrent glioblastoma, a highly aggressive and fatal brain cancer.<\/p>\n

Chimeric antigen receptor T (CAR-T) cell therapy is a form of immunotherapy that modifies an individual\u2019s own T cells (a type of immune cell) so that they are better able to recognize and destroy cancer cells. The new clinical trial focuses on a form of CAR-T therapy that trains these immune cells to target a protein known as B7-H3, which is highly prevalent in most glioblastomas.<\/p>\n

To determine the safety of B7-H3-targeting CAR-T cell therapy, a team of researchers tested three doses of the treatment in a small cohort of patients whose cancer was not responsive to standard therapies. They found that participants tolerated the therapy well and identified a recommended dose for future research.<\/p>\n

Furthermore, the researchers observed that in over half of the participants, the tumors stopped growing or reduced in size for as long as three years post-treatment \u2013 including one participant whose cancer has remained, to this day, in complete remission. B7-H3-targeting CAR-T cell therapy could bring new hope to patients living with treatment-resistant recurrent glioblastomas who currently have few, if any, options, the team says.<\/p>\n

\u201cWe are excited about figuring out how to treat currently untreatable cancers,\u201d says\u00a0Lieping Chen, United Technologies Corporation Professor in Cancer Research and professor of immunobiology and of medicine at Yale School of Medicine and one of the study\u2019s co-principal investigators.<\/p>\n

Collaborators on the study included a neurosurgical team at Beijing Tiantan Hospital (China) led by Nan Ji, and a team led by Gangxiong Huang, at Tcelltech<\/a> (Mannheim, Germany), a biotech company preparing clinical-grade CAR-T cells.<\/p>\n

A protein upregulated in cancers<\/p>\n

The standard therapy for glioblastoma is a combination of surgery and chemotherapy. In the majority of cases, however, the cancer returns, often in an even more aggressive and treatment-resistant form. Due to the lack of treatment options, the median life expectancy for patients with recurrent glioblastoma is less than a year.<\/p>\n

Chen\u2019s laboratory first identified back in 2001 that the protein B7-H3 is highly upregulated in cancer cells, especially solid tumors such as colorectal, lung, and breast cancers. It\u2019s still unclear to scientists why this molecule is so prevalent in tumors and not in healthy tissues. But since its discovery, researchers have been exploring it as a target for new cancer therapies. Ongoing trials, for example, are studying the efficacy of B7-H3 as a target for antibody-drug conjugates, a cancer treatment in which antibodies bind to proteins on cancer cells to more directly deliver chemotherapy drugs.<\/p>\n

The majority of glioblastomas also express B7-H3. But brain cancers are especially challenging to treat because many emerging therapies such as antibody-drug conjugates can\u2019t pass through the blood\u2013brain barrier. Thus, these therapies have had minimal success in treating glioblastomas, previous research shows.<\/p>\n

Modifying T cells to target B7-H3<\/p>\n

Clinicians most commonly use CAR-T cell therapy to treat blood cancers. But in the new Phase I trial, Chen\u2019s team designed a form of CAR-T cell therapy that targets B7-H3 and studied its effects in 15 patients with recurrent glioblastoma that had not responded to available therapies.<\/p>\n

First, the scientists biopsied the tumors to make sure they expressed B7-H3. Then, they drew blood from all of the participants and used a process called leukophoresis to enrich their T cells. In order to \u201ceducate\u201d the T cells to target B7-H3, they added a gene into the immune cells that produces a protein that binds to B7-H3. This enabled the modified immune cells, called CAR-T cells, to recognize B7-H3 and attack the cancerous cells after being returned to the patients.<\/p>\n

\u201cOne of the advantages of this kind of therapy is that it\u2019s quite safe because we use the patient\u2019s own material,\u201d says Chen, a member of Yale Cancer Center. \u201cWe do a little engineering on the cells and put them back.\u201d<\/p>\n

The researchers studied the effects of the therapy at three different dose levels. To get around the blood-brain barrier, the team injected the cells directly into the tumor site on the brain through a catheter. Because some clinicians use catheters to more easily and directly administer cancer drugs, some participants already had one placed from previous treatments.<\/p>\n

CAR-T cell therapy shows promising initial efficacy<\/p>\n

The trial found that in most participants, B7-H3-targeting CAR-T cell therapy was associated with manageable side effects such as fever, vomiting, and itchy skin. Three participants experienced more serious side effects including increased intracranial pressure and epilepsy, but these adverse events were manageable with clinical intervention. Because severe side effects were most often associated with the highest dose level, the researchers are recommending the second dose level for this therapy going forward.<\/p>\n

While the primary goal of the trial was to evaluate the safety of the CAR-T cell therapy, the researchers also monitored cancer growth post-treatment. In eight of the participants, the cancer had stabilized or even reduced in size. Notably, one patient experienced complete remission of the cancer.<\/p>\n

\u201cWe\u2019re seeing tumors get smaller in patients who have had no other option,\u201d Chen says. \u201cFor a Phase I trial, it is very encouraging to already be seeing clinical effects.\u201d<\/p>\n

The researchers are now further studying the efficacy of this therapy in a Phase II clinical trial, where they hope to recruit even more patients with recurrent glioblastoma. They are also exploring ways to further engineer CAR-T cells to improve the therapy so that it is more effective in killing cancerous cells and that its effects last longer. They plan to study this second-generation therapy over the next several months.<\/p>\n

\u201cHopefully this will bring even more benefits to patients,\u201d Chen says.<\/p>\n

This article has been republished from the following\u00a0materials<\/a>. Material may have been edited for length and house style. For further information, please contact the cited source. Our press release publishing policy can be accessed\u00a0here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Original story from Yale School of Medicine (CT, USA) A CAR-T therapy targeting B7-H3 showed promising results in…\n","protected":false},"author":2,"featured_media":880963,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[64,63,137],"class_list":["post-880962","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-au","tag-australia","tag-health"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/880962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=880962"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/880962\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/880963"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=880962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=880962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=880962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}