The Week 4 NFL schedule begins with the Arizona Cardinals hosting the Seattle Seahawks in an NFC West battle on Thursday Night Football. Both teams are off to 2-1 starts this season in what is currently the most competitive division in the league. Seattle is a 1.5-point favorite in the Week 4 NFL odds, while the over/under for total points scored is 43.5. Sunday’s slate brings matchups like Buccaneers vs. Eagles (-3.5), Chiefs vs. Ravens (-2.5) and Cowboys vs. Packers (-7). The week concludes with a Monday Night Football doubleheader, featuring Jets vs. Dolphins (-2.5) and Bengals vs. Broncos (-7.5).    

Bettors looking for sportsbook promos, betting sites, and where to bet on the NFL for Week 4 can read more below, along with picks for some of the biggest games. 

Sportsbook offers

Here are the top sportsbook promos for new users ahead of the 2025 Week 4 NFL schedule.

The DraftKings promo code, bet365 promo code, and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings offers $200 in bonus bets plus more than $200 off NFL Sunday Ticket for the 2025 NFL season. The FanDuel promo code provides new users $300 in bonus bets if their first bet of $5 or more wins.

Both the Fanatics Sportsbook promo code and BetMGM bonus code provide bonus bets, but only if your first bet loses. Fanatics is offering new users the ability to get $100 in FanCash plus $100 No Sweat Bets in FanCash on every football Game Day until October. However, users in New York are limited to $25 in No Sweat Bets in FanCash. Using the BetMGM bonus code CBSSPORTS gives new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in West Virginia, New Jersey, Pennsylvania or Michigan can get a different promotion and claim $150 in bonus bets if you win your first bet of $10 or more. 

The Caesars Sportsbook promo code is different than the others, providing profit boosts instead of bonus bets. After placing a wager of at least $1, you receive 20 100% profit boost tokens with the code CBS20X.

Betting on Week 4 of the 2025 NFL season

SportsLine’s computer model simulates every NFL game 10,000 times. Since its inception, it has generated a betting profit of well over $7,000 for $100 players on top-rated NFL picks. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Over 44 in Buccaneers vs. Eagles

Tampa Bay’s offense has been consistently putting up points so far this season, scoring 20 or more points in all three of its games. The Buccaneers got past the Jets in a 29-27 final last week, as quarterback Baker Mayfield finished with 233 passing yards and a touchdown. Rookie wide receiver Emeka Egbuka had a season-high 85 receiving yards on six catches, further establishing himself as an elite weapon for Mayfield. Philadelphia’s offense has also scored at least 20 points in every game this year, including 26 in the second half of last week’s win over the Rams. There are offensive stars all over the field in this matchup, so the model has the Over cashing in 55% of simulations. 

Packers -7 at Cowboys

Green Bay got off to a hot start this season with wins over the Lions and Commanders, taking an early lead atop the NFC North standings. The Packers held a 10-0 lead over the Browns entering the fourth quarter last week, but gave up 13 consecutive points to finish the game. Dallas has lost two of its first three games, and it needed overtime to pick up its lone win over the Giants. The Cowboys are coming off a 31-14 loss to the Bears, and the model has Green Bay covering 55% of the time this week.  

Broncos -7.5 vs. Bengals

Cincinnati’s season was turned on its head when quarterback Joe Burrow went down with a toe injury that will sideline him for about three months. The Bengals struggled significantly without their starting quarterback in Week 3, losing to the Vikings by a final score of 48-10. Backup quarterback Jake Browning finished with just 140 passing yards and two interceptions on 27 attempts. Denver will be happy to return home following a pair of close road losses, as it opened the season with a 20-12 win over the Titans. The model views this as a perfect bounce-back opportunity for the Broncos, who cover the spread 55% of the time. 

Responsible gaming

Responsible gaming is extremely important, which is why sportsbooks provide tools such as wager limits to help out their users. National resources are also available for bettors, including The National Council on Problem Gaming, Gamblers Anonymous, and 1-800-GAMBLER.