The Arizona Cardinals host the Seattle Seahawks on ‘Thursday Night Football’ to open the Week 4 NFL schedule. Kickoff is scheduled for 8:15 p.m. ET at State Farm Stadium. The game features a loaded NFL DFS player pool, with some of the biggest names in the sport like Kyler Murray, Sam Darnold, Marvin Harrison Jr., Jaxon Smith-Njigba, and Trey McBride leading the way. Building successful NFL DFS lineups and NFL DFS stacks will require owners to find the right mix of high-priced players and low-cost values. Who are the top NFL DFS sleepers for TNF? 

Finding undervalued players at a cheap price is still the key to building a winning NFL DFS strategy in Showdown contests — especially with this matchup featuring so many big-name players. Should you target potential values like Trey Benson, Tory Horton, or Cooper Kupp to pair with the bigger-name players for Thursday Night Football DFS lineups? Before making any NFL DFS picks for Cardinals vs. Seahawks on Thursday Night Football on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor. 

Kaylor is a NFL betting and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. 

Now, Kaylor has turned his attention to the Thursday Night Football matchup of Seahawks vs. Cardinals and just locked in his top daily Fantasy football picks. You can only see his Thursday Night Football DFS picks and analysis at SportsLine.

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Top NFL DFS picks, lineups, stacks for Cardinals vs. Seahawks

One of Kaylor’s top DFS picks for Seahawks vs. Cardinals is Seattle quarterback Sam Darnold. The former USC standout had a breakout 2024 season with the Minnesota Vikings: in 17 games as the starter, he completed 361 of 545 passes for 4,319 yards, 35 touchdowns, and 12 interceptions, leading the Vikings to a 14-3 regular season record. That performance earned him his first Pro Bowl selection and a lucrative free-agent contract with the Seahawks.

In 2025, Darnold has thrown for 663 yards with four touchdowns and two interceptions, and his completion percentage sits at 70.3%. He has a solid core of weapons at his disposal, led by Jaxon Smith-Njigba, Cooper Kupp and rookie Tory Horton. See who else to roster right here.

Part of Kaylor’s optimal NFL DFS strategy also includes rostering Cardinals tight end Trey McBride. The former second-round pick out of Colorado State has played in 52 career games, catching 238 passes for 2,418 yards and seven receiving touchdowns. In 2024, McBride had a breakout year, catching 111 passes for 1,146 yards with two receiving touchdowns while adding one rushing score.

Through three weeks of the 2025 season, McBride has recorded 17 receptions for 182 yards and one touchdown, averaging over 10 yards per catch. He leads the Cardinals in targets, receptions and yards in 2025, and has an obvious rapport with Arizona quarterback Kyler Murray. You can see the rest of Kaylor’s NFL DFS picks here.

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How to build NFL DFS lineups and stacks for Seahawks vs. Cardinals

Kaylor is also targeting another undervalued player who could explode for huge numbers on Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and get the rest of Kaylor’s NFL DFS picks, at SportsLine. 

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Seahawks vs. Cardinals on Thursday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from SportsLine’s proven DFS expert who won a single-game millionaire maker tournament, and find out.