UK Biobank<\/a> and the Copenhagen General Population Study (CGPS), provided data on 313,145 individuals with overweight, defined as a BMI of 25 or above (median age 58, approx. 50% female) who were free of coronary heart disease and diabetes.<\/p>\nDuring the follow-up period of more than ten years (up to 18 years in the CGPS and up to 15 years in the UK Biobank), 23,134 developed coronary heart disease, defined as having a diagnosis, a heart attack, a coronary artery bypass, a percutaneous coronary artery intervention (a procedure to open a narrowed or blocked artery) or cardiovascular death.<\/p>\n
About two-thirds of the participants (204,850) were eligible for GLP1-RAs under the current indication.<\/p>\n
More than 90% of those not eligible had a BMI of 25-26.9 and approximately half of those with a BMI of 25-26.9 (44% in the CGPS and 48% in the UK Biobank) had either high remnant cholesterol, low-grade inflammation or both.<\/p>\n
Analysis of the data showed the participants who weren’t covered by the indication but had high remnant cholesterol, low-grade inflammation or both were just as likely to develop coronary heart disease as those who were eligible for the drugs.<\/p>\n
For example, individuals without a GLP-1 RA indication but elevated remnant cholesterol and low-grade inflammation were 41% (CGPS study) and 47% (UK Biobank) more likely to develop cardiovascular disease than those without an indication and healthy levels of cholesterol and inflammation.<\/p>\n
This compares with an increased risk of heart disease of 41% among those in the CGPS study with an indication and 35% in those in the UK Biobank study with an indication.<\/p>\n
<\/p>\n
We know that GLP-1 RAs can cut cholesterol and inflammation and reduce the risk of heart attacks, strokes and other cardiovascular problems.”<\/p>\n
\n
<\/p>\n
Dr. Karen Hvid, Copenhagen University Hospital<\/p>\n
<\/p>\n
“We found that about half of people with a BMI of 25-26.9 had levels of cholesterol and\/or inflammation that increased their risk of heart problems.<\/p>\n
“They had a similar risk of coronary heart disease as those who were eligible for GLP1-RAs for weight loss \u2013 but, as things stand, they would not be prescribed them.<\/p>\n
“Our study makes the case for extending the indication to this group. Clinical trials are now needed.”<\/p>\n
Source:<\/p>\n
European Association for the Study of Diabetes<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"New research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD)…\n","protected":false},"author":2,"featured_media":908504,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[64,63,1728,7548,4379,1888,147029,1835,1730,56184,137,5232,1296,10148,1624,50664,14943,337,9637,7532,42894,555],"class_list":["post-908503","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-au","tag-australia","tag-blood","tag-blood-pressure","tag-cardiovascular-disease","tag-cholesterol","tag-coronary-heart-disease","tag-diabetes","tag-drugs","tag-glp1","tag-health","tag-heart","tag-heart-disease","tag-high-blood-pressure","tag-inflammation","tag-oct","tag-receptor","tag-research","tag-semaglutide","tag-type-2-diabetes","tag-uk-biobank","tag-weight-loss"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/908503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/comments?post=908503"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/posts\/908503\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media\/908504"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/media?parent=908503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/categories?post=908503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/au\/wp-json\/wp\/v2\/tags?post=908503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}