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After popping up on the injury report on Thursday, San Francisco 49ers running back Christian McCaffrey appears to be good to go for Sunday’s Week 1 matchup against the Seattle Seahawks.
According to NFL Network’s Ian Rapoport, “signs are pointing to” McCaffrey playing after he was listed as questionable with a calf issue. The three-time All-Pro was working out on a side field during Friday’s practice and will play barring a setback.
When asked about the level of concern on Friday, head coach Kyle Shanahan was tight-lipped, saying, “Questionable concern.” McCaffrey was a little more optimistic, calling the injury “nothing serious” and adding, “I feel great about where I’m at.”
Last season, McCaffrey limited to only four games last season due to calf, Achilles and PCL injuries. The three-time NFL All-Pro and 2023 Offensive Player of the Year has seen injuries be a common theme throughout his career, having played in seven games or fewer in three of his eight NFL seasons, including in 2024.
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Other notable Week 1 injuries:
The newest Green Bay Packer, Micah Parsons, was listed as questionable, but is expected to play, though he will reportedly be on a play count. Parsons, who was limited this week, finished a steroid treatment on his back and planned to hold off getting an injection.
Atlanta Falcons wide receiver Darnell Mooney is questionable after declaring himself a “game-time decision” with a right shoulder injury. He also missed Week 18 last season with a right shoulder injury.
Isaiah Likely is unlikely to play for the Baltimore Ravens in Sunday night’s matchup against the Buffalo Bills as he deals with a foot fracture suffered early in training camp.
The Miami Dolphins are dealing with a slew of injuries as wide receiver Tyreek Hill (oblique) and running backs De’Von Achane (calf) and Jaylen Wright (knee) showed up on their injury report. Head coach Mike McDaniel said Friday that Hill and Achane are “absolutely” on track to play, Wright, however, has been ruled out.
Here’s the rest of the Week 1 injury report:
CAROLINA PANTHERS
WR Jalen Coker (quad): OUT
CB Damarri Mathis (knee): OUT
LT Ikem Ekwonu (appendectomy): doubtful
JACKSONVILLE JAGUARS
G Wyatt Milum (knee): OUT
CB Montaric Brown (ankle): OUT
OT Cole Van Lanen (shoulder): questionable
NEW YORK GIANTSWASHINGTON COMMANDERSPITTSBURGH STEELERS
DL Derrick Harmon (knee): OUT
QB Skylar Thompson (hamstring): questionable
LB Nick Herbig (hamstring)
NEW YORK JETS
G Alijah Vera-Tucker (triceps): OUT
OL Chukwuma Okorafor (hand): questionable
ARIZONA CARDINALS
G Will Hernandez (knee): OUT
DT Dante Stills (heel): questionable
LB Owen Pappoe (quad): questionable
NEW ORLEANS SAINTS
DE Chase Young (calf): OUT
G Trevor Penning (toe): OUT
S Jordan Howden (oblique): questionable
LAS VEGAS RAIDERSNEW ENGLAND PATRIOTS
CB Christian Gonzalez (hamstring): OUT
LT Will Campbell (ankle): questionable
CB Charles Woods (groin): questionable
MIAMI DOLPHINS
RB Jaylen Wright (knee): OUT
CB Ethan Bonner (hamstring): OUT
TE Darren Waller (hip): OUT
WR D’Wayne Eskridge (concussion): questionable
OL James Daniels (ankle): questionable
INDIANAPOLIS COLTS
RB Tyler Goodson (elbow): questionable
CINCINNATI BENGALSCLEVELAND BROWNSTAMPA BAY BUCCANEERS
WR Chris Godwin (ankle): OUT
LT Tristan Wirfs (knee): OUT
CB Benjamin Morrison (quad): OUT
S Christian Izien (oblique): OUT
DT Vita Vea (foot): questionable
ATLANTA FALCONS
OL Jack Nelson (calf): OUT
S DeMarcco Hellams (hamstring): OUT
WR Darnell Mooney (shoulder): questionable
Christian McCaffrey is dealing with another injury concern as the San Francisco 49ers prepare for Week 1. (Photo by Ezra Shaw/Getty Images)
(Ezra Shaw via Getty Images)SAN FRANCISCO 49ERS
WR Brandon Aiyuk (knee): OUT
RB Jordan James (finger): doubtful
WR Jordan Watkins (ankle): doubtful
RB Christian McCaffrey (calf): questionable
SEATTLE SEAHAWKS
WR Jake Bobo (concussion): OUT
LB Uchenna Nwosu (knee): OUT
WR Dereke Young (hamstring): OUT
TENNESSEE TITANS
RB Tyjae Spears (ankle): OUT
S Kevin Winston Jr. (hamstring): doubtful
CB L’Jarius Sneed (knee): questionable
RB Kalel Mullings (ankle): questionable
DENVER BRONCOS
TE Nate Adkins (ankle): OUT
LB Dre Greenlaw (quad): OUT
DT Malcolm Roach (calf): OUT
HOUSTON TEXANS
RB Joe Mixon (foot/ankle): OUT
WR Braxton Berrios (hamstring): OUT
WR Christian Kirk (hamstring): OUT
G Ed Ingram (abdomen): questionable
LOS ANGELES RAMS
CB Ahkello Witherspoon (knee): questionable
DETROIT LIONS
T Jamarco Jones (ankle): OUT
LB Trevor Nowaske (elbow): OUT
RB Sione Vaki (hamstring): OUT
GREEN BAY PACKERS
WR Christian Watson (knee): OUT
S Zayne Anderson (knee): questionable
CB Nate Hobbs (knee): questionable
DL Micah Parsons (back): questionable
WR Jayden Reed (foot): questionable
DL Barryn Sorell (knee): questionable
WR Dontayvion Wicks (calf): questionable
WR Savion Williams (hamstring): questionable
BALTIMORE RAVENS
TE Isaiah Likely (foot): OUT
FB Patrick Ricard (calf): OUT
BUFFALO BILLS
CB Tre’Davious White (groin): doubtful
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MINNESOTA VIKINGS
RB Zavier Scott (ankle): OUT
DL Elijah Williams (hamstring): OUT
S Harrison Smith (illness): doubtful
T Christian Darrisaw (knee): questionable
CHICAGO BEARS
LB T.J. Edwards (hamstring): doubtful
DB Josh Blackwell (groin): questionable
DB Jaylon Johnson (calf/groin): questionable
RB Roschon Johnson (foot): questionable
NFL injury updates live