![\"Patrick](\"https:\/\/www.newsbeep.com\/au\/wp-content\/uploads\/2026\/09\/2026-09-21T022945Z_97437631_MT1USATODAY29878505_RTRMADP_3_NFL-INDIANAPOLIS-COLTS-AT-KANSAS-CITY-CHIE.webp\" "\\"Patrick")
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Danny Medley-Imagn Images <\/p>\n
NFL picks against the spread for Week 4Game of Midweek: Steelers\u00a0(-2.5, 38.5\u00a0o\/u) at Browns<\/p>\n
Thursday 8:15 p.m. ET, Amazon Prime Video<\/p>\n
Aaron Rodgers and Deshaun Watson are coming off strong home performances to help their teams win close games. The Steelers<\/a>‘ defense struggled while the Browns<\/a>‘ defense has been hot. The goal for Pittsburgh is making Cleveland one-dimensional so it can tee off on the pass rush. The Browns have just a few more issues overall around Watson.<\/p>\n Pick: Steelers win 20-17 and cover the spread.<\/p>\n AFC Game of the Week: Chiefs (-4.5, 47.5 o\/u) at Raiders<\/p>\n Sunday 4:25 p.m. ET, CBS<\/p>\n The Chiefs<\/a> are locked in offensively like they haven’t been in a while, with Kenneth Walker III sparking everything and Travis Kelce turning back the clock. Patrick Mahomes has become a confident distributor again. The same is true for Kirk Cousins, also a hot passer early in the season. But the Chiefs have a little more reliable and cohesive defense to get the job done.<\/p>\n Pick: Chiefs win 27-20 and cover the spread.<\/p>\n NFC Game of the Week: Rams (-2.5, 46.5 o\/u) at Eagles<\/p>\n Sunday 1 p.m. ET, Fox<\/p>\n The Rams<\/a> are finding plenty of offense with Kyren Williams, Davante Adams and the tight ends, but they still miss that consistent dominant No. 1, Puka Nacua. No Myles Garrett hurts against the Eagles<\/a>‘ offensive line. Jalen Hurts will create more downfield than Matthew Stafford, and having the obvious athletic advantage also helps.<\/p>\n MORE:\u00a0How a controversial pass interference penalty helped Broncos top Rams<\/a><\/p>\n Pick: Eagles win 27-24.<\/p>\n Lock of the Week: Seahawks (-6.5, 43.5 o\/u) over Chargers<\/p>\n Sunday 4:25 p.m. ET, CBS<\/p>\n Seattle got shocked in Washington with the defense having big breakdowns and the offense making too many mistakes. Los Angeles is a lot more lost offensively with Justin Herbert under Mike McDaniel and has become a nightmarish turnover machine under Jim Harbaugh. The Seahawks<\/a> are bound to refocus well and not get caught off guard again at home.<\/p>\n Pick: Seahawks win 24-14 and cover the spread.<\/p>\n Vincent Carchietta\/Imagn Images via Reuters Connect <\/p>\n Upset of the Week: Cowboys\u00a0(+2.5, 47.5 o\/u) over Texans<\/p>\n Sunday 1 p.m. ET, Fox<\/p>\n The Cowboys<\/a> got some of the offense going in Brazil although coming up short against the Ravens<\/a>. The Texans<\/a>‘ offense cannot run well and doesn’t have much passing pop minus Nico Collins and Jayden Higgins. Dak Prescott is better situated in the Lone Star State than C.J. Stroud with CeeDee Lamb, George Pickens, Jake Ferguson and more locked into him.<\/p>\n Pick: Cowboys win 30-20.<\/p>\n MORE:\u00a0Full NFL power rankings for Week 4<\/a><\/p>\n Colts (-3.5, 47.5 o\/u) vs.\u00a0Commanders<\/p>\n Sunday 9:30 a.m. ET, NFL Network (from London, England)<\/p>\n The Colts should make this game about getting the ball in the hands of running back Jonathan Taylor and tight end Tyler Warren as much as possible to settle Daniel Jones and attack the Commanders<\/a>‘ key weaknesses. The Commanders will stay revved up with Marcus Mariota getting help all over the field to make for a fun morning export.<\/p>\n Pick: Colts win 27-24 but fail to cover the spread.<\/p>\n Patriots at Bills (-6.5, 48.5 o\/u)<\/p>\n Sunday 1 p.m. ET, CBS<\/p>\n The Patriots will try to stay in the game with a heavy dose of Rhamondre Stevenson and TreVeyon Henderson in the running game to take pressure off slumping Drake Maye and also go after the Bills’ defensive Achilles’ heel. Unfortunately, the Bills’ defense is more going after takeaways and will get to Maye a few times while Josh Allen rolls along.<\/p>\n Pick: Bills win 24-20 but fail to cover the spread.<\/p>\n MORE:\u00a0\u00a0Inside Drake Maye’s turnover troubles<\/a><\/p>\n Jets at Bears (-3, 44.5 o\/u)<\/p>\n Sunday 1 p.m. ET, Fox<\/p>\n The Jets are staying competitive with Geno Smith leading the offense but the injuries are piling up at the skill positions before this game. That gives the Bears a break without Caleb Williams on a short week at home. They have enough around backup Case Keenum to outscore New York.<\/p>\n Pick: Bears win 24-20 and cover the spread.<\/p>\n Imagn Images <\/p>\n Jaguars at Bengals (-2.5, 51.5 o\/u)<\/p>\n Sunday 1 p.m. ET, CBS<\/p>\n Joe Burrow and Trevor Lawrence make for a great passing duel between consecutive No. 1 overall picks. Burrow is red-hot and Lawrence is feeling it, too. Both are getting help from the running backs and variety of wide receivers. Jacksonville and Cincinnati also are getting good pop from the defensive fronts. The Bengals escape this back-and-forth thriller at home.<\/p>\n Pick: Bengals win 31-27 and cover the spread.<\/p>\n Cardinals at Giants (-1.5, 43.5\u00a0o\/u)<\/p>\n Sunday 1 p.m. ET, CBS<\/p>\n The Cardinals’ offense has a lot of positives under Mike LaFleur. Jacoby Brissett is back on the same page with several passing weapons, and the backfield role of Jeremiyah Love is getting more effective. Jameis Winston’s turnovers make the difference in a mild road upset.<\/p>\n Pick: Cardinals win 23-20.<\/p>\n Packers\u00a0(-3.5, 39.5\u00a0o\/u) at Buccaneers<\/p>\n Sunday 1 p.m. ET, Fox<\/p>\n The Packers need this game badly after flailing against the Falcons. They get the wounded Bucs, a big break with Baker Mayfield on the shelf. Green Bay will deal with an anemic running back supported by an undrafted rookie QB, Jalon Daniels. Jordan Love will continue to stretch the field well with a little less pressure on him this week.<\/p>\n<\/p>\n
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Dolphins at Vikings (-9.5, 39.5\u00a0o\/u)<\/p>\n