The Week 1 NFL schedule rolls on Sunday with 13 more games coming, followed by Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Packers at -1.5 versus the Lions and the Steelers at -3 versus the Jets. The Bills opened as slight favorites, but are now +1 against the Ravens in a Sunday Night Football showdown between AFC contenders. The week concludes with the Vikings (-1.5) visiting the Bears on Monday Night Football. 

A set of exact Week 1 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL props you could target as well. Hitting on an exact NFL score prediction could also result in a huge payday. Before making any Week 1 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight up NFL betting picks (69%) and was profitable for bettors. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen’s Week 1 NFL exact score predictions at SportsLine.

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Top Week 1 NFL picks

After diving into all 16 games from the NFL’s Week 1, Cohen likes the Bills (+1.5, 50.5) to narrowly win a rematch of their AFC Divisional Playoff Game victory over the Ravens in a 26-23 final. “In my opinion, these are the two best teams in the NFL and we’ll see this matchup again on Sunday, January 25th, 2026 in the AFC Championship Game.”

“I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home field advantage ranking, the passionate Bills crowd would easily be in the top-5, if not No. 1 overall. That’s the difference in a game that should be very similar to last year’s playoff contest narrowly won by Buffalo.” With that score prediction, Cohen likes the Bills on the money line (+101), to cover the small spread and the Over to hit in this matchup, even though it is the highest total on the Week 1 NFL odds board. See his other Week 1 football score predictions at SportsLine.

How to make Week 1 NFL score predictions

In addition, Cohen is calling for one game to exceed 60 total points this week, making the Over a must bet. Nailing this result is key to making profitable Week 1 NFL picks. You can only see it at SportsLine.

Who wins every Week 1 NFL game, and which games is a must bet for the over? Visit SportsLine now to get Eric Cohen’s NFL Week 1 score predictions, all from the NFL expert who nailed nearly 70% of his NFL straight-up picks last season, and find out.